Ameliorative property of Kigelia africana crude and flavonoid leaf extracts on aluminum-induced hepatotoxicity in albino rats

Falode, John Adeolu; Akinmoladun, Afolabi Clement; Olaleye, Mary Tolulope

doi:10.1007/s00580-019-03004-y

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…Additionally, flavonoids prevent lipid peroxidation through their redox properties, as highlighted by their ability to provide electrons and hydrogen atoms. Additionally, they could act by chelating transition metals, such as copper and iron [56,57]. These last results confirmed the efficacy of the R. alaternus extract in reducing/preventing the adverse effects of AlCl 3 with an in vivo study.…”

Section: Discussionsupporting

confidence: 70%

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

et al. 2021

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Background This study was designed to evaluate the protective effects of a Rhamnus alaternus aqueous extract (RAAE) on aluminum chloride-induced hepatotoxicity in rats. A preliminary phytochemical study and antioxidant activity tests of the extract were performed. Methods A preliminary phytochemical study and antioxidant activity tests of the extract were performed. For the in vivo study, twenty-four male rats were divided into four groups. The control group (C); the RAAE group treated with 250 mg/kg b.w RAAE; the AlCl3 group, which received 50 mg/kg b.w AlCl3; and the AlCl3/RAAE group that was treated with AlCl3 plus RAAE. Results The RAAE contains several phenolic compounds. This plant extract showed a high radical scavenging effect and high antioxidant activity. Administration of AlCl3 resulted in a significant increase in the activities of aspartate aminotransferase and alanine aminotransferase (AST, ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and significant decreases in the plasma concentrations of total proteins and albumin. Moreover, AlCl3 induced a hepatic pro-oxidant effect leading to an increase in malonaldehyde (MDA) and carbonyl protein contents, the depletion of the content of reduced glutathione (GSH) and a decrease in the antioxidant enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). However, RAAE supplementation with AlCl3 treatment significantly decreased the levels of MDA and carbonyl proteins and markedly restored the activities of the antioxidant enzymes. These results are supported by the improvement in liver tissue restoration. Conclusions The Rhamnus alaternus aqueous extract was shown to have effective antioxidant activity owing to its phenolic compounds protecting against AlCl3-induced liver oxidative damage.

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Section: Discussionsupporting

confidence: 70%

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

et al. 2021

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“…The in vitro antioxidant and various radical scavenging activity of phytoextracts offer an insight into their potential biological effects in vivo . The antioxidant property of medicinal plants has been associated with their therapeutic potentials [ 6 , 23 , 68 , 69 ]. Multiple in vitro antioxidant tests such as carried out in this study are often employed to account for several antioxidant mechanisms exhibited by phytochemicals [ 25 , 40 , 43 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Reduction of anoxia-induced bioenergetic disturbance in astrocytes by methanol fruit extract of Tetrapleura tetraptera and in silico evaluation of the effect of its antioxidative constituents on excitotoxicity

et al. 2021

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“…Exposure to cement dust has been implicated as the major cause of silicosis and lung cancer. Individual involved either directly or indirectly in activities such as shearing, crushing, breaking or drilling of silica-based materials including concrete, tile, and stone in addition to building and construction workers are major culprits in this regard [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cement Dust Exposure on Indicators of Hepatic Function in Male Cement Handlers in Ekpoma, Nigeria

Festus

Agbebaku

Idonije

et al. 2021

EUROPEAN J MED ED TE

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Background:The rising cases of cancer and associated mobidity and mortality are indirectly linked to occupational health hazards especially in developing cases. This is further comounded by low level of compliance to safety health measures among factory workers. Ignorance and low-level of awareness on the associated health-implication of occupational risk exposure have been implicated in this regard. Methods:The present study was carried out to evaluate the effect of cement dust exposure on selected liver function parameters in cement handlers at Ekpoma, Nigeria. A total of 114 subjects comprising 57 with history of exposure to cement dust by means of their occupation or by means of livelihood for at least one (1) year, designated as cement handlers (CH) and another 57 non-cement handlers designated as control (CT). Blood sample was collected from the anti-cubital fossa vein of each participant by venipuncture first thing in the morning before the commencement of daily activity into lithium heparin anticoagulant bottles. Plasma bilirubin (conjugated, unconjugated and total) as well as AST, ALT, ALP activities were determined using standard colorimetric methods.Results: Bilirubin levels were altered significantly (p < 0.05), while ALT activity was significantly decreased (p < 0.05) in CH compared CT. AST and ALP activities were not significantly altered. Conclusion:The results presented in this study showed that exposure to cement dust led to markedly increased level of some liver function parameters in cement handlers. This is indicative of a compromised liver function due to hepatotoxicity.

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Ameliorative property of Kigelia africana crude and flavonoid leaf extracts on aluminum-induced hepatotoxicity in albino rats

Cited by 5 publications

References 52 publications

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

Reduction of anoxia-induced bioenergetic disturbance in astrocytes by methanol fruit extract of Tetrapleura tetraptera and in silico evaluation of the effect of its antioxidative constituents on excitotoxicity

Influence of Cement Dust Exposure on Indicators of Hepatic Function in Male Cement Handlers in Ekpoma, Nigeria

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