Ameliorative Potentials of Nymphaea Alba on Hepatotoxicity and Oxidative Damage Induced by Chronic Exposure to Isoniazid in Rats

Nasiruddin, Mohammad; Khan, Irfan; Arif, Sayeedul Hasan

doi:10.7897/2230-8407.1007219

Cited by 2 publications

(1 citation statement)

References 15 publications

(17 reference statements)

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“…142,143 There are many phyto-constituents such as ellagic and Gallic acid, quercetin, kaempferol, isokaempferide, apigenin and their glycosides have been identified in the flowers Nymphaea alba L. The hepatoprotective effect of N. alba against CCl 4 -induced hepatotoxicity was studied and found good hepatoprotective agent. 144 It has also been reported to have ameliorative effect against isoniazid induced hepatotoxicity in rats. 145 The significant reduction in biochemical parameters (SGOT, SGPT, ALP, Bilirubin) and cholesterol level as compared to control group was seen after administration of ethanolic extract (200 and 400 mg/kg) of Nymphaea alba.…”

Section: Nymphaea Alba (Family: Nymphaeaceae)mentioning

confidence: 99%

Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Shakya¹

2020

IJPER

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The Liver, a paramount organ is the Chief site for metabolism of nutrients and energy production in the human body. It is also necessary for metabolism and elimination of exogenous drugs and harmful substances via kidney. Hepatotoxicity caused by a variety of environmental pollutants, pathogenic micro-organism, viruses, drugs and chemical agents may account for various hepatic diseases such as jaundice, necrosis, hepatitis, fibrosis and cirrhosis etc. Ayurveda is a traditional medicinal system of India and is being practiced continuously since ancient times and at present for the treatment of various human diseases. Medicinal plants as a significant source of therapeutic compounds used for the development of effective drugs against a variety of human diseases include liver ailments. Hence, therapeutic plants are becoming popular in the pharmaceutical industry to develop a safe and effective medicine for the treatment of the emerging new human diseases. Therefore, the present review is aimed to compiling data on hepatoprotective medicinal plants which have been investigated against drug-induced hepatotoxicity.

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Section: Nymphaea Alba (Family: Nymphaeaceae)mentioning

confidence: 99%

Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Shakya¹

2020

IJPER

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Elderly People from Old Age Homes have Higher Risk of Malnutrition and Depression as Compared to Family Setup

Kumari

Sindhu

Dhami

et al. 2022

IJND

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With increase in average age of population and increasing trend of nuclear families, old age homes are fast becoming a norm in India. The COVID-19 pandemic has made nutritionists revisit the health status of our elderly living in different family set ups. The present study was carried out with the objective to compare the health and risk of malnutrition among elderly (? 60 yrs in age) living in three different residential set ups i.e. old age homes, urban family or rural family. The study was carried out in Hisar district of Haryana state in Northern India. In this cross-sectional study, sixty subjects each (N=180) from the three residential set ups were selected randomly and assessed for depression, level of independence in daily activities and risk for malnutrition. Standard scales viz. Geriatric Depression Scale, Barthel Index and Mini Nutritional Assessment Scale were used. The PAR (Physical Activity Ratio) values for activities performed in a day were aggregated over the period i.e. 24 hours to yield physical activity level. It was observed that respondents from rural family set up were more active as compared to their counterparts in urban family set up or old age homes. Osteoporosis (94.44%), joint pain (87.78%), loss of appetite (85.56%) and anemia (80.56%) were the most commonly reported problems. Per cent prevalence of most problems was higher in old age home respondents. The level of independence for most activities was lowest in old age home respondents as compared to other two residential set ups. Depression was evident in 36.67 per cent of total respondents with higher per cent prevalence in residents of old age home. It may be concluded that elderly people from old age homes have higher risk of malnutrition and depression as compared to urban or rural family setup. Interventions are highly recommended for mental and nutritional well-being of elderly specially those living in old age homes. Considering the increasing trend of old age homes, deeper studies are required on their living conditions. There should be stringent SOP’s for all old age homes and elderly care.

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Ameliorative Potentials of Nymphaea Alba on Hepatotoxicity and Oxidative Damage Induced by Chronic Exposure to Isoniazid in Rats

Cited by 2 publications

References 15 publications

Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

Elderly People from Old Age Homes have Higher Risk of Malnutrition and Depression as Compared to Family Setup

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