Ameliorative Effects of <i>Dendropanax morbifera</i> on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in <i>β</i>-Amyloid-Induced Mice

Kim, Mi-Jeong; Park, Soo Yeon; Lee, Seung‐Hyun; Yongjae, Kim; Kim, Young Jun; Jun, Woojin; Yoon, Ho Geun

doi:10.1089/jmf.2018.4375

Cited by 6 publications

(6 citation statements)

References 38 publications

(44 reference statements)

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“…Natural compounds, such as β-Amyrin, were tested for ameliorating memory deficit and decreasing neurogenesis impairments in Aβ-injected AD mice models [106]. Similarly, Dendropanax morbifera was tested in Aβ peptide-treated mice in order to produce brain neuron damage and on cognitive deficit in neuronal cell, showing benefic effects [107] the same way Salicornia europaea L. administration demonstrated anti-neuroinflammatory and ameliorative potential in scopolamine-induced amnesic C57/BL6N mice [108]. These observations are also sustained by years of clinical expertise and observations.…”

Section: Different Preclinical Models To Study Cholinergic Hypothesismentioning

confidence: 99%

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

et al. 2019

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Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning. The etiology of this disease is not completely understood, and no safe and effective anti-Alzheimer’s disease drug to prevent, stop, or reverse its evolution is currently available. Current pharmacotherapy concentrated on drugs that aimed to improve the cerebral acetylcholine levels by facilitating cholinergic neurotransmission through inhibiting cholinesterase. These compounds, recognized as cholinesterase inhibitors, offer a viable target across key sign domains of Alzheimer’s disease, but have a modest influence on improving the progression of this condition. In this paper, we sought to highlight the current understanding of the cholinergic system involvement in Alzheimer’s disease progression in relation to the recent status of the available cholinesterase inhibitors as effective therapeutics.

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Section: Different Preclinical Models To Study Cholinergic Hypothesismentioning

confidence: 99%

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

et al. 2019

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“…Overall, TPs have beneficial effects in protecting neurons from exogenous damage, such as STS-induced neurotoxicity and cell death. Moreover, EGCG also improved memory in PS2 mice by inhibiting ERK and NF- βB pathways to induce γ-secretase and β-secretase activity [ 115 ].…”

Section: Mechanisms Of the Neuroprotective Effect Of Tpsmentioning

confidence: 99%

The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora

Zhang

et al. 2021

Molecules

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Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the “microflora–gut–brain axis”, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe–gut–brain axis) occurs through a variety of pathways, including the vagus nerve, immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and behavior, which is usually associated with neuropsychiatric disorders. In this review, we discuss that TPs and their metabolites may provide benefits by restoring the imbalance of intestinal microbiota and that TPs are metabolized by intestinal flora, to provide a new idea for TPs to play a neuroprotective role by regulating intestinal flora.

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“…In addition, rutin treatment modulated the Bax/Bcl-2 ratio, and caspase-3 activation and prevented apoptotic cell death. Finally, it was also observed that rutin effectively suppressed JNK and p38 MAPK signaling induced by rotenone [ 66 ].…”

Section: Medicinal Uses and Pharmacological Properties Of mentioning

confidence: 99%

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

Balakrishnan¹,

Cho²,

Kim³

et al. 2020

Antioxidants

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The Dendropanax genus is a kind of flowering plant in the family of Araliaceae that encompasses approximately 91 to 95 species. Several Dendropanax species are used as traditional medicinal plants, extensively used Korea and South America and other parts of the world. Almost every part of the plant, including the leaves, bark, roots, and stems, can be used as traditional medicine for the prevention and management of a broad spectrum of health disorders. This paper sought to summarizes the ethnopharmacological benefits, biological activities, and phytochemical investigations of plants from the genus Dendropanax, and perhaps to subsequently elucidate potential new perspectives for future pharmacological research to consider. Modern scientific literature suggests that plants of the Dendropanax genus, together with active compounds isolated from it, possess a wide range of therapeutic and pharmacological applications, including antifungal, anti-complement, antioxidant, antibacterial, insect antifeedant, cytotoxic, anti-inflammatory, neuroprotective, anti-diabetic, anti-cancer, and anti-hypouricemic properties. The botanical descriptions of approximately six to 10 species are provided by different scientific web sources. However, only six species, namely, D. morbiferus, D. gonatopodus, D. dentiger, D. capillaris, D. chevalieri, and D. arboreus, were included in the present investigation to undergo phytochemical evaluation, due to the unavailability of data for the remaining species. Among these plant species, a high concentration of variable bioactive ingredients was identified. In particular, D. morbifera is a traditional medicinal plant used for the multiple treatment purposes and management of several human diseases or health conditions. Previous experimental evidence supports that the D. morbifera species could be used to treat various inflammatory disorders, diarrhea, diabetes, cancer, and some microbial infections. It has recently been reported, by our group and other researchers, that D. morbifera possesses a neuroprotective and memory-enhancing agent. A total of 259 compounds have been identified among six species, with 78 sourced from five of these species reported to be bioactive. However, there is no up-to-date information concerning the D. morbifera, its different biological properties, or its prospective benefits in the enhancement of human health. In the present study, we set out to conduct a comprehensive analysis of the botany, traditional medicinal history, and medicinal resources of species of the Dendropanax genus. In addition, we explore several phytochemical constituents identified in different species of the Dendropanax genus and their biological properties. Finally, we offer comprehensive analysis findings of the phytochemistry, medicinal uses, pharmacological actions, and a toxicity and safety evaluation of the D. morbifera species and its main bioactive ingredients for future consideration.

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Ameliorative Effects of Dendropanax morbifera on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in β-Amyloid-Induced Mice

Cited by 6 publications

References 38 publications

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

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