Ameliorative effects of aqueous seed-extract of Dacryodes edulis on doxorubicin-induced cardiac tissue damage in albino rats

Abstract

Ameliorative effects of aqueous seed extract of D acryodes edulis on doxorubicininduced cardiac tissue damage in albino rats were investigated. The animals were divided into groups and fed for 14 days to acclimatize. A single dose of 15 mg/kg body weight doxorubicin was given intraperitoneally to each group except the control group. After 48 hours, two animals were randomly selected from each group and sacrificed under ethylether anesthesia, to harvest their hearts for histological studies. Subsequently, groups 1 and 2 were given normal saline, while groups 3 and 4 were treated with 25 and 100 mg/kg body weight of aspirin and vitamin C respectively. Groups 5-8 received different doses of aqueous seed extract (200, 400, 600, and 800 mg/kg body weight). Treatments lasted for 21 days and the rats were sacrificed under anesthesia, and their hearts harvested and fixed in 10% formol saline for examination. The photomicrograph revealed severe and focal loss of cardiac fiber, intra-myocardial hemorrhages, fragmentation of cardiac muscle, and disorganization of histoarchitecture in the induced but untreated animal groups. Micrographs showed significant ameliorative effects of the extract in a dose-dependent way and healing effects of the standard drugs. These results showed that aqueous seed extract of Dacryodes edulis exhibits therapeutic potentials for cardiac disorders.

High Doses of Ketamine Inflict Myocardial Injury and Cause Changes in the Relative Body Weight to Heart of Adult Albino Wistar Rats

“…There is a oneway flow through the heart; and this flow is maintained by a set of four valves: the atrioventricular valves (tricuspid and bicuspid) allow blood to flow from atria to ventricle and the semilunar valves (pulmonary and semilunar) allow blood flow only from the ventricles out of the heart and through the great vessels. Due to the numerous functions of the heart, the heart is the highest energy-consuming organ of the body, and subtle energetic deficits or induction agents can rapidly induce contractile dysfunction [13].…”

“…Cardiac-related disorders rank high among the major public health concern ailments and their prevalence is increasing at a geometrical rate, especially in developing countries like Nigeria [13]. Commonly used induction and maintenance anesthesia protocols involve agents that are known to affect the sympathetic and parasympathetic nervous systems, vascular tone, and contractile properties of the myocardium [16].…”