Ameliorative potentials of cocoyam (Colocasia esculenta L.) and unripe plantain (Musa paradisiacal L.) on renal and liver growth in streptozotocin induced diabetic rats

Eleazu, Chinedum; Iroaganachi, M; Kc, Eleazu

doi:10.1016/s2221-6189(13)60115-8

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…In our previous studies [5,6], we reported the ameliorating potentials of ginger, cocoyam and unripe plantain flours on relative tissue weights and renal growths in streptozotocin induced diabetic rats but we did not report their ameliorating actions on relative pancreatic weight.…”

Section: Introductionmentioning

confidence: 73%

“…The reduction in the body weight of the diabetic animals could be explained on the basis of loss of structural proteins as these structural proteins contribute to body weight [5].…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids, alkaloids, tannins and flavonoids, as polyphenolic compounds, have been associated with hypoglycemic activity [15,5].…”

Section: Discussionmentioning

confidence: 99%

“…Plantain (M. paradisiaca) belongs to the "Musacae" family and its cultivated in many tropical and subtropical countries of the world. Scientifically, unripe plantain has been documented as a hypoglycemic plant [5] although its mechanism of hypoglycemic action remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Potentials of Cocoyam (Colocasia Esculenta L.) and Unripe Plantain (Musa Paradisiacal L.) in Renal and Liver Growth in Streptozotocin Induced Diabetic Rats

Co¹,

Kc²

2013

J Diabetes Metab

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The ameliorating potentials of cocoyam (Colocasia esculenta L.), ginger (Z.officinale Roscoe) and unripe plantain (Musa paradisiacae L.) incorporated feeds on the relative pancreatic weights of streptozotocin induced diabetic rats was investigated. The blood glucose level of all the rats was measured with a glucometer, the assay of the phytochemical and crude fibre compositions of the test feeds were carried out using standard techniques. The administration of the test feeds for 21 days to the diabetic rats of groups 5 to 7, resulted in 58.75%, 29.81% and 38.13% decreases in their hyperglycemia. Administration of the cocoyam incorporated feeds to the diabetic rats of group 5, resulted in 2.71% and 19.52% increases in their body weights and growth rates respectively, administration of the ginger incorporated feeds to the diabetic rats of group 6, resulted in 9.88% and 60.24% increases in their body weights and growth rates, unlike the diabetic rats of group 7, administered unripe plantain feed that had 5.12% decrease in weight with a corresponding 29.52% decrease in growth rate but higher than the diabetic control rats that recorded 28.69, 28.62% and 29.46% decreases in body weights with corresponding 248.9%, 239.9% and 250.14% decreases in growth rates. Chemical analysis of the test feeds indicate that they contained considerable amounts of phytochemicals and crude fibre. Results indicate the ability of cocoyam, ginger and unripe plantain to ameliorate the relative pancreatic weight of diabetics.

show abstract

Section: Introductionmentioning

confidence: 73%

“…The reduction in the body weight of the diabetic animals could be explained on the basis of loss of structural proteins as these structural proteins contribute to body weight [5].…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids, alkaloids, tannins and flavonoids, as polyphenolic compounds, have been associated with hypoglycemic activity [15,5].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ameliorative Potentials of Cocoyam (Colocasia Esculenta L.) and Unripe Plantain (Musa Paradisiacal L.) in Renal and Liver Growth in Streptozotocin Induced Diabetic Rats

Co¹,

Kc²

2013

J Diabetes Metab

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“…The ameliorative potential of C. esculenta tubers on renal and liver growths in streptozotocin diabetic rats has been reported [22] [24]. The antihyperglycemic activity of petroleum ether extract of leaves of Ficus krishnae has been reported; the crude extract was found to contain alkaloids, fl avonoids, and tannins [25].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Action in Oral Glucose Tolerance Tests between Spilanthes Calva Aerial Parts and Tubers of Colocasia Esculenta

Bhuiyan¹,

Nahar²,

Hossain³

et al. 2016

Int J Pharm Sci Dev Res

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Introduction: Diabetes is a debilitating disease characterized by elevated blood glucose levels, which is rapidly r eaching endemic proportions throughout the world including Bangladesh. We had previously evaluated the antihyperglycemic potential of methanolic extract of aerial parts of Spilanthes calva and tubers of Colocasia esculenta. The objective of this study was to determine whether there is any synergistic antihyperglycemic activity between the methanolic extracts of the plant parts of the two plants.Methods: Antihyperglycemic activity and synergistic potential were determined through oral glucose tolerance tests (OGTT) in mice.Result: Administration of methanolic extract of aerial parts of S. calva (MESC) at a dose of 400 mg per kg body weight led to lowering of blood glucose levels in glucose-loaded mice in OGTT by 41.6%. At the same dose, methanolic extract of tubers of C. esculenta (MECE) lowered blood glucose levels by 25.1%. At doses of 100, 200 and 400 mg each of (MESC + MECE), blood glucose levels in mice were lowered, respectively, by 38.8, 43.0, and 49.5%. At the highest dose of the combination, the reductions in blood glucose were comparable to that of a standard antihyperglycemic drug, glibenclamide, which when administered at a dose of 10 mg per kg lowered blood glucose by 52.2%. Conclusion:Synergistic antihyperglycemic activity was observed between aerial parts of S. calva and tubers of C. esculenta in oral glucose tolerance tests. The combination has the potential to be a substitute for glibenclamide.

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Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.

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Ameliorative potentials of cocoyam (Colocasia esculenta L.) and unripe plantain (Musa paradisiacal L.) on renal and liver growth in streptozotocin induced diabetic rats

Cited by 8 publications

References 25 publications

Ameliorative Potentials of Cocoyam (Colocasia Esculenta L.) and Unripe Plantain (Musa Paradisiacal L.) in Renal and Liver Growth in Streptozotocin Induced Diabetic Rats

Ameliorative Potentials of Cocoyam (Colocasia Esculenta L.) and Unripe Plantain (Musa Paradisiacal L.) in Renal and Liver Growth in Streptozotocin Induced Diabetic Rats

Synergistic Action in Oral Glucose Tolerance Tests between Spilanthes Calva Aerial Parts and Tubers of Colocasia Esculenta

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

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