Ameliorative effects of Diospyros lotus leaf extract against UVB-induced skin damage in BALB/c mice

Cho, Byoung Ok; Nchang, Denis; Shin, Jae Young; Kang, Hyun Ju; Kim, Jang Ho; Kim, Hyo Young; Cho, Wan Goo; Jang, Seon Il

doi:10.1016/j.biopha.2017.07.159

Cited by 30 publications

(24 citation statements)

References 35 publications

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“…Plants are the richest sources which included bioactive compounds. All kinds of residual product of plants have different biological activities and play a very important role for maintaining human health and treatment of disease [1][2][3][4][5]. So many plants were used as traditional Chinese Medicine and have many unexpected effects that western medicine cannot achieved [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents and medical function of leaves of Diospyros lotus L.

et al. 2020

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The potential use of leaves of Diospyros lotus L. was analyzed by using FT-IR, GC-MS and MTT through organic solvent extracts. The results showed that the leaves extracts of Diospyros lotus L. contains many kinds of bioactive organic ingredients with antibacterial, antitumor, and anti-inflammatory activities. Meanwhile the extracts have significant effect on HEGP2, SGC-7091, and K562. Therefore, it provides a scientific foundation for comprehensive application prospects in the fields of biomedicine, food, skin care products and other fields and turning waste into treasure.

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Section: Introductionmentioning

confidence: 99%

Chemical constituents and medical function of leaves of Diospyros lotus L.

et al. 2020

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“…In previous studies, plant extracts have been reported to protect against obesity-induced oxidative damage in mice (41,42). Our previous study also demonstrated that DLE protects against UVB-induced oxidative damage and acetaminophen-induced oxidative liver damage in mice (38,43). Therefore, it can be suggested that DLE may be a potent antioxidant used for preventing the oxidative stress associated with HFD-induced obesity.…”

Section: Discussionmentioning

confidence: 81%

“…HPLC analysis revealed that DLE contains myricitrin, gallic acid and astragalin. In a previous study, we reported that ethanol extracts of D. lotus leaf contained myricitrin as the main flavonoid compound (43). It has been demonstrated that plant extracts containing myricitrin exhibit anti-obesity effects in HFD-induced obese mice (4).…”

Section: Discussionmentioning

confidence: 93%

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Kim

Cho²,

Jang³

2018

Int J Mol Med

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Diospyros (D.) lotus has been demonstrated to have antioxidant and anti-inflammatory properties. The purpose of the present study was to evaluate the effect of D. lotus leaf water extract (DLE) on high-fat diet (HFD)-induced obesity in c57BL/6 mice. The present study first investigated the effect of DLE on the lipid accumulation and triglyceride (TG) contents in 3T3-L1 cells, and the results revealed that treatment with DLE suppressed the lipid accumulation and TG level. Subsequently, the anti-obesity effects of DLE were investigated in vivo. Oral administration of DLE reduced the body weight gain, food efficiency ratio, and liver and visceral fat weight in mice fed with a HFD. DLE administration in these mice also reduced TG, total cholesterol, low-density lipoprotein cholesterol, glucose, insulin and leptin levels, as well as the atherogenic index. Furthermore, DLE administration decreased hepatic steatosis, as well as serum aspartate transaminase, alanine transaminase and alkaline phosphatase levels in mice fed with HFD. It was further observed that treatment of the HFD-fed mice with DLE prevented lipid peroxidation, while it recovered glutathione depletion and the activities of superoxide dismutase, catalase and glutathione peroxidase. In conclusion, the current study suggests that the anti-obesity effect of DLE may provide positive insights as a potential functional food ingredient for the prevention of obesity.

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“…The contents of Mytr in Fr 5 and D. lotus leaves were as high as 28240.7 mg/100 g and 2107.5 mg/100 g, which was significantly higher than that of Myt, Myt-Gal, and Myt-Glc (P < 0.05). Cho et al 23…”

Section: Active Ingredients In Frmentioning

confidence: 99%

Nitrite Scavenging and Inhibition of N-Nitrosamines Formation by Phenolic Extracts From Diospyros lotus L. Leaves and Active Ingredients

Tian

Wang

et al. 2020

Natural Product Communications

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Diospyros lotus L. leaves are used as a functional tea and folk medicine in several Asian countries. This study aimed to evaluate the effects of phenolic extracts of the leaves on scavenging nitrite and inhibiting N-nitrosamines (NAs) formation and to determine the active ingredients responsible for these effects. Of the 7 fractions (Fr1-Fr7) prepared from the extract of D. lotus leaves, Fr5 contained the highest phenolic content and exhibited the strongest activity. Five active ingredients of Fr5 were discovered, and 4 of them were identified as myricitrin (Mytr), myricetin (Myt), myricetin-3- O-β-d-glucoside (Myt-Glc), and myricetin-3- O-β-d-galactoside (Myt-Gal). The content of Mytr was much higher than those of the other 3 ingredients, both in Fr5 and extracts of D. lotus leaves. Finally, Mytr and Myt were proved to have stronger activities by the 1,1-diphenyl-2-trinitrophenyl hydrazine scavenging, nitrite scavenging, and inhibition of NAs formation assays. These results indicated that Mytr was the main active ingredient of D. lotus leaves. Myt, Mytr, and Fr5 from the leaves could be used as natural agents for antioxidant, nitrite scavenging, and inhibition of NAs formation in food and the human body.

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Ameliorative effects of Diospyros lotus leaf extract against UVB-induced skin damage in BALB/c mice

Cited by 30 publications

References 35 publications

Chemical constituents and medical function of leaves of Diospyros lotus L.

Chemical constituents and medical function of leaves of Diospyros lotus L.

Anti-obesity effects of Diospyros�lotus leaf extract in mice with high-fat diet-induced obesity

Nitrite Scavenging and Inhibition of N-Nitrosamines Formation by Phenolic Extracts From Diospyros lotus L. Leaves and Active Ingredients

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