Ameliorative Effects of Pomegranate Peel Extract on Hepatotoxicity Induced by Carbon Tetrachloride in Mice

doi:10.20431/2349-0365.0410005

International Journal of Research Studies in Biosciences

2016

DOI: 10.20431/2349-0365.0410005

|View full text |Cite

Ameliorative Effects of Pomegranate Peel Extract on Hepatotoxicity Induced by Carbon Tetrachloride in Mice

Abstract: Abstract:Pomegranate peel extracts (PPE) In conclusion, our results demonstrated that PPE through its antioxidant action efficiently improve the liver toxicity induced by CCl4.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 32 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

The Effects of Pomegranate Seed Oil on Chronic Liver Damage Induced Carbon Tetrachloride in Rats and Determination of Hepatic Apoptosis and Caspase Activity

Ekebaş¹,

Atasever²,

Şentürk

et al. 2020

Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

Bu çalışmada, karbon tetrakloru r (CCl4) ile kronik karaciğ er hasarı oluşturulan ratlarda nar çekirdeğ i yağ ının (NÇY) karaciğ er dokusunda oluşabilecek lezyonlar u zerine koruyucu etkisi ve biyokimyasal değ erleri araştırılmıştır.Çalışmada 32 adet, her ğrupta 8 rat olmak u zere 4 ğruba ayrıldı. İ lk ğrup kontrol olarak belirlendi. İ kinci ğruba 12 hafta her ğu n 2 ml/kğ dozunda NÇY ğavaj ile verildi. Ü çu ncu ğruba dilu e edilen 0.2 ml/kğ iki doz CCl4 her hafta 3 ğu n ara ile intraperitoneal olarak enjekte edildi. Do rdu ncu ğruba 2 ml/kğ dozunda NÇY 12 hafta her ğu n, ğavaj ile verilirken her hafta 3 ğu n ara ile 2 doz CCl4 uyğulandı.Kontrol ğruplarında normal karaciğ er doku yapısı ğo zlenirken; CCl4+NÇY ğrubu hepatositlerde CCl4 ğrubuna ğo re daha az yoğ unlukta makro ve mikroveziku ler yağ vakuolleri ğo ru ldu . NÇY uyğulamalarında histopatolojik değ işiklikler kısmen CCl4 ğrubuna ğo re kısmen azalırken, kaspaz 3 ve 9 aktivitesi de sınırlı sayıda azaldı. Kronik olarak CCl4 uyğulanan ğruplarda serum ALT aktivitesi ve karaciğ er MDA du zeyleri o nemli du zeyde artış ğo sterirken, NÇY uyğulamaları istatistiki o nemde etkilenmedi.Kronik CCl4 ile NÇY verilen deney ğruplarında karaciğ er hasarı u zerinde biyokimyasal veriler ve histopatolojik lezyonlar u zerine iyileştirici yo nden anlamlı bir etkisi ğo zlenmedi.

show abstract

The Effects of Pomegranate Seed Oil on Chronic Liver Damage Induced Carbon Tetrachloride in Rats and Determination of Hepatic Apoptosis and Caspase Activity

Ekebaş¹,

Atasever²,

Şentürk

et al. 2020

Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Ameliorative Effects of Pomegranate Peel Extract on Hepatotoxicity Induced by Carbon Tetrachloride in Mice

Abstract: Abstract:Pomegranate peel extracts (PPE) In conclusion, our results demonstrated that PPE through its antioxidant action efficiently improve the liver toxicity induced by CCl4.

Cited by 1 publication

References 32 publications

The Effects of Pomegranate Seed Oil on Chronic Liver Damage Induced Carbon Tetrachloride in Rats and Determination of Hepatic Apoptosis and Caspase Activity

The Effects of Pomegranate Seed Oil on Chronic Liver Damage Induced Carbon Tetrachloride in Rats and Determination of Hepatic Apoptosis and Caspase Activity

Contact Info

Product

Resources

About