Ameloblastic Fibrosarcoma of the Mandible

Minard‐Colin, Véronique; Cassagneau, Elizabeth; Supiot, S.; Oberlin, O.; D’hautuille, Cedric; Corradini, Nadège

doi:10.1097/mph.0b013e31821ba989

Cited by 21 publications

(14 citation statements)

References 15 publications

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“…According to cases reported, no significant difference was observed in age and sex distribution between our case and those in the literature [ 12 ]. Although either the maxilla or the mandible may be involved, AFS more frequently occurs in the mandible (79%) than the maxilla (21%) and most that were similar to our case were found in the posterior region of the mandible [ 10 ]. Clinical appearance and symptoms vary among the reported cases, but swelling and pain are the most common clinical findings, as in our patient.…”

Section: Discussionsupporting

confidence: 69%

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Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man

2015

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Patient: Male, 26Final Diagnosis: Ameloblastic fibrosarcomaSymptoms: SwellingMedication: —Clinical Procedure: HemimandibulectomySpecialty: DentistryObjective:Rare diseaseBackground:Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor with a mesenchymal component, showing sarcomatous features and epithelial nests resembling ameloblastic fibroma (AF).Case Report:We report a case of AFS showing epithelial dysplasia arising in a recurrent AF in the left mandible after 3 years in a 26-year-old man, which is regarded as an uncommon histopathologic finding in AFS. We also emphasize the comprehensive clinical, radiographic, and histopathologic evaluation, and immunohistochemical staining of this patient.Conclusions:We conclude that it is important to consider malignancy alternations in the epithelial component of AFS, along with that of the mesenchymal component, to provide a proper diagnosis and treatment of recurrent AF.

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Section: Discussionsupporting

confidence: 69%

“…Ameloblastic fibrosarcoma is usually regarded as a low-to-intermediate-grade malignancy. It has locally aggressive behavior and a high recurrence rate, but rarely metastasizes [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man

2015

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“…Adjuvant radiotherapy has been used with no evidence of recurrence [ 9 ]. Adjuvant chemotherapy has also been used with moderate success [ 17 ], although no specific chemotherapy protocols have been established yet.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

Loya-Solis

González-Colunga

Pérez-Rodríguez

et al. 2015

Case Reports in Pathology

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Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible. Examination revealed an exophytic growth measuring 3 × 3 cm extending from the mandibular left first premolar to the second molar. The patient underwent a left hemimandibular resection. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures with clear margins; one year after the surgical procedure, the patient is clinically and radiologically disease-free.

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“…Previous studies have reported varying demography for AFS, probably because most were small series or case reports. Martinez et al [ 7 ] reported a mean age of 19 years while others reported a mean age of 27.3 years and AFS is reported to be the most common MOT in paediatric age group [ 7 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of 21 cases of malignant odontogenic tumours from two tertiary health centres in Nigeria

Lawal¹,

Soyele²,

Akinyamoju³

2015

Pan Afr Med J

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IntroductionMalignant odontogenic tumours (MOTs) are relatively rare tmours and only few cases have been reported in the sub-Sahara African literature. The aim of this study was to describe the demographic distribution of malignant odontogenic tumours in two tertiary health centres based on the current WHO 2005 classification scheme.MethodsWe reviewed 21 malignant odontogenic tumours out of a total of 374 odontogenic tumours from two Tertiary Health Centres. Information regarding histology, location, patients age and gender for MOTs were analysed using SPSS for Windows (version 20.0; SPSS Inc. Chicago, IL).ResultsTwenty one (5.6%) MOTs out of a total of 374 odontogenic tumours were seen from the two institutions over the study period. The median age for MOTs was 42.0 (±19.0) years (range = 16-66 years). The male: female ratio was 2.5:1 and 85.7% occurred in the mandible. Ameloblastic carcinoma (AC) with 13 (61.9%) cases was the most common MOT. AC had a mean age of 37.5 (±11.9) years. AC had a mandible: maxilla ratio of 5.5:1 with majority (84.6%) occurring in the posterior mandible.ConclusionThis study showed that MOTs are rare lesions. AC was the most common MOT and majority of MOTs occurred in the posterior mandible of male patients. The study helps to better elucidate the demography of MOTs in sub-Sahara Africans.

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Ameloblastic Fibrosarcoma of the Mandible

Cited by 21 publications

References 15 publications

Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man

Epithelial Dysplasia in Ameloblastic Fibrosarcoma Arising from Recurrent Ameloblastic Fibroma in a 26-Year-Old Iranian Man

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

A retrospective study of 21 cases of malignant odontogenic tumours from two tertiary health centres in Nigeria

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