Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat ( Rattus norvegicus ), Syrian Hamster ( Mesocricetus auratus ) and Amargosa Vole ( Microtus californicus scirpensis )

Murphy, Brian G; Michel, Adam O.; LaDouceur, E. B.; Bell, Cynthia M; Lin, M. T.; Imai, Denise M.

doi:10.1016/j.jcpa.2017.07.002

Cited by 6 publications

(11 citation statements)

References 19 publications

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“…5 However, ameloblastic carcinoma is exceedingly rare, is reported uncommonly in humans, 5,21 and only a few cases have been reported in horses, dogs, and a rat. 3,4,8,10,11,14,17,22…”

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confidence: 99%

“…Other than horses, ameloblastic carcinoma has been reported in humans, 21 a rat, 17 and 3 dogs, 8,10,11 with some variation in clinical features, histologic findings, and immunohistochemical features among species. In the case reported in a rat, the tumor arose from the left side of the mandible and exhibited locally destructive behavior, with microscopic metastatic disease identified in the ipsilateral submandibular lymph node.…”

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confidence: 99%

“…Histologically, all of the cardinal features of odontogenic epithelium were present, and in addition there were foci of anaplasia and squamous differentiation. 17 Neoplastic cells were immunoreactive against cytokeratin but immunonegative against vimentin. 17 All 3 of the reported canine tumors had locally aggressive behavior without evidence of metastasis, with 2 tumors arising from the mandible 8,10 and 1 tumor arising from the maxilla.…”

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confidence: 99%

“…17 Neoplastic cells were immunoreactive against cytokeratin but immunonegative against vimentin. 17 All 3 of the reported canine tumors had locally aggressive behavior without evidence of metastasis, with 2 tumors arising from the mandible 8,10 and 1 tumor arising from the maxilla. 11 In all 3 cases, the neoplasms were removed surgically with no additional reported treatment, but post-operative prognosis was not reported uniformly; death occurred 2 mo post-operatively in 1 case for unknown reasons, 8 and in another case the dog was doing well 2 y post-operatively.…”

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confidence: 99%

“…5 However, ameloblastic carcinoma is exceedingly rare, is reported uncommonly in humans, 5,21 and only a few cases have been reported in horses, dogs, and a rat. 3,4,8,10,11,14,17,22 In addition to ameloblastoma, a primary differential diagnosis for ameloblastic carcinoma is oral squamous cell carcinoma. These 2 neoplasms can have considerable overlap in gross and histologic features, particularly in poorly differentiated squamous cell carcinomas that may have a spindloid phenotype and scant keratinization.…”

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confidence: 99%

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Ameloblastic carcinoma in horses: case report and literature review

Schreeg

Radkin²,

Haugland

et al. 2022

J VET Diagn Invest

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Ameloblastic carcinoma is a malignant odontogenic neoplasm that has been reported only rarely in veterinary species. A 16-y-old Arabian crossbred mare was presented for evaluation of a hard mass on the body of the mandible, with evidence of osteolysis on radiographs. Incisional biopsies revealed an invasive neoplasm comprised of spindloid epithelial cells with a high mitotic count and partial dual cytokeratin–vimentin immunoreactivity. The horse was euthanized because of rapid tumor progression 3 mo after presentation. Postmortem evaluation revealed partial obliteration of the mandible by a large, firm-to-hard, tan, locally destructive and invasive mass with no gross or histologic evidence of metastasis. Postmortem histology revealed a poorly differentiated epithelial neoplasm with variably prominent features suggestive of odontogenic histogenesis: a plexiform ribbon architecture, infrequent basilar palisading with antibasilar nuclei, rare basilar cytoplasmic clearing, subepithelial matrix hyalinization, and partial dual cytokeratin–vimentin immunoreactivity. Features of malignancy included regions of necrosis, pronounced cellular atypia, a high mitotic count, extensive tissue invasion and local tissue destruction, and extension of neoplastic cells beyond the margins of the mandibular bone. Collectively, these features are most consistent with mandibular ameloblastic carcinoma. Including our case described here, ameloblastic carcinoma has been reported in only 5 horses. The microscopic features reported most consistently are dual cytokeratin–vimentin immunoreactivity, a high mitotic count, and basilar palisading. Ameloblastic carcinoma should be considered as a differential diagnosis for rapidly growing, locally invasive masses arising from the dentate jaw of horses.

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“…5 However, ameloblastic carcinoma is exceedingly rare, is reported uncommonly in humans, 5,21 and only a few cases have been reported in horses, dogs, and a rat. 3,4,8,10,11,14,17,22…”

mentioning

confidence: 99%

mentioning

confidence: 99%