Ameliorative Effects of the Methanolic Extract of the Rind of Citrullus lanatus on Lead Acetate Induced Toxicity on Semen Parameters and Reproductive Hormones of Male Albino Wistar Rats

Kolawole, T

doi:10.9734/ejmp/2014/11011

Cited by 12 publications

(13 citation statements)

References 20 publications

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“…Lead exposure causes renal dysfunction, liver cirrhosis, damage to the cardiovasculer system and anemia (3). It can also cause some pathological damages in the ovaries and testes, causes by poor reproductive performance (4). Elimination of lead from tissues is slowly.…”

Section: Introductionmentioning

confidence: 99%

Effect of pomegranate (Punica granatum L.) juice on kidney, liver, heart and testis histopathological changes, and the tissues lipid peroxidation and antioxidant status in lead acetate-treated rats

Aksu

Sağlam

Yıldırım

et al. 2017

Cell Mol Biol (Noisy-le-grand)

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Pomegranate juice (PJ) contains relevant amounts of active biological compounds which alleviate the detrimental effects of chronic heavy metal exposure. This study investigated the protective potential of PJ against lead-induced oxidative stress. A total of forty adult male Sprague Dawley rats were divided into four experimental groups. The animals were fed a standard pellet diet and tap water ad libitum. The rats were divided into four groups (n=10 for each group): control, lead asetat (2000 ppm), low-treated PJ- a daily dose of 2.000 ppm lead plus 30µl pomegranate juice (included 1.050 µmol total polyphenols, gallic acid equivalent), and high-treated PJ- a daily dose of 2.000 ppm lead plus 60µl pomegranate juice (included 2.100 µmol total polyphenols, gallic acid equivalent). The treatments were delivered for 5 weeks. After the treatment period, the tissues samples (kidney, liver, heart and testis) were collected. Tissue lead (Pb) and mineral amounts (copper, zinc, and iron), tissues lipid peroxidation level and antioxidant status, and tissues histopathological changes were determined. The results showed that the highest rate lead loading was in the kidney and the testis. Pomegranate juice was decreased the lead levels of soft tissues examined; increased Zn amounts in tissues of which the lead accumulation was higher (kidney and the testis); decreased the copper, zinc and the iron levels of the liver and heart tissues, without creating a weakness in antioxidant capacity of these tissues, restricted the oxidative stress by decreasing lipid peroxidation, improved both of the activities of antioxidant enzymes such as superoxide dismutase (SOD) and catalaz (CAT), and the level of glutathione (GSH) in all the tissues examined in lead-treated groups. As histopathological findings, the cellular damage induced by lead in the tissues of the kidney, liver and the heart were observed to have been partially prevented by PJ treatment. The protective effect of PJ was more pronounced in the testis compared to those others.

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Section: Introductionmentioning

confidence: 99%

Effect of pomegranate (Punica granatum L.) juice on kidney, liver, heart and testis histopathological changes, and the tissues lipid peroxidation and antioxidant status in lead acetate-treated rats

Aksu

Sağlam

Yıldırım

et al. 2017

Cell Mol Biol (Noisy-le-grand)

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“…8 In a recent report from our center, we described the possible ameliorative effects of the methanolic extract of the rind of Citrullus lanatus on semen parameters and reproductive hormones following lead acetate induced toxicity in male wistar rats. 9 Plant based medicines are now considered as better alternatives to control and treatment of various diseases; because of safety considerations since they have minimal side effects likely due to the presence of naturally occurring ingredients. 10 On account of these, the present study attempted to evaluate the methanolic extract of the rind of Citrullus lanatus for possible benefit in indomethacin induced gastric ulceration using male Wistar rats as models.…”

Section: Introductionmentioning

confidence: 99%

Gastro-protective effects of the methanolic extract of the rind of citrullus lanatus on indomethacin induced gastric ulceration in male wistar rats

Kolawole¹,

Dapper²

2017

actapharm

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“…Tetapi perlakuan P1 memiliki hasil rataan lebih rendah serta tidak berbeda nyata terhadap K(-) sebagai kontrol negatif. Kolawole et al (2014) menyatakan bahwa dengan dosis efektif sebesar 40mg/ekor/hari dapat meningkatkan kualitas spermatozoa tikus dibandingkan dengan kontrol negatif tanpa diberi paparan suhu panas. Berdasarkan hasil penelitian ini perlakuan P1 dapat meningkatkan keutuhan membran plasma spermatozoa meski belum dapat mengembalikan pada keadaan normal tanpa paparan.…”

Section: Hasil Dan Pembahasan Keutuhan Membran Plasma Spermatozoaunclassified

PENGARUH PEMBERIAN EKSTRAK KULIT BAGIAN DALAM SEMANGKA (Citrullus lanatus) TERHADAP KEUTUHAN MEMBRAN PLASMA DAN ABNORMALITAS MORFOLOGI TIKUS JANTAN (Rattus norvegicus) SETELAH DIPAPAR SUHU PANAS

Reisinta¹,

L²,

Hernawati³

et al. 2020

Ovz

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This study aims to determined the effect of watermelon’s inner rind extract (Citrullus lanatus) towards the integrity of the plasma membrane and morphological abnormalities of male Norway rats’s spermatozoa (Rattus norvegicus) after being exposed to hot temperature. The content of lycopene in the inner rind of watermelon serves an antioxidant counteracting free radicals. A total of 20 male Norway rats (Rattus norvegicus) were used in this study with an average age of 2 months. The study was divided into five treatments and four replications, consisting of: K(-) as negative control given CMC Na 0.5% as much as 0.5 ml, P0 as positive control was exposed to 40° C for 1 hour and CMC Na 0.5% of 0.5 ml. P1, P2 and P3 are exposed to 40° C for 1 hour and inner rind extracts of watermelon with a multilevel dose of P1: 20mg/head/day, P2: 40mg/head/day, and P3: 80mg/head/day that each dose was dissolved in CMC Na 0.5% of 0.5 ml. The results showed that giving inner rind extract of watermelon to the rats increased the integrity of the plasma membrane and decreased morphological abnormalities of male rat’s spermatozoa (Rattus norvegicus). The result of increased the integrity of the plasma membrane and highest decreased morphological abnormality was shown by P3 group given a dose of 80 mg/head/day.

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Ameliorative Effects of the Methanolic Extract of the Rind of Citrullus lanatus on Lead Acetate Induced Toxicity on Semen Parameters and Reproductive Hormones of Male Albino Wistar Rats

Cited by 12 publications

References 20 publications

Effect of pomegranate (Punica granatum L.) juice on kidney, liver, heart and testis histopathological changes, and the tissues lipid peroxidation and antioxidant status in lead acetate-treated rats

Effect of pomegranate (Punica granatum L.) juice on kidney, liver, heart and testis histopathological changes, and the tissues lipid peroxidation and antioxidant status in lead acetate-treated rats

Gastro-protective effects of the methanolic extract of the rind of citrullus lanatus on indomethacin induced gastric ulceration in male wistar rats

PENGARUH PEMBERIAN EKSTRAK KULIT BAGIAN DALAM SEMANGKA (Citrullus lanatus) TERHADAP KEUTUHAN MEMBRAN PLASMA DAN ABNORMALITAS MORFOLOGI TIKUS JANTAN (Rattus norvegicus) SETELAH DIPAPAR SUHU PANAS

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