Ameliorative effects of ginsenosides on myelosuppression induced by chemotherapy or radiotherapy

He, Mengjiao; Wang, Na; Zheng, Wenxiu; Cai, Xiaoqing; Qi, Dongmei; Zhang, Yongqing; Han, Chunchao

doi:10.1016/j.jep.2020.113581

Cited by 22 publications

(17 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On day 7 after radiotherapy, patients underwent routine blood tests. According to the WHO myelosuppression criteria [15], leukopenia was classified into grades 0 to IV, with grade 0 for leukocytes ≥4.0 × 109/L, grade I for leukocytes (3.0-3.9) × 109/L, grade II for leukocytes (2.0-2.9) × 109/L, grade III for leukocytes (1.0-1.9) × 109/L, and grade IV for leukocytes ≤1.0 × 109/L.…”

Section: Leukocytementioning

confidence: 99%

Effect of Shenqi Fuzheng Injection on Leukopenia and T-cell Subsets in Patients with Non-small Cell Lung Cancer Undergoing Radiotherapy

Liang

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Purpose. The aim of this study is to evaluate the effect of Shenqi fuzheng injection on leukopenia and T-cell subsets in patients with non-small cell lung cancer (NSCLC) undergoing radiotherapy. Methods. A total of 124 patients with advanced NSCLC treated in the oncology department of our hospital from January 2017 to January 2019 were included and assigned at a ratio of 1 : 1 to receive conventional radiotherapy (control group, n = 62) or conventional radiotherapy plus Shenqi Fuzheng injection (study group, n = 62) via the random number table method. Results. The study group showed a significantly higher objective response rate (ORR) and a lower incidence of leukopenia versus the control group ( P < 0.05 ). After the treatment, Shenqi Fuzheng injection resulted in significantly lower levels of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) in the study group versus conventional treatment given to the control group. After the treatment, the control group showed significantly decreased ratios of CD3+ T cells, CD4+ T cells, and CD4+/CD8+, and an increased ratio of CD8+ T cells, and significant differences when compared with the study group. The T-cell subsets of the patients in the study group showed no significant changes than those between the treatment. The median OS was 20.0 months in the control group and 23.5 months in the study group. The differences between the two groups in terms of OS did not come up to the statistical standard. Conclusion. Shenqi Fuzheng injection for NSCLC patients undergoing radiotherapy elevates the number of white blood cells, regulates T-cell immune function, reduces tumor markers, and enhances clinical efficacy. Further clinical trials are, however, required prior to clinical promotion.

show abstract

Section: Leukocytementioning

confidence: 99%

Effect of Shenqi Fuzheng Injection on Leukopenia and T-cell Subsets in Patients with Non-small Cell Lung Cancer Undergoing Radiotherapy

Liang

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Sinularin exhibits the selective killing of cancer cells, and it shows low cytotoxicity to several non-malignant cells [ 24 , 25 , 26 ], which may demonstrate that sinularin has a low side effect potential for normal cells. A combined treatment with natural products may alleviate radio- and chemo-resistance or side effects in cancer therapy [ 5 , 6 ]. Recently, several potential UVC sensitizers for the antiproliferation of oral cancer cells were reported [ 13 , 15 , 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The problems of radio- and chemo-resistance, and their associated side effects, may weaken their anticancer applications in oral cancer therapies [ 2 , 3 , 4 ]. Combined treatment with natural products provides an improved strategy to overcome radio- and chemo-resistance or side effects in cancer therapy [ 5 , 6 ]. For the complex etiology and targeting of cancer, combinations of anticancer drugs, natural products and radiation are increasingly used to improve the therapeutic efficiency for oral cancer [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells

Peng

Tang

et al. 2021

Cancers

View full text Add to dashboard Cite

Combined treatment is increasingly used to improve cancer therapy. Non-ionizing radiation ultraviolet-C (UVC) and sinularin, a coral Sinularia flexibilis-derived cembranolide, were separately reported to provide an antiproliferation function to some kinds of cancer cells. However, an antiproliferation function using the combined treatment of UVC/sinularin has not been investigated as yet. This study aimed to examine the combined antiproliferation function and explore the combination of UVC/sinularin in oral cancer cells compared to normal oral cells. Regarding cell viability, UVC/sinularin displays the synergistic and selective killing of two oral cancer cell lines, but remains non-effective for normal oral cell lines compared to treatments in terms of MTS and ATP assays. In tests using the flow cytometry, luminescence, and Western blotting methods, UVC/sinularin-treated oral cancer cells exhibited higher reactive oxygen species production, mitochondrial superoxide generation, mitochondrial membrane potential destruction, annexin V, pan-caspase, caspase 3/7, and cleaved-poly (ADP-ribose) polymerase expressions than that in normal oral cells. Accordingly, oxidative stress and apoptosis are highly induced in a combined UVC/sinularin treatment. Moreover, UVC/sinularin treatment provides higher G2/M arrest and γH2AX/8-hydroxyl-2′deoxyguanosine-detected DNA damages in oral cancer cells than in the separate treatments. A pretreatment can revert all of these changes of UVC/sinularin treatment with the antioxidant N-acetylcysteine. Taken together, UVC/sinularin acting upon oral cancer cells exhibits a synergistic and selective antiproliferation ability involving oxidative stress-dependent apoptosis and cellular DNA damage with low toxic side effects on normal oral cells.

show abstract

“…Myelosuppression is a significant side effect of most chemotherapeutic and radiotherapeutic agents [1], leading to decreased red and white blood cell populations [2] and potential immunosuppression [3]. Fatal infections may occur in severe cases [4].…”

Section: Introductionmentioning

confidence: 99%

The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement

Wang

Zhang

Meng

et al. 2021

Cells

View full text Add to dashboard Cite

Protein hydrolysate injection (PH) is a sterile solution of hydrolyzed protein and sorbitol that contains 17 amino acids and has a molecular mass of 185.0–622.0 g/mol. This study investigated the effect of PH on hematopoietic function in K562 cells and mice with cyclophosphamide (CTX)-induced hematopoietic dysfunction. In these myelosuppressed mice, PH increased the number of hematopoietic cells in the bone marrow (BM) and regulated the concentration of several factors related to hematopoietic function. PH restored peripheral blood cell concentrations and increased the numbers of hematopoietic stem cells and progenitor cells (HSPCs), B lymphocytes, macrophages, and granulocytes in the BM of CTX-treated mice. Moreover, PH regulated the concentrations of macrophage colony stimulating factor (M-CSF), interleukin (IL)-2, and other hematopoiesis-related cytokines in the serum, spleen, femoral condyle, and sternum. In K562 cells, the PH-induced upregulation of hematopoiesis-related proteins was inhibited by transfection with M-CSF siRNA. Therefore, PH might benefit the BM hematopoietic system via the regulation of M-CSF expression, suggesting a potential role for PH in the treatment of hematopoietic dysfunction caused by cancer therapy.

show abstract

Ameliorative effects of ginsenosides on myelosuppression induced by chemotherapy or radiotherapy

Cited by 22 publications

References 82 publications

Effect of Shenqi Fuzheng Injection on Leukopenia and T-cell Subsets in Patients with Non-small Cell Lung Cancer Undergoing Radiotherapy

Effect of Shenqi Fuzheng Injection on Leukopenia and T-cell Subsets in Patients with Non-small Cell Lung Cancer Undergoing Radiotherapy

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells

The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement

Contact Info

Product

Resources

About