2019
DOI: 10.7897/2230-8407.1007219
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Ameliorative Potentials of Nymphaea Alba on Hepatotoxicity and Oxidative Damage Induced by Chronic Exposure to Isoniazid in Rats

Abstract: Objective: Evaluation of hepatoprotective and antioxidant potentials of ethanolic extract of Nymphaea alba against chronic exposure to isoniazid in rats. Material and Methods: Chronic administration of isoniazid (50 mg/kg) orally for 28 days lead to hepatotoxicity in rats. Silymarin (50 mg/kg) and ethanolic extract of Nymphaea alba flowers and leaves (200 mg/kg and 400 mg/kg) were given orally for 31 days. Isoniazid was given to all rats except normal control from 4 th to the 31 st day of the study. On the 32 … Show more

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“…142,143 There are many phyto-constituents such as ellagic and Gallic acid, quercetin, kaempferol, isokaempferide, apigenin and their glycosides have been identified in the flowers Nymphaea alba L. The hepatoprotective effect of N. alba against CCl 4 -induced hepatotoxicity was studied and found good hepatoprotective agent. 144 It has also been reported to have ameliorative effect against isoniazid induced hepatotoxicity in rats. 145 The significant reduction in biochemical parameters (SGOT, SGPT, ALP, Bilirubin) and cholesterol level as compared to control group was seen after administration of ethanolic extract (200 and 400 mg/kg) of Nymphaea alba.…”
Section: Nymphaea Alba (Family: Nymphaeaceae)mentioning
confidence: 99%
“…142,143 There are many phyto-constituents such as ellagic and Gallic acid, quercetin, kaempferol, isokaempferide, apigenin and their glycosides have been identified in the flowers Nymphaea alba L. The hepatoprotective effect of N. alba against CCl 4 -induced hepatotoxicity was studied and found good hepatoprotective agent. 144 It has also been reported to have ameliorative effect against isoniazid induced hepatotoxicity in rats. 145 The significant reduction in biochemical parameters (SGOT, SGPT, ALP, Bilirubin) and cholesterol level as compared to control group was seen after administration of ethanolic extract (200 and 400 mg/kg) of Nymphaea alba.…”
Section: Nymphaea Alba (Family: Nymphaeaceae)mentioning
confidence: 99%