Ameloblastoma: A rational approach to therapy

Shatkin, Samuel; Hoffmeister, F. S.

doi:10.1016/0030-4220(65)90231-8

Cited by 110 publications

(28 citation statements)

References 7 publications

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“…Sehdev et al ,[15] reported recurrence after the conservative approach (curettage) in more than 90% of 92 ameloblastomas. Shatkin and Hoffmeister[13] reported that 86% of 20 mandibular ameloblastomas recurred after curettage compared with a 14% recurrence rate after en bloc resection. Other authors have reported a series of 84 ameloblastomas in which they found a 52% rate of recurrence in patients treated conservatively and a 25% rate of recurrence in patients with primary tumor treated by the radical approach.…”

Section: Discussionmentioning

confidence: 99%

“…[12–17] Recurrence rates of ameloblastoma are reportedly as high as 15-25% after radical treatment[13–15] and 75-90% after conservative treatment. [13–17] Therefore, wide resection of the jaw in accordance with the treatment of malignant tumors is usually recommended for ameloblastomas. Recent advancements in understanding the biological behaviors of ameloblastoma have led to more rational surgical approaches.…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of ameloblastoma: Conservative or radical approach

Dandriyal¹,

Gupta²,

Pant³

et al. 2011

Natl J Maxillofac Surg

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Aim:The ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits a locally aggressive behavior with a high level of recurrence, being believed theoretically to come from dental lamina remains, the enamel organ in development, epithelial cover of odontogenic cysts or from the cells of the basal layer of the oral mucosa. Especially larger, aggressive lesions require a more radical surgical approach resulting in large jaw defects. This paper discusses our experiences in the management of ameloblastoma tumor in 20 such patients.Materials and Methods:A review of 20 cases of ameloblastoma (6 in the maxillary and 14 in the mandibular region) is presented. The lesions were between 4 and 8 cm in diameter. The methods of treatment consisted of radical surgery (i.e., segmental resection) and conservative treatments (i.e., enucleation with bone curettage). Half the cases were treated conservatively and others surgically.Results:Enucleation with curettage was done in 10 cases, out of which six (60%) showed recurrence, whereas one (10%) case in the surgical group showed recurrence. Relatively higher tendencies of recurrence were observed in the cases treated conservatively. The aesthetic and functional outcomes were satisfying in all patients.Conclusion:According to our opinion, radical surgical resection of ameloblastoma is the treatment of choice, followed by the reconstruction of the defects, allowing good functional and aesthetic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical management of ameloblastoma: Conservative or radical approach

Dandriyal¹,

Gupta²,

Pant³

et al. 2011

Natl J Maxillofac Surg

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“…It is not possible to find recent studies on solid or multicystic ameloblastomas treated by enucleation or curettage, but historical articles suggest a recurrence rate of 60-80% with local treatment only 15,28,50,58 . Recurrence can occur 20 years after initial treatment but usually occurs 2-5 years later 14 .…”

Section: Solid and Multicystic Amelobastomasmentioning

confidence: 98%

Is there a role for enucleation in the management of ameloblastoma?

Pogrel

Montes

2009

International Journal of Oral and Maxillofacial Surgery

151

135

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“…L'étude de coupes histologiques provenant de mandibule réséquée a montré que les cellules améloblastiques peuvent pénétrer l'os jusqu'à 8 mm au-delà des limites cliniques et radiologiques de la lésion. Par conséquent, le traitement conservateur, en l'occurrence l'énucléa-tion, serait responsable d'un taux de récidive important avoisinant les 60-80 % 12,13,14,15 .D'où le recours à la résection large avec 1 cm de marges autour de la lésion. Le nerf alvéolaire inférieur est souvent sacrifié malgré la possibilité de reconstruction moyennant une greffe de nerf si besoin, mais en général, la majorité des patients le tolère sans difficulté.…”

Section: Matériels Et Méthodeunclassified