Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region

Gawande, Pushkar; Khande, Kiran; Agrawal, Gaurav; Aditya, Amita

doi:10.1007/s12663-016-0973-8

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…The exclusion criteria were conference abstracts, reviews, and articles with unavailable full text. Eighteen full-length studies were extracted for inclusion, and clinical and radiographic features of AC were recorded (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Literature Review Of Acmentioning

confidence: 99%

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

Xu¹,

Shang²,

Yang³

et al. 2021

Ann Transl Med

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Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumor. The mean age of occurrence for all 141 AC cases analyzed in our systematic review study was 43.59±19.51 years.Males were more affected than females, and the mandible was predominantly affected compared with the maxilla. The main clinical manifestation was a painful or painless swelling with ulceration and radiographic features usually displayed as mixed cystic or solid changes. Surgical resection was the first recommended method of management. Fourteen cases had cervical lymph node spread, 19 had distant metastasis (most commonly in the lung), and 33 had recurrence. We present a rare case of AC involving the maxillary region. Locally extensive surgical resection was carried out. Ablative defects after maxillectomy resulted in the communication of oral cavity and nasal cavity/maxillary antrum and would bring about difficulties in mastication, deglutition, and speech. A submental island flap was applied to close the oronasal and oroantral fistula. The flap and the wounds healed well, with excellent outcomes in terms of appearance, the function of speech, and swallowing on follow up. The submental island flap provides a relatively thin, easy-to-harvest, and well-vascularized tissue, which makes it a reliable option in soft tissue reconstruction of the oral and maxillofacial region.

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Section: Literature Review Of Acmentioning

confidence: 99%

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

Xu¹,

Shang²,

Yang³

et al. 2021

Ann Transl Med

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“…Mitotic figures may attain a count of 2 to 5 per high-power field. 8 Individual cell keratinization and keratin pearl formation may be seen. In our case, mild to moderate pleomorphism, keratin pearl formation and increased mitotic figures were important features in establishing final diagnosis.…”

Section: Figure 1: A) Cbct Showing Multilocular Radiolucency From Mesial Of 32 To Distal Of 44 B) 3d Reconstruction Showing Perforation Omentioning

confidence: 99%

Malignant Odontogenic tumor: A case report

et al. 2020

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Malignant odontogenic tumors are rare and represent approximately 1% of all oral malignancies. Ameloblastic Carcinoma is an uncommon malignant odontogenic tumor accounting for 1.5%-2.0% of all odontogenic tumors that can be difficult to differentiate from Ameloblastoma, and can arise directly as an undifferentiated lesion or from a preexisting benign lesion. It is a highly aggressive tumor with rapid growth and a high potential for distant metastasis. The most common site of occurrence is posterior mandible. Here we present a case report of Ameloblastic Carcinoma, relapse case of a benign lesion 15 years after surgery which presented as firm growth in the right mandible for 2 months.

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“…Still, it is the most common malignancy among odontogenic tumours arising from the odontogenic epithelium [ 11 ]. It has an aggressive clinical course with extensive local destruction [ 12 ]. AC may arise de novo (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of AC arise de novo, and only a few cases of malignant transformations of pre-existing ameloblastomas have been described previously [ 14 – 16 ]. The clinical features of AC are similar to those of ameloblastoma [ 12 ]; the histopathological features include the lack of differentiation, hypercellularity, a high mitotic index, vascular invasion and neural invasion. Metastasis into cervical lymph nodes or other sites including vertebrae, pleura, the skull, the parotid glands, the diaphragm and the liver are typical for AC [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Metastasising ameloblastoma or ameloblastic carcinoma? A case report with mutation analyses

et al. 2023

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Background Ameloblastic carcinoma and metastasising ameloblastoma are rare epithelial odontogenic tumours with aggressive features. Distinguishing between these two lesions is often clinically difficult but necessary to predict tumour behaviour or to plan future therapy. Here, we provide a brief review of the literature available on these two types of lesions and present a new case report of a young man with an ameloblastoma displaying metastatic features. We also use this case to illustrate the similarities and differences between these two types of tumours and the difficulties of their differential diagnosis. Case presentation Our histopathological analyses uncovered a metastasising tumour with features of ameloblastic carcinoma, which developed from the ameloblastoma. We profiled the gene expression of Wnt pathway members in ameloblastoma sample of this patient, because multiple molecules of this pathway are involved in the establishing of cell polarity, cell migration or for epithelial–mesenchymal transition during tumour metastasis to evaluate features of tumor behaviour. Indeed, we found upregulation of several cell migration–related genes in our patient. Moreover, we uncovered somatic mutation BRAF p.V600E with known pathological role in cancerogenesis and germline heterozygous FANCA p.S858R mutation, whose interpretation in this context has not been discussed yet. Conclusions In conclusion, we have uncovered a unique case of ameloblastic carcinoma associated with an alteration of Wnt signalling and the presence of BRAF mutation. Development of harmful state of our patient might be also supported by the germline mutation in one FANCA allele, however this has to be confirmed by further analyses.

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Ameloblastic Carcinoma: A Rare Malignant Tumour in Maxillofacial Region

Cited by 5 publications

References 11 publications

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

Malignant Odontogenic tumor: A case report

Metastasising ameloblastoma or ameloblastic carcinoma? A case report with mutation analyses

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