Ameliorative Effects of Component Chinese Medicine From Curcumae Rhizoma and Sparganii Rhizoma, a Traditional Herb Pair, on Uterine Leiomyoma in a Rat Model

Abstract

Uterine leiomyoma (UL), common benign tumors in women of child-bearing age, are believed to be caused mainly by Qi stagnation and blood stasis, according to a theory of traditional Chinese medicine. Curcumae Rhizoma and Sparganii Rhizoma (CRSR) is a classical herb pair that activates blood circulation to dissipate blood stasis. The purpose of this study was to explore the prevention and treatment effects of CRSR component compatibility on UL in rats. We randomly assigned adult female non-pregnant rats into three groups: a normal control (NC) group, a UL model group, and a CRSR treatment group. We administered to the UL and CRSR groups oral gavage diethylstilbestrol and injected them with progesterone (P) to establish UL for 5 weeks. The CRSR group received a CRSR medicinal solution after daily modeling. The uterus morphology of the UL group showed significantly more swelling than did that of the NC group, and we found no significant abnormalities in the morphology of the CRSR group. The pathological changes associated with UL were relieved in the CRSR group. CRSR improved the related parameters of the uterus and ovarian coefficients, significantly reducing the concentrations of P in the serum and the concentrations of estradiol, P, estrogen receptor, and P receptor in the uterus and ovary. In addition, CRSR significantly improved the abnormal blood conditions of UL, shown by decreases in plasma viscosity, the erythrocyte sedimentation rate equation K value, and erythrocyte aggregation index. Therefore, CRSR component compatibility may prevent and cure UL through the above ways.

Effects of Yishentongluo Recipe on Nrf2 and HO-1 pathway activation leading to reduction of oxidative stress and kidney fibrosis in membranous nephropathy rat model

“…These studies partly revealed the scientificity of the effects of Hirudo on alleviating blood stasis from the perspective of both chemical compound and potential mechanism. Similarly, the effects of Curcumae rhizoma on alleviate blood stasis also been reported by previous research, which may be partly related to its activities on decreasing in plasma viscosity, erythrocyte aggregation index as well as the erythrocyte sedimentation rate equation K value (Zhang et al, 2021). These above-mentioned researches provided some evidence support of the efficacies of Pheretima, Hirudo, and Curcumae rhizoma on promoting blood circulation and alleviating blood stasis.…”

Identification and Validation of miRNA-TF-mRNA Regulatory Networks in Uterine Fibroids

“…The cumulative incidence of UF in women before the age of 50 is as high as 70% ( Walker and Stewart, 2005 ). Despite their benign nature, UF still causes a variety of symptoms, such as pelvic pressure, uterine bleeding, anemia, or infertility ( Islam et al, 2013 ), and is mainly treated through surgery and drugs ( Zhang L. et al, 2021 ), such as hysterectomy, leading to devastating effects on approximately two 200,000 per year in United States ( Cardozo et al, 2012 ). Unfortunately, their origins and internal mechanism have not been characterized so far ( Andersen and Barbieri, 1995 ).…”

Potential mechanism of Taohong Siwu Decoction in uterine fibroid treatment based on integrated strategy of network pharmacology and experimental verification

“…The wet weight of the uterus and ovary and the uterine and ovarian coefficients were determined. The organ coefficient was calculated as the wet organ weight/body weight of rats (when sampling) × 100% [ 15 ].…”