American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations

Gharib, Hossein; Papini, Enrico; Paschke, Ralf; Duick, Daniel S.; Valcavi, Roberto; Hegedűs, László; Vitti, P

doi:10.1007/bf03346587

Cited by 417 publications

(250 citation statements)

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“…The remaining ten nodules showed partial replacement of tumors by regressive changes (case 6,[8][9][10][11][12][13][14][15]17). These lesions had FNA diagnosis of indeterminate in five (FLUS in three, FN in one and suspicious for malignancy in one) and benign in five nodules.…”

Section: Resultsmentioning

confidence: 99%

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Vanishing tumors of thyroid: histological variations after fine needle aspiration

et al. 2016

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Section: Resultsmentioning

confidence: 99%

“…Vanishing tumors of thyroid: histological variations after fine needle aspiration hypo-echogenicity, "taller-than-wide" shape and increased vascularity, are subsequently examined by FNA biopsy to detect the presence and type of cancer cells (6). However, 15-20% of the nodules are deemed indeterminate on cytological results (7).…”

Section: Original Articlementioning

confidence: 99%

Vanishing tumors of thyroid: histological variations after fine needle aspiration

et al. 2016

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“…Since 2010, the AACE-AME-ETA guidelines have recommended thyroid RFA as a possible therapeutic option for the treatment of benign thyroid nodules [2]. Indications for RFA in doi: 10.7243/2053-3640-4-1 thyroid nodules are: symptomatic benign disease (discomfort or pain in the neck, dysphagia, foreign body sensation, coughing or discomfort), aesthetic problems or autonomous functioning nodules [3].…”

Section: Introductionmentioning

confidence: 99%

“…Indications for RFA in doi: 10.7243/2053-3640-4-1 thyroid nodules are: symptomatic benign disease (discomfort or pain in the neck, dysphagia, foreign body sensation, coughing or discomfort), aesthetic problems or autonomous functioning nodules [3]. Thyroid RFA can also be used to treat autonomous nodules if radiometabolic therapy is refused or not practicable [2]. For cystic nodules, mini-invasive therapy is considered in the case of regrowth after percutaneous ethanol ablation [3].…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients treated with radiofrequency ablation for thyroid nodules

Oddo¹,

Felix²,

Repetto³

et al. 2016

Res J Endocrinol Metab

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Background: Many studies have reported mean reductions in nodule volumes and described improvements in the sense of pressure and aesthetic symptoms after radiofrequency ablation. The aim of our study was to document changes in quality of life by means of a 13-scale questionnaire named ThyPRO in a cohort of patients treated with radiofrequency ablation for benign thyroid nodules. Moreover, we assessed the efficacy and safety of the procedure and correlations between efficacy and some features both of the treated nodules and of patients, and evaluated improvements in neck discomfort by means of a visual analogic scale. Methods: 32 patients with benign thyroid nodules were treated with radiofrequency ablation. We evaluated nodule volume, thyroid function and autoimmunity before and after procedures, adverse events during and after procedures, changes in neck discomfort by means of a visual analogic scale and changes in quality of life through the ThyPRO questionnaire at 1, 3, 6 12, 24 and 36 months. We sought correlations between response to radiofrequency ablation and some features of procedures and patients. We divided patients into 2 groups, according to their mean percentage of nodule volume reduction: group 1 (reduction >30%) and group 2 (reduction <30%) to evaluate whether ThyPRO questionnaire scores changed in patients in whom thyroid RFA was more effective. Results: At the last evaluation, nodule volume reduction was 45±9 in group 1, 11±9 in group 2 and 40±25% in the total population. We found a correlation between better volume reduction and greater patient age. Thyroid function and autoimmunity were not modified. Adverse events were few and mild. Visual analogic scale scores improved, though scores on the individual ThyPRO scales did not change, even in group 1. The general subjective impact of thyroid disease on quality of life improved from the 3rd month onwards. Conclusions: In our cohort of patients, quality of life, as evaluated through ThyPRO, did not improve after radiofrequency for benign thyroid nodules. In the literature, changes in quality of life in patients treated with radiofrequency ablation for thyroid nodules have been described in only one paper, while changes in quality of life assessed by means of ThyPRO have never been described.

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“…Sonography allows us to select the nodules for fine-needle aspiration cytology (FNAC) that have suspicious features, regardless of their size (larger or smaller than 1 cm in diameter). Therefore, despite its limited value in differentiating malignant and benign nodules, the sonographic examination is fundamental for the diagnosis, treatment, and follow-up of thyroid nodulesdso much so that it is recommended in the most recent guidelines issued by the AME-ETA-AACE [7]. At present, the most effect method for diagnosing thyroid tumors is FNAC.…”

Section: Introductionmentioning

confidence: 99%

Ultrasoundelastography: Can it provide valid information for differentiation of benign and malignant thyroid nodules?

Raggiunti

Capone²,

Franchi

et al. 2011

Journal of Ultrasound

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KEYWORDSThyroid; Thyroid sonography; Thyroid nodules; Sonoelastography; FNAC.Abstract Ultrasoundelastography (USE) is a new imaging technique that is performed with a normal ultrasound transducer. It provides improved characterization of a tissue or nodule based on the latter's elasticity and stiffness. The aim of the present, prospective study was to assess the validity of USE in characterizing thyroid nodules. USE patterns were analyzed in light of nodule cytology (British Thyroid Association classification) to determine whether these patterns can be used to decide whether or not fine-needle aspiration cytology (FNAC) is indicated. We examined a consecutive series of 617 thyroid nodules in patients referred for the first time to the Endocrinology Unit of Atri Hospital (Atri, [TE]). Patients underwent ultrasonographic and USE examinations of their thyroid nodules, which were then subjected to FNAC. All nodules with Thy 1 cytology were excluded, leaving 567 nodules for analysis. USE findings were classified on the basis of the degree and distribution of elasticity within the lesion: four patterns were identified (1, 2, 3a, 3b, or 4).None of the nodules with Thy 4 cytology (malignant) had USE pattern 1 or 2; patterns 3 and 4 were associated with higher cytologic grades. In conclusion, USE provides additional information on thyroid nodules, which can be used with ultrasound features of the nodules, to decide whether FNAC is indicated. In fact, patterns 1 and 2 do not seem to be associated with Thy 4 cytology.Sommario L'Elastosonografia (ESG) è una nuova tecnica d'immagine che, utilizzando una normale sonda ecografica, consente una migliore caratterizzazione tissutale, fornendo informazioni su elasticità e durezza di un tessuto o di un nodulo.L'obiettivo di questo studio prospettico è quello di valutare l'effettiva validità della ESG nel caratterizzare i noduli tiroidei, associando il pattern elastosonografico al grading citologico e, * Corresponding author.E-mail address: raggibruno@virgilio.it (B. Raggiunti). quindi, valutare se eseguire o meno l'agoaspirazione del nodulo tiroideo, in base al pattern ESG. Sono stati studiati, in serie successiva, 617 noduli tiroidei di pazienti afferiti per la prima volta presso la nostra UO di Endocrinologia del P.O. di Atri (TE), sottoposti ad esame ecografico, elastosonografico e ad agoaspirato con ago sottile (FNAC), per lo studio citologico. Tutti i noduli che al referto citologico presentavano un grado Thy 1 sono stati esclusi dallo studio, pertanto sono stati esaminati 567 noduli. Lo score elastosonografico utilizzato prevede 5 patterns cromatografici (1; 2; 3a; 3b e 4) a seconda della distribuzione di tessuto più o meno elastico all'interno del nodulo. I risultati dell'ESG hanno evidenziato che nessun nodulo con citologico Thy 4 presenta un grado elastosonografico 1 o 2; passando ai patterns elastosonografici 3 e 4 si assiste ad una crescita concomitante del grading citologico. In conclusione l'ESG può essere considerata un ulteriore parametro, in associazione alle caratt...

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American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations

Cited by 417 publications

References 0 publications

Vanishing tumors of thyroid: histological variations after fine needle aspiration

Vanishing tumors of thyroid: histological variations after fine needle aspiration

Quality of life in patients treated with radiofrequency ablation for thyroid nodules

Ultrasoundelastography: Can it provide valid information for differentiation of benign and malignant thyroid nodules?

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