American Cutaneous Leishmaniasis

Snow, James S.; Satulsky, E. M.; Kean, B. H.

doi:10.1001/archderm.1948.01520130093008

Cited by 22 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first reports of CL in Panama were those described by Darling in 1911 14 , Herrick in 1911 15 , Darling and Connor in 1911 16 and Bates in 1913 17 , who considered the lesions clinically identical to the oriental sore. Fox in 1931 18 summarized the clinical and gross features of the disease as seen in Brazil, but did not stress the histological aspects, which were later summarized by Snow et al in 1948 19 . However, there is only one detailed report from 1952 describing the histopathological changes in skin lesions of patients affected by CL in Panamá 20 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

González

Diaz

Ferreira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama. We analyzed 49 skin biopsy samples from patients with clinical suspicion of CL, by molecular tests (PCR for subgenus Viannia and HSP-70) and by Hematoxylin-Eosin staining. Samples were characterized at the species level by PCR-HSP-70/RFLP. From the 49 samples studied, 46 (94%) were positive by PCR and were characterized as Leishmania (V.) panamensis. Of these, 48% were positive by Hematoxylin-Eosin staining with alterations being observed both, in the epidermis (85%) and in the dermis (100%) of skin biopsies. The inflammatory infiltrate was characterized according to histopathological patterns: lymphohistiocytic (50%), lymphoplasmacytic (61%) and granulomatous (46%) infiltration, being the combination of these patterns frequently found. The predominant histopathological characteristics observed in CL lesions caused by L. (V.) panamensis in Panama were: an intense inflammatory reaction in the dermis with a combination of lymphohistiocytic, lymphoplasmacytic and granulomatous presentation patterns and the presence of ulcers, acanthosis, exocytosis and spongiosis in the epidermis.

show abstract

Section: Introductionmentioning

confidence: 99%

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

González

Diaz

Ferreira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…The case presented would seem to fit into this group. However, Snow et al (1948) suggest that the varying clinical features might be due to other factors, such as differences in climate, racial immunity, or hygienic conditions. Mangabeira-Albernaz (1947) andJaffd (1952) have drawn attention to the development of nasal polypi as a complication of mucocutaneous leishmaniasis.…”

Section: Commen1mentioning

confidence: 99%

“…The lymphatics draining the primary lesion may become thickened and develop nodules along their course. These nodules occasionally break down in the centre, forming fluctuant masses which may eventually ulcerate (Snow et al, 1948). This lymphangitic form bears a striking resemblance to sporotrichosis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

South American Leishmaniasis in London

Emslie¹

1962

BMJ

View full text Add to dashboard Cite

“…The case presented would seem to fit into this group. However, Snow et al (1948) suggest that the varying clinical features might be due to other factors, such as differences in climate, racial immunity, or hygienic conditions. Mangabeira-Albernaz (1947) and Jaffd (1952) have drawn attention to the development of nasal polypi as a complication of mucocutaneous leishmaniasis.…”

Section: Commen1mentioning

confidence: 99%