Ameliorative effects of the phytochemicals in dates (Phoenix dactylifera) against the toxicological changes induced by fipronil in male albino rats

Abdelhafez, Hossam El Din H.; Abdallah, Amr A.; El‐Dahshan, Asmaa A.; El-baset, Yasser A. Abd; Morsy, Osama M.; Ahmed, Mohamed

doi:10.1016/j.tox.2022.153313

Toxicology

2022

DOI: 10.1016/j.tox.2022.153313

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Ameliorative effects of the phytochemicals in dates (Phoenix dactylifera) against the toxicological changes induced by fipronil in male albino rats

Hossam El Din H. Abdelhafez

Amr A. Abdallah²,

Asmaa A. El‐Dahshan³

et al.

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2024

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“…Acetamiprid's disruption of crucial signaling pathways in neurons may trigger apoptosis, resulting in cellular demise and possibly playing a role in neurodegenerative disorders (12). Like other neonicotinoid compounds, acetamiprid inhibits AChE, accumulating acetylcholinesterase at the cholinergic synapses, inducing neurotoxicity, and eventual neurodegeneration (14).…”

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The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex

Albrakati

2024

Front. Vet. Sci.

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Acetamiprid is a class of neuroactive insecticides widely used to control insect pests. The current study aimed to investigate the potential neuroprotective effects of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex. Four equal groups of adult male rats (10 in each): control, acetamiprid (40 mg/kg for 28 days), luteolin (50 mg/kg for 28 days), and acetamiprid+luteolin cotreatment were used. Acetamiprid was shown to alter the oxidative state by increasing oxidant levels [nitric oxide (NO) and malondialdehyde (MDA)] and decreasing antioxidants [glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase-(CAT)], with increased activity of nuclear factor erythroid 2–related factor 2-(Nrf2). Likewise, acetamiprid increases the inflammatory response, as evidenced by increased interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nuclear factor kappa B-(NF-κB). In contrast, the treatment with luteolin brought these markers back to levels close to normal, showing that it protects neurocytes from oxidative damage and the neuroinflammation effects of acetamiprid-induced inflammation. Luteolin also demonstrated a neuroprotective role via the modulation of acetylcholinesterase (AChE) activity in the cerebral cortex tissue. Histopathology showed severe neurodegenerative changes, and apoptotic cells were seen in the acetamiprid-induced cerebral cortex layer, which was evident by increased protein expression levels of Bax and caspase-3 and decreased Bcl-2 levels. Histochemistry confirmed the neuronal degeneration, as proven by the change in neurocyte colour from brown to black when stained with a silver stain. Luteolin may have a neuroprotective effect against biochemical and histopathological changes induced by acetamiprid in the rat cerebral cortex.

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confidence: 99%

The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex

Albrakati

2024

Front. Vet. Sci.

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Ameliorative effects of the phytochemicals in dates (Phoenix dactylifera) against the toxicological changes induced by fipronil in male albino rats

Cited by 1 publication

References 67 publications

The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex

The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex

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