Ameliorative effects of taurine against diabetes: a review

Inamullah, .; Piao, Fengyuan; Aadil, Rana Muhammad; Suleman, Raheel; Li, Kaixin; Zhang, Mengren; Wu, Pingan; Shahbaz, Muhammad; Ahmed, Zulfiqar

doi:10.1007/s00726-018-2544-4

Cited by 53 publications

(25 citation statements)

References 187 publications

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“…Significant increases in taurine levels have been consistently observed after intake of glucose or sugar-sweetened beverages in previous studies [ 43 , 44 ]. Indeed, an in vivo study showed that taurine could improve glucose homeostasis by reducing the synthesis of AGEs or preventing mitochondrial dysfunction in β-cells [ 45 ]. Of note, the increase in levels of another metabolite, 5′-methylthioadenosine, could be explained by activation of adenosylmethionine synthase upon glucose intake and upregulated conversion of S-adenosylmethionine to 5′-methylthioadenosine [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

et al. 2021

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Little is known about changes in plasma metabolome profiles during the oral glucose tolerance test (OGTT) in Chinese. We aimed to characterize plasma metabolomic profiles at 0 and 2 h of OGTT and their changes in individuals of different glycemic statuses. A total of 544 metabolites were detected at 0 and 2 h of OGTT by a nontarget strategy in subjects with normal glucose (n = 234), prediabetes (n = 281), and newly diagnosed type 2 diabetes (T2D) (n = 66). Regression model, mixed model, and partial least squares discrimination analysis were applied. Compared with subjects of normal glucose, T2D cases had significantly higher levels of glycerone at 0 h and 22 metabolites at 2 h of OGTT (false discovery rate (FDR) < 0.05, variable importance in projection (VIP) > 1). Seven of the twenty-two metabolites were also significantly higher in T2D than in prediabetes subjects at 2 h of OGTT (FDR < 0.05, VIP > 1). Two hours after glucose challenge, concentrations of 35 metabolites (normal: 18; prediabetes: 23; T2D: 13) significantly increased (FDR < 0.05, VIP > 1, fold change (FC) > 1.2), whereas those of 45 metabolites (normal: 36; prediabetes: 29; T2D: 18) significantly decreased (FDR < 0.05, VIP > 1, FC < 0.8). Distinct responses between cases and noncases were detected in metabolites including 4-imidazolone-5-acetate and 4-methylene-L-glutamine. More varieties of distinct metabolites across glycemic statuses were observed at 2 h of OGTT compared with fasting state. Whether the different patterns and responsiveness of certain metabolites in T2D reflect a poor resilience of specific metabolic pathways in regaining glucose homeostasis merits further study.

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Section: Discussionmentioning

confidence: 99%

Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

et al. 2021

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“…The beneficial effects of taurine have been demonstrated in many diseases such as decreased serum low-density lipoprotein, decreased progression of atherosclerosis, and protection against ischemiareperfusion injury of the myocardium (Schaffer and Kim 2018;Xu et al 2008;Abebe and Mozaffari 2011;Lambert et al 2015;De Luca et al 2015). Besides, the beneficial effects of taurine in diabetic cardiovascular complications are well documented (Franconi et al 1995(Franconi et al , 2004Inam-U-Llah et al 2018;Lewis et al 2014;Manna et al 2013;Tappia et al 2011Tappia et al , 2013Tappia et al , 2018Turan 2010). It has been suggested that taurine increases the high-energy phosphate content of the heart (Schaffer and Kim 2018;Schaffer et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Taurine and cardiac disease: state of the art and perspectives

Bkaily

Jazzar

Normand

et al. 2020

Can. J. Physiol. Pharmacol.

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Taurine is a nonessential amino acid that has received much attention. Two organs, the heart and the brain, are known to produce their own taurine, but in very limited quantities. It is for this reason that supplementation with this amino acid is necessary. Today, taurine is present in almost all energy drinks. A very vast literature reported beneficial effects of taurine in hepatic dysfunction, gastrointestinal injury, kidney diseases, diabetes, and cardiovascular diseases. Most of its effects were attributed to its modulation of Ca2+ homeostasis as well as to its antioxidant properties. In this review, we will focus on the current status of taurine modulation of the cardiovascular system and discuss future avenues for its use as a supplement therapy in a specific cardiovascular disease, namely hypertrophy, and heart failure.

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“…Interestingly, recent results demonstrate that Tau depletion could impair ammonia detoxification in mouse livers, associated with oxidative stress and senescence [ 29 ]. On the other hand, dietary supplementation of Tau was shown to be associated with a reduction in the risk of various diseases, including diabetes [ 30 , 31 ], metabolic syndrome [ 32 ], skeletal muscle disorders [ 33 ], retinal degeneration [ 23 ], atherosclerosis [ 34 ], liver diseases [ 35 ], central nervous system disorders [ 36 ], etc.…”

Section: Taurine Essentiality and Requirementmentioning

confidence: 99%

Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

2021

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Natural antioxidants have received tremendous attention over the last 3 decades. At the same time, the attitude to free radicals is slowly changing, and their signalling role in adaptation to stress has recently received a lot of attention. Among many different antioxidants in the body, taurine (Tau), a sulphur-containing non-proteinogenic β-amino acid, is shown to have a special place as an important natural modulator of the antioxidant defence networks. Indeed, Tau is synthesised in most mammals and birds, and the Tau requirement is met by both synthesis and food/feed supply. From the analysis of recent data, it could be concluded that the direct antioxidant effect of Tau due to scavenging free radicals is limited and could be expected only in a few mammalian/avian tissues (e.g., heart and eye) with comparatively high (>15–20 mM) Tau concentrations. The stabilising effects of Tau on mitochondria, a prime site of free radical formation, are characterised and deserve more attention. Tau deficiency has been shown to compromise the electron transport chain in mitochondria and significantly increase free radical production. It seems likely that by maintaining the optimal Tau status of mitochondria, it is possible to control free radical production. Tau’s antioxidant protective action is of great importance in various stress conditions in human life, and is related to commercial animal and poultry production. In various in vitro and in vivo toxicological models, Tau showed AO protective effects. The membrane-stabilizing effects, inhibiting effects on ROS-producing enzymes, as well as the indirect AO effects of Tau via redox balance maintenance associated with the modulation of various transcription factors (e.g., Nrf2 and NF-κB) and vitagenes could also contribute to its protective action in stress conditions, and thus deserve more attention.

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Ameliorative effects of taurine against diabetes: a review

Cited by 53 publications

References 187 publications

Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

Taurine and cardiac disease: state of the art and perspectives

Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

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