Abstract. Consider a measure-preserving action Γ (X, µ) of a countable group Γ and a measurable cocycle α : X × Γ → Aut(Y ) with countable image, where (X, µ) is a standard Lebesgue space and (Y, ν) is any probability space. We prove that if the Koopman representation associated to the action Γ X is non-amenable, then there does not exist a countable-to-one Borel homomorphism from the orbit equivalence relation of the skew product action Γ α X × Y to the orbit equivalence relation of any modular action (i.e., an inverse limit of actions on countable sets or, equivalently, an action on the boundary of a countably-splitting tree), generalizing previous results of Hjorth and Kechris. As an application, for certain groups, we connect antimodularity to mixing conditions. We also show that any countable, non-amenable, residually finite group induces at least three mutually orbit inequivalent free, measure-preserving, ergodic actions as well as two non-Borel bireducible ones.