Ameloblastoma: Biological profile of 3677 cases

Reichart, Peter A.; Philipsen, H. P.; Sonner, S.

doi:10.1016/0964-1955(94)00037-5

Cited by 638 publications

(751 citation statements)

References 169 publications

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“…Ameloblastoma is an uncommon odontogenic epithelial neoplasm, comprising approximately 1 % of all cysts and tumors of the jaws and from 11 to 59 % of odontogenic tumors [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Ameloblastoma: 25 Year Experience at a Single Institution

Milman

Ying

Pan

et al. 2016

Head and Neck Pathol

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Ameloblastoma is a rare, locally aggressive odontogenic neoplasm, accounting for fewer than 1 % of head and neck tumors. Recent literature suggests that the initial surgical approach and histologic growth patterns are the most important prognostic determinants in ameloblastoma. The aim of this study was to compare the clinical presentation, management, and outcomes of patients with ameloblastoma with data reported in the literature; the study spanned 2 decades at a single institution. The institution's database was searched for all patients with pathologically confirmed ameloblastoma, diagnosed between 1990 and 2015. The data collected included sex, age, clinical and imaging findings, management, histologic pattern, clearance of surgical margins, length of follow-up, time to recurrence, and disease-related mortality. The potential risk factors of recurrence were evaluated using log-rank test, proportional hazard model, and Fisher exact test. Review of the database yielded 54 patients with pathologically confirmed ameloblastoma and follow-up. Recurrence was noted in 13 (24 %) patients. Surgical approach was associated with the risk of recurrence (6.1 % following radical resection vs. 52 % following limited surgery, p = 0.002). There were trends toward higher recurrence rate in the group with pathologically documented positive margins (p = 0.054) and in follicular ameloblastoma (p = 0.35). Transformation into ameloblastic carcinoma was identified in two patients. There was no disease-related mortality. Our study confirms the recent data regarding the importance of radical surgical resection in management of ameloblastoma. Surgical approach appears to be the strongest predictor of tumor clearance.

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“…Ameloblastoma is an uncommon odontogenic epithelial neoplasm, comprising approximately 1 % of all cysts and tumors of the jaws and from 11 to 59 % of odontogenic tumors [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The intraosseous ameloblastomas are collectively termed ''central ameloblastomas'' [3]. Approximately 80 % of central ameloblastomas arise in the mandible, but involvement of the maxilla is rare [1]. Various histologic patterns are recognized in unicystic, solid/multicystic, and peripheral growth variants of ameloblastoma.…”

Section: Introductionmentioning

confidence: 99%

Ameloblastoma: 25 Year Experience at a Single Institution

Milman

Ying

Pan

et al. 2016

Head and Neck Pathol

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“…3 The ameloblastoma can be classified according to predominant histologic pattern as follicular variant which is the predominant variant, plexiform, granular cell, basal cell, desmoplastic, and acanthomatous type. 1 The basal cell ameloblastoma occurs predominantly in the fourth decade, mean age being 57.3 years. 1 In this article, this variant is seen in a 17-year-old patient.…”

Section: Discussionmentioning

confidence: 99%

“…1 The basal cell ameloblastoma occurs predominantly in the fourth decade, mean age being 57.3 years. 1 In this article, this variant is seen in a 17-year-old patient. Most of the published cases report that basal cell variant presented predominantly in males but we present two cases in females.…”

Section: Discussionmentioning

confidence: 99%

“…Several histologic patterns of ameloblastoma are commonly described which include follicular being the most common, plexiform, acanthomatous, granular cell, basal cell, and desmoplastic patterns, although the histopathologic variations do not have significant bearing on the prognosis. The basal cell variant of ameloblastoma accounts for only 2% of the histologic types 1 and majority of the cases have been shown to occur in the mandible. 2 Apart from the primary manifestation as basal cell amelo blastoma, a desmoplastic ameloblastoma can also convert into a more aggressive basal cell ameloblastoma as reported by Makoto Hirota.…”

Section: Introductionmentioning

confidence: 99%

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Basal cell ameloblastoma–review of literature with report of three cases

Giraddi

Anusha

2012

Journal of Oral Biology and Craniofacial Research

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The ameloblastoma is the most common epithelial odontogenic tumor of the jaw with several histologic variants viz. follicular, plexiform, acanthomatous, desmoplastic, and granular cell and basal cell types. The basal cell ameloblastoma is a rare histological variant which tends to demonstrate microscopic features similar to cutaneous basal cell carcinoma and basaloid squamous cell carcinoma. In the current article we report three cases and review the literature of this rare tumor.

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