Ameliorative Effects of Resveratrol on Oxidative Stress Biomarkers in Horses

Ememe, M. U.; Mshelia, Wayuta Philip; Ayo, Joseph Olusegun

doi:10.1016/j.jevs.2015.02.006

Cited by 18 publications

(10 citation statements)

References 51 publications

(45 reference statements)

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“…It is possible that the dose of resveratrol administered to horses in this study (450 mg twice daily) was not sufficient to exert an immunomodulatory effect on the measured parameters. All other in vivo equine studies employed a different commercially available resveratrol supplement, and the total dose per day was somewhat higher compared to the manufacturer's recommendations for the supplement used in our study [23][24][25][26][27][28][29]. The formulation of the resveratrol supplement might be a contributing factor to effect (or lack thereof) because of the poor solubility and bioavailability of resveratrol, creating a major challenge for the pharmaceutical industry [36].…”

Section: Discussionmentioning

confidence: 92%

“…Although the use of resveratrol as a nutraceutical with numerous purported but unproven benefits for equine health has been gaining acceptance in recent years, published studies reporting anti-inflammatory or analgesic effects in horses are few [23][24][25][26][27][28][29]. In one study of performance horses affected with distal tarsitis, oral resveratrol supplementation used in conjunction with an intra-articular corticosteroid resulted in reduced lameness when compared to intra-articular corticosteroid and an orally administered placebo [28].…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, a reduction in basal serum TNF-α concentrations was reported following treatment of horses affected with Equine Metabolic Syndrome [30,31] with resveratrol [23]. Modulation of important antioxidant biomarkers, including reductions in malondialdehyde concentration and activity of glutathione peroxidase and increased superoxide dismutase and catalase activities, was demonstrated following the oral administration of resveratrol to horses affected with age-related osteoarthritis [24].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study

Martin¹,

Johnson²,

Amorim³

et al. 2020

IJMS

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Resveratrol, a phytophenol, is a commonly used equine nutraceutical supplement touted to exert anti-inflammatory effects. The effect of orally administered resveratrol on tumor necrosis factor (TNF), interleukin-1β (IL-1β), leukocyte phagocytic activity or oxidative burst function have not been reported in horses. The objective of this study was to determine the effects of a commercially available, orally administered resveratrol product on innate immune functions in healthy adult horses. Whole blood was collected from 12 horses prior to and following 3 weeks of treatment with either the manufacturer’s recommended dose of resveratrol or placebo. Phagocytosis, oxidative burst and pathogen associated molecular pattern (PAMP) motif-stimulated leukocyte production of TNF and IL-1β were compared pre- and post-treatment between treatment groups. Phagocytosis and oxidative burst capacity were evaluated via flow cytometry. Tumor necrosis factor and IL-1β were measured using cytotoxicity and ELISA assays, respectively. There were no significant differences in phagocytosis, oxidative burst or stimulated TNF or IL-1β production between resveratrol and placebo treatment groups. Orally administered resveratrol at a routinely recommended dose for a duration of 3 weeks did not significantly affect phagocytic activity, oxidative burst function or PAMP-stimulated leukocyte cytokine production.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study

Martin¹,

Johnson²,

Amorim³

et al. 2020

IJMS

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“…The result showed higher percentage of riders who reported better performance of their horses. Ememe et al [84] also reported that administration of equithrive joint to aged and lame horses decreased the serum MDA concentration and modulated the serum content of GPx, catalase, and SOD. The results suggested a potential protective effect of equithrive joint against oxidative stress and aging in Figure 3.…”

Section: Resveratrol Studies In Horsesmentioning

confidence: 96%

Evaluation of Resveratrol Supplementation on Laboratory Animals, Cats, Pigs, Horses, Dogs, Cattle, and Birds

Ememe¹,

Sackey²,

Ayo³

2019

Resveratrol - Adding Life to Years, Not Adding Years to Life

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This chapter evaluated resveratrol supplementation on laboratory animals, cats, pigs, horses, dogs, cattle and birds. Resveratrol (3, 5, 4′-trihydroxystilbene) is a stilbenoid, a derivate of stilbene. It is found in some plants such as red grape, grape products, cocoa, peanuts, raspberries, mulberries, strawberry and Japanese knotweed roots. The most important dietary source of resveratrol is red wine, and it is often assumed to be an important factor in the French Paradox, a term used to describe the observation that the French population has a very low incidence of cardiovascular disease, despite a diet high in saturated fats. Research has shown some therapeutic effects of resveratrol ranging from antioxidant, anti-inflammatory, cardioprotective, antiatherogenic, antiaging, antiplatelet aggregation, anticancer, antidiabetic, antitumor, and immunomodulatory activities. In laboratory animals, benefits of resveratrol comprise antitumor effects while in cats it has shown to improve hepatic function. In pigs, the antibiotic and antiviral effects of resveratrol have been illustrated. The anti-inflammatory and antioxidative properties of resveratrol in horses and cattle were also reviewed. The supplement was shown to be useful as an antibiotic and an aid in improving alertness in dogs. Resveratrol also showed to increase growth performance in birds. It is therefore concluded that use of resveratrol is a potent aid in improving animal production and health.

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“…A decrease in both creatine kinase and glucose levels in horses receiving resveratrol and hyaluronic acid (EquithriveJoint ® ) was found [30]. EquithriveJoint ® was administered to old, lame horses and a decreased serum malondialdehyde (MDA) concentration and modulated serum levels of glutathionperoxidase (GPx), catalase and superoxiddismutase (SOD) were found, indicating protective effects of EquithriveJoint ® against oxidative stress and ageing [31]. A beneficial effect of EquithriveJoint ® on the performance of horses with hindlimb lameness treated with triamcinolone was also demonstrated [32].…”

Section: Introductionmentioning

confidence: 99%

Effects of Knotweed-Enriched Feed on the Blood Characteristics and Fitness of Horses

et al. 2022

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The aboveground biomass of dry knotweed was administered daily to large groups of young (1- to 3-year-old) stallions of the Czech Warmblood, Czech-Moravian Coldblood and Silesian Norik breeds, fed individually for 4 and 6 months in two successive winter experiments. Their fitness was compared with control groups consisting of equally numerous subgroups comparable in age, breed, body mass and initial blood parameters. The effects of knotweed on the horses’ fitness were evaluated based on changes in blood characteristics. Even if administered in small amounts, 150 g per day, knotweed could (1) increase the thrombocyte numbers, (2) increase the globulin content (thus improving the horses’ immunity, which is desired in large groups of animals), (3) stimulate lipid metabolism in cold-blooded horses and (4) decrease the concentration of cholesterol. The long-lasting effect of knotweed on both the urea and triglyceride–cholesterol ratio presumably reflected, between the two experiments, the temporary protein starvation of horses on pastures with poor quality of grass in a dry summer.

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Ameliorative Effects of Resveratrol on Oxidative Stress Biomarkers in Horses

Cited by 18 publications

References 51 publications

Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study

Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study

Evaluation of Resveratrol Supplementation on Laboratory Animals, Cats, Pigs, Horses, Dogs, Cattle, and Birds

Effects of Knotweed-Enriched Feed on the Blood Characteristics and Fitness of Horses

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