American lobster (Homarus americanus) immune response to infection with the bumper car parasite (Anophryoides haemophila): A transcriptomic analysis

Clark, Kevin; Acorn, Adam R.; Greenwood, Spencer J.

doi:10.1016/j.fsi.2013.03.041

Cited by 3 publications

(5 citation statements)

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“…This indicates a long period of divergent evolution even if ALF gene cluster 2 is a result of a cluster duplication from ALF cluster 1. The ALF genes, ALF-like1, ALF-like2, and ALF-like3 correspond to ALFHa-2, ALFHa-4, and ALFHa-6, genes that have been previously shown to be up-regulated during bacterial (41), protist (42), and viral (43) pathogen challenges (44).…”

Section: Highlighted Immune Genes In the H Americanus Genomementioning

confidence: 99%

The American lobster genome reveals insights on longevity, neural, and immune adaptations

et al. 2021

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The American lobster, Homarus americanus, is integral to marine ecosystems and supports an important commercial fishery. This iconic species also serves as a valuable model for deciphering neural networks controlling rhythmic motor patterns and olfaction. Here, we report a high-quality draft assembly of the H. americanus genome with 25,284 predicted gene models. Analysis of the neural gene complement revealed extraordinary development of the chemosensory machinery, including a profound diversification of ligand-gated ion channels and secretory molecules. The discovery of a novel class of chimeric receptors coupling pattern recognition and neurotransmitter binding suggests a deep integration between the neural and immune systems. A robust repertoire of genes involved in innate immunity, genome stability, cell survival, chemical defense, and cuticle formation represents a diversity of defense mechanisms essential to thrive in the benthic marine environment. Together, these unique evolutionary adaptations contribute to the longevity and ecological success of this long-lived benthic predator.

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Section: Highlighted Immune Genes In the H Americanus Genomementioning

confidence: 99%

The American lobster genome reveals insights on longevity, neural, and immune adaptations

et al. 2021

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“…The difference be-615 tween the trypsin isoforms highlights an isoform specific reaction 616 to WSSV infection. H. americanus trypsin 1a and 1b expression dur-617 ing infection with the parasitic scuticociliate A. haemophila re-618vealed that trypsin 1a is moderately increased early in the 619 infection while trypsin 1b expression increased over 10-fold in 620 the moribund infected lobsters compared to its time-point control 621(Clark et al, 2013b). Trypsin 1b has also been shown to be up reg-ulated almost 70-fold during H. americanus infection with the Gram-positive bacterium A. viridans while trypsin 1a expression 624 remained unchanged (Clark et al, 2013a).…”

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confidence: 95%

“…Hsp27 has a functional role in 643 apoptosis, and repression of small Hsp expression could lead to in-644 creased viral replication within a cell (Mehlen et al, 1996). Apop-645 tosis is considered an important cellular defence mechanism to 646 WSSV in multiple tissues (Wongprasert et al, 2003 isoforms has previously been shown during Gram-negative and Gram-positive bacterial infections (Beale et al, 2008;Clark et al, 676 2013a), as well as during infection with the parasitic scuticociliate 677 A. haemophila (Clark et al, 2013b). All of these studies noted that 678 there was differential expression of the ALFHa isoforms where A.…”

mentioning

confidence: 96%

Molecular immune response of the American lobster (Homarus americanus) to the White Spot Syndrome Virus

Clark

Greenwood

Acorn

et al. 2013

Journal of Invertebrate Pathology

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“…The majority of RNA-Seq transcriptomic studies on American lobsters have focused on crustacean immune and nervous system function in an evolutionary context with limited consideration of how local ocean conditions influence these processes (Clark et al 2013a;Clark et al 2013b;Clark et al 2013c;Clark et al 2015;McGrath et al 2016). In the past year, however, two published studies Addressing shellfish disease and preventing reduced larval settlement in a warming GoM Amidst the warming in the GoM, new lobster management goals begin to emerge.…”

Section: American Lobster Transcriptomicsmentioning

confidence: 99%

“…Gene expression data at the mRNA level could determine the environmental requirements and critical thresholds for optimal lobster immune function and cuticle development. Clark et al (2013aClark et al ( , 2013bClark et al ( , 2013c) utilized transcriptomics to examine the ability of lobsters to shift their transcriptome to favor an enhanced immune response during infections.…”

Section: Informing the Gom Lobster Fishery Through Transcriptomicsmentioning

confidence: 99%

Shifting Transcriptomes In Changing Waters

Lopez-Anido¹

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My sincerest thank you to, My thesis advisor Dr. Helen Poulos for guiding and reassuring me throughout every step of this project. Her meaningful mentorship and heartfelt advice supported the success of both this thesis and my time at Wesleyan. My mentors Dr. Heather Hamlin and Dr. Amalia Harrington without whom this thesis would not have been possible. I am most thankful for the time I have spent working with and learning from Heather and Amalia. Their never-ending kindness, encouragement, patience, and creativity allowed me to pursue this project and grow as a young scientist.My research and academic advisor Dr. Barry Chernoff for his wisdom and enthusiasm. Through rigorous edits and continuous curiosity, Barry helped me craft the second chapter of this thesis. Thank you for always encouraging me to challenge myself and think in new ways.Alexis Sher, my thesis mentor for all of her edits on very rough drafts. Alexis gifted me positivity throughout the writing process, even during the most frustrating bits.All my friends, especially Julia Cella, Benjy Cahill, Sophie Scobell, and Emma Trapani, for being there during all of my thesis freak outs and for reminding me to breathe. I would not have survived this past year without the love I have received from them. I feel forever grateful for the amount of joy and inspiration my friends have brought me. Thank you for staying by my side throughout it all.Mi familia, mami, papi, Camila, y Virginia por todo su apoyo y amor. Gracias por enseñarme cómo pensar con creatividad y vivir con amor. ¡Los quiero muchísmo! 4 Table of Contents INTRODUCTION .

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American lobster (Homarus americanus) immune response to infection with the bumper car parasite (Anophryoides haemophila): A transcriptomic analysis

Cited by 3 publications

References 0 publications

The American lobster genome reveals insights on longevity, neural, and immune adaptations

The American lobster genome reveals insights on longevity, neural, and immune adaptations

Molecular immune response of the American lobster (Homarus americanus) to the White Spot Syndrome Virus

Shifting Transcriptomes In Changing Waters

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