Ameloblastoma modifies tumor microenvironment for enhancing invasiveness by altering collagen alignment

Li, Shujin; Lee, Dong-Joon; Kim, Hyun-Yi; Kim, Junyoung; Jung, Young-Soo; Jung, Han‐Sung

doi:10.1007/s00418-022-02136-7

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Marfan syndrome, which often shows up as aberrant limb development and skeletal growth retardation, can be caused by FBN1 mutations in clinical practice (Asano et al, 2022). COL4A2 genes are upregulated in ECM, collagen remodeling, and tumor microenvironment, and that type I collagen has an important role in ECM-dominated tumor microenvironment for AB bone invasion (Li et al, 2022). Therefore, this study identified four essential AB genes, namely, COL1A2, COL4A2, FBN1, and HPSE, as the crucial ECM components.…”

Section: Discussionmentioning

confidence: 95%

“…González‐Alva et al (2010) showed that HPSE protein promotes tumor growth and osteoclast activity in AB and that it is overexpressed in AB bone tissue and near the invasive front of the tumor nest. It has been recently demonstrated that COL1A1 , COL1A2 , COL4A1 , and COL4A2 genes are upregulated in ECM, collagen remodeling, and tumor microenvironment, and that type I collagen has an important role in ECM‐dominated tumor microenvironment for AB bone invasion (Li et al, 2022). Therefore, this study identified four essential AB genes, namely, COL1A2 , COL4A2 , FBN1 , and HPSE , as the crucial ECM components.…”

Section: Discussionmentioning

confidence: 99%

“…In ECM in vitro research, COL4A2 in PDLSC‐derived ECM enhances the osteogenic development of PDLSCs via the negative regulation of the Wnt/‐linked protein pathway (Wen et al, 2019). The activated FAK/PI3K/AKT pathway is considerably enriched in COL4A2, and ECM can promote the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (MSCs) by activating the FAK/PI3K/AKT pathway (Li et al, 2022; Xu et al, 2022). Fibrillin‐1, a structural protein of ECM, is encoded by the FBN1 gene.…”

Section: Discussionmentioning

confidence: 99%

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Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Zhang,

Wang,

Qian

et al. 2023

Oral Diseases

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ObjectiveTo investigate the effects of key pathogenic genes involved in the development of jaw ameloblastoma (AB) and its associated extracellular matrix (ECM) on osteogenic differentiation in order to provide a theoretical foundation for future research into bone aggressiveness of AB.MethodsThe essential genes were identified by five AB patients for whole‐exome sequencing and the microarray datasets GES38494 and GES132472. Moreover, the expression of key genes and their encoded proteins in AB tissues was explored. In addition, AB‐derived the decellularized ECM (ABdECM) tissues were generated by the decellularization technique. Furthermore, the osteogenic development of periodontal ligament stem cells (PDLSCs) was mimicked by simulating the effects of the AB tumor microenvironment (TME).ResultsThe AB essential genes including COL1A2, COL4A2, FBN1, and HPSE were discovered. Among them, the expression of HPSE was down‐regulated, while that of COL1A2, COL4A2, and FBN1 was noticeably upregulated in AB compared with normal gingival tissues of the jaws. In vitro osteogenic differentiation of PDLSCs was suppressed by the ABdECM.ConclusionsAbnormal ECM proteins encoded by COL4A2, COL1A2, FBN1, and HPSE genes can cause disturbance in the ECM environment of AB and promote bone resorption.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Zhang,

Wang,

Qian

et al. 2023

Oral Diseases

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show abstract

“…A recently published study has reported that the active ECM remodelling by ameloblastoma cells induces tumour invasion. This active remodelling was thought to involve myofibroblasts in ameloblastoma stroma [23] . The matrix remodelling properties of HGFs may be the reason of greater invasion of ameloblastoma cells in our 3D tumouroids.…”

Section: Discussionmentioning

confidence: 99%

Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment

Bakkalci¹,

Zubir²,

Khurram³

et al. 2022

Matrix Biology Plus

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Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma

Chen,

Hong,

Zhao

et al. 2024

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Ameloblastoma modifies tumor microenvironment for enhancing invasiveness by altering collagen alignment

Cited by 5 publications

References 20 publications

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment

Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma

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