Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats

Abstract

Background: Statins, HMG-CoA reductase inhibitors, are widely prescribed drugs for dyslipidemias. Recent studies have indicated number of cholesterol independent actions of statins including their beneficial effects on vascular endothelial dysfunction and memory deficits associated with dementia of Alzheimer's type. However the potential of statins in dementia of vascular origin still remains to be explored. Therefore, the present study has been designed to investigate the effect of Atorvastatin & Pitavastatin on vascular endothelial dysfunction associated memory deficits in rats. In this study L-Methionine induced vascular dementia was assessed by Morris water-maze (MWM) test. Biochemical analysis was also performed to unfold possible mechanism of statins mediated modulation of vascular dementia.

Hesperidin, a citrus flavonoid, protects against l -methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats

“…Therefore, with support from earlier literature review, the present study is designed to investigate the role of HSP in preventing cognitive decline, oxidative damage, ED and neuropathological alterations in hyperhomocysteinemic rats. The L-methioninetreated rats are mostly used for the assessment of HHcy and its secondary complications, including ED and VaD (Koladiya et al 2008;Sain et al 2011). HHcy has been reported to produce cognitive dysfunction (Streck et al 2004;Baydas et al 2005) and increase in the brain AChE activity (Stefanello et al 2007).…”

“…for 32 days) to induce HHcy-associated endothelial dysfunction and VaD (Shah & Singh 2007;Koladiya et al 2008Koladiya et al , 2009). …”

Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats

“…The preparation was primed with 80 mmol l −1 KCl to check its functional integrity and to improve its contractility. The cumulative dose responses of acetylcholine (ACh; 10 −8 to 10 −4 mol l −1 ) or sodium nitroprusside (SNP; 10 −8 to 10 −4 mol l −1 ) were recorded in phenylephrine (3 × 10 −6 mol l −1 ) precontracted preparations (Koladiya et al 2008;Sharma and Singh 2010). The intimal layer of aortic ring was rubbed gently with a moistened filter paper for 30 s to obtain endothelium-free preparations.…”

Neuroprotective Effect of Nevirapine on Cerebral Ischemic Stroke by Middle Cerebral Artery Occlusion in Wistar Rats

“…Changes in absorbance were recorded and the change in absorbance per minute was calculated. The enzyme activity is expressed as μmoles/minute/g tissue (Koladiya et al, 2008). …”