American College of Radiology guidelines for breast cancer screening.

Abstract

Proof of the benefit of screening mam mography can come only from randomized, controlled trials. Although proof that screen ing mammography can reduce the mortality rate from breast cancer by at least 25% for women 50 years old and older has been available since the mid 1980s [2], several is sues have delayed acceptance of the recom mendation for annual screening for women in their 40s [3]. Controversy arose when retrospective sub group analysis was used to evaluate benefit for women in their 40s separately from benefit for older women. Because the trials were not orig inally designed to study women 40â€"49years old as a cohort, none of the individual trials had sufficient statistical power in the early years offollow-up to permit proofof mortality rate benefit for this subgroup. Mets-analysis was therefore required to accumulate suffi cient numbers to permit crude analysis. Al though meta-analysis of short-term follow-up data showed no statistically significant benefit from screening women in their 40s [4], the most recent meta-analyses, using longer term follow-up, show statistically significant mor tality rate reductions of 18â€"29% for women guidelines replaced the previous recommenda tion for screening mammography every 1â€"2 years for women who are 40â€"49 years old and annual screening for women who are 50 years old and older [11.The new recommendation is justified by the more rapid growth of breast iii mors among younger women. Mammographic screening may also benefit women younger than 40 years old who are at a high risk for breast cancer. This report is a summary of the ACR Task Force on Breast Cancer review.

Advances in computer-aided diagnosis for breast cancer

“…Mammography is currently the only recommended imaging method for breast cancer screening [1,2]. Mammography is especially valuable as an early detection tool because it can identify breast cancer at an early stage, before physical symptoms develop [3].…”

“…Mammography is especially valuable as an early detection tool because it can identify breast cancer at an early stage, before physical symptoms develop [3]. Early detection via mammographic screening and physical examination has demonstrated improved survival from breast cancer in randomized controlled trials [1,2]. However, the high sensitivity of mammography is accomplished at a cost of low specificity.…”

Computer-Aided Interval Change Analysis of Microcalifications on Management for Breast Cancer Detection

“…Mammography is currently the most effective method for early breast cancer detection 1,2 . Radiologists routinely compare mammograms from a current examination with those obtained in previous years, if available, for identifying interval changes, detecting potential abnormalities, and evaluating breast lesions.…”

Efeitos morfológicos, histológicos e moleculares dos moduladores seletivos dos receptores de estrogênios tamoxifeno e raloxifeno na prevenção primária de tumores mamários quimicamente induzidos em ratas

“…Nesse sentido, além da melhora gradativa na tecnologia de exames que possam detectar lesões mais precoces (Kopans, 1995;Feig et al, 1998;Olsen e Gotzsche, 2001;Tabar et al, 2001;Feig, 2002;Lee, 2002;Jackson, 2002; Gøtzsche e Nielsen, 2006) e estímulos para mudanças mais saudáveis nos hábitos e estilos de vida, surge a descoberta de novos medicamentos, com o propósito de se fazer a prevenção primária, entre eles substâncias que tenham ação quimioprotetoras na formação do câncer de mama (Fentiman, 2000;Geller e Vogel, 2005;Bao et al, 2006;Grilli, 2006;Jordan, 2006;Kelloff et al, 2006;Jordan, 2007;Russo et al, 2007).…”