Ameliorative effects of Anchomanes difformis aqueous extract against oxidative stress in the testes and epididymis of streptozotocin-induced diabetic male Wistar rats

Nethengwe, Murendeni; Okaiyeto, Kunle; Oguntibeju, Oluwafemi Omoniyi; Brooks, Nicole L

doi:10.1016/j.sjbs.2022.03.015

Cited by 2 publications

(3 citation statements)

References 50 publications

(91 reference statements)

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“…The observed ameliorative impact of either treatment was associated with parallel retractions in the oxidative tissue contents, MDA/antioxidants, GSH concentration, and CAT activity, confirming their suppressive impact on oxidative injury. Indeed, oxidative injury has repeatedly been reported to be a major contributor to DM-induced complications [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

El-Sherbiny

El-Shafey

Said

et al. 2022

Life

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In this study, we aim to explore the beneficial therapeutic impacts of dapagliflozin (Dapa), a highly potent, reversible, and selective sodium–glucose cotransporter-2 inhibitor, and liraglutide (Lira), a glucagon-like peptide-1 (GLP-1) receptor agonist, as hypoglycaemic agents for the management of diabetes mellitus (DM), as well as their combination against DM-induced complications, including hepato-renal injury. Indeed, the progression of DM was found to be associated with significant hepatic and renal injury, as confirmed by the elevated biochemical indices of hepatic and renal functions, as well as histopathological examination. Dapa, Lira, and their combination effectively attenuated DM-induced hepatic and renal injury, as confirmed by the recovery of hepatic and renal functional biomarkers. The administration of both drugs significantly reduced the tissue contents of MDA and restored the contents of GSH and catalase activity. Moreover, NF-κB and TNF-α expression at the protein and gene levels was significantly reduced in the liver and the kidney. This was in parallel with the significant reduction in the caspase-3 content in the liver and the kidney, as well as suppressed cleaved caspase-3 expression in the hepatic and renal specimens, as confirmed by immune–histochemical analysis. Notably, the combined Dapa/Lira treatment demonstrated an additive superior hepato-renal protective impact compared with the use of either drug alone. Thus, it appears that Dapa and Lira, through the coordinated modulation of oxidative, inflammatory, and apoptotic signalling, confer a significant hepato-renal protective impact against DM-induced complications and tissue injury.

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Section: Discussionmentioning

confidence: 99%

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

El-Sherbiny

El-Shafey

Said

et al. 2022

Life

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“…[4] Therefore, there was an urgent need for treatments to regulate blood glucose level (BGL). [5] The synthetic chemical drugs have many drawbacks therefore the usage of antidiabetic substances related to natural products become very required. [6] Streptozotocin (STZ) is hydrophilic, cytotoxic analogue of glucose that enters β-cells through glucose transport 2 (GLUT2).…”

Section: Introductionmentioning

confidence: 99%

“…In 2021, the number of diabetic populations was 536.6 million, by 2030 it is predicted to be 643 million, also by 2045, the predicted number will be reached to 783 million [4] . Therefore, there was an urgent need for treatments to regulate blood glucose level (BGL) [5] . The synthetic chemical drugs have many drawbacks therefore the usage of antidiabetic substances related to natural products become very required [6] …”

Section: Introductionmentioning

confidence: 99%

Regulation of Oxidative Stress and Apoptosis in Streptozotocin‐Induced Diabetic Rats by Egyptian Sidr Honey

El‐Aarag,

Shehata,

El‐Garawani

et al. 2024

Chemistry & Biodiversity

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Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over time to severe damage to numerous tissues. The present study aimed to estimate the effect of Egyptian Sidr honey against streptozotocin‐induced diabetes in rats. Diabetic rats were treated with Sidr honey daily for 4 consecutive weeks. The biochemical profile of blood samples was measured. Furthermore, the activity of antioxidant enzymes, nitric oxide (NO), and malonaldehyde (MDA) were examined in liver and pancreas tissues. Moreover, the expression of Bax, Caspase‐3, and Bcl2 proteins were measured. Results revealed that the capability of Sidr honey to decline the elevated blood glucose and fructosamine levels compared to diabetic rats. Also, the honey decreased the levels of NO and MDA. Furthermore, it regulated the antioxidant enzymes activity. Moreover, it reduced the expression levels of Caspase‐3 and Bax while increased the Bcl2 level. In conclusion, Sidr honey can regulate hyperglycemia, oxidative stress, apoptosis, and antioxidant enzymes in STZ‐induced diabetic rats.

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Ameliorative effects of Anchomanes difformis aqueous extract against oxidative stress in the testes and epididymis of streptozotocin-induced diabetic male Wistar rats

Cited by 2 publications

References 50 publications

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation

Regulation of Oxidative Stress and Apoptosis in Streptozotocin‐Induced Diabetic Rats by Egyptian Sidr Honey

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