Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. bark in Animal Models of Inflammation and Arthritis

Rathi, Badal

doi:10.3797/scipharm.1301-16

Cited by 49 publications

(37 citation statements)

References 64 publications

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“…Cinnamon bark ( Cinnamomum zeylanicum ), one of the most common spices used in Indian, Bangladeshi, Burmese, and Sri Lankan dishes, can confer some protective effects against RA. Rathi et al [ 189 ] observed a significantly ( p < 0.001) higher level of anti-inflammatory activities [inhibition of cytokines (IL-2, IL-4, and IFN- γ ) and reduction of TNF- α concentration] upon the treatment of RA animal models (male Wistar rat and Swiss albino mice) with the polyphenolic fractions of cinnamon bark.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation‐Mediated Degenerative Diseases

Islam

Alam

Solayman

et al. 2016

Oxidative Medicine and Cellular Longevity

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Cumulatively, degenerative disease is one of the most fatal groups of diseases, and it contributes to the mortality and poor quality of life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellitus (DM), and cardiovascular disease (CVD). Although a number of synthetic medications are used to treat these diseases, none of the current regimens are completely safe. Phytochemicals (polyphenols, carotenoids, anthocyanins, alkaloids, glycosides, saponins, and terpenes) from natural products such as dietary fruits, vegetables, and spices are potential sources of alternative medications to attenuate the oxidative stress and inflammation associated with degenerative diseases. Based on in vitro, in vivo, and clinical trials, some of these active compounds have shown good promise for development into novel agents for treating RA, DM, and CVD by targeting oxidative stress and inflammation. In this review, phytochemicals from natural products with the potential of ameliorating degenerative disease involving the bone, metabolism, and the heart are described.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation‐Mediated Degenerative Diseases

Islam

Alam

Solayman

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…[14] Since ages, the importance of several medicinal plants has been mentioned in the treatment of diabetes. One such plant is Cinnamomum zeylanicum (family-Lauraceae), has shown numerous pharmacological properties, such as anti-inflammatory, [15] antiarthritic, [16] antimicrobial, [17] and antioxidant [18] activities. In vitro and in vivo antidiabetic studies on C. zeylanicum bark have shown to promote insulin receptor phosphorylation, insulin signaling, and enhancing IS.…”

Section: Original Articlementioning

confidence: 99%

Untitled

M.N¹

2019

IJGP

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Introduction: Evidence(s) established that high fructose (HFr) diet may be responsible for the development of insulin resistance (IR). The aim is to appraise the ameliorative effects of Cinnamomum zeylanicum bark extracts on adiposity, insulin sensitivity (IS) and cardiometabolic markers in HFr diet-induced IR. Materials and Methods: A total of 30 Wistar male albino rats (240-300 g) were divided into five groups (n = 6) and had free access to both diet and water. Groups I and II served as normal control and HFr control (HFrC), received gum acacia (2%) and fructose (60% w/v) diet. Groups III-V were orally administered pioglitazone (PGZ 50 mg/kg/b.wt), aqueous (Cinnamon bark aqueous extract [CBAE] 1 g/kg/b.wt), and ethanolic (Cinnamon bark ethanolic extract [CBEE] 1 g/kg/b.wt) extracts of cinnamon bark, respectively, from day 28 onwards till end of the study. All the groups, except normal control received HFr diet for 42 days. At the end weight gain, adiposity, adiponectin, and cardiometabolic markers (C-reactive protein and uric acid), and cardiovascular (CV) risks, IR and IS indices were evaluated. Results: HFr feeding significantly increased weight gain, adiposity and decreased adiponectin levels along with increased cardiometabolic markers as compared to normal control. HFrC significantly increased the CV and decreased IS indices as compared to normal control. PGZ, CBAE, and CBEE groups significantly reduced adiposity, and both cinnamon groups had decreased the weight gain as compared to HFrC. PGZ and CBAE significantly increased adiponectin levels, whereas cinnamon groups and PGZ had decreased cardiometabolic markers as compared to HFrC. Similarly, PGZ and cinnamon extracts had improved IS as compared to HFrC. Conclusion: The study concluded that cinnamon extracts had exhibited insulin-sensitizing effects in IR and associated metabolic risk factors by modulating adiponectin in HFr fed rats. Therefore, the study proposes to use cinnamon as a functional food supplement in the management of diabetes and obesity.

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“…[51] In another study, C. zeylenicum extract was found to reduce inflammation and arthritis in rats by suppressing intracellular release of TNF-α in dose-dependent manner and; hence is an effective remedy for treating RA. [52,53] …”

Section: Guggulosteronementioning

confidence: 99%

Untitled

2017

IJGP

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Rheumatoid arthritis (RA) is a chronic, progressive, sustained inflammatory autoimmune disease associated with articular, extraarticular, and systemic effects. It is characterized by synovial inflammation, hyperplasia, leading to destruction of articular cartilage, bone erosion, and ultimately permanent deformities. Conventional treatments for RA include non-steroidal anti-inflammatory drugs, disease modifying antirheumatoid drugs, corticosteroids, and biological agents. All these therapeutic agents are associated with one or more side-effects, and none of the available treatments are able to achieve the ultimate therapeutic goal, i.e., drug-free remission. Herbal remedies are alternative source to relieve symptoms in patients having RA as well as to overcome the drawbacks associated with present treatment methods. A study conducted by the World Health Organization had reported that about 80% of world's population relies on traditional medicine. More than 450 plants belonging to 100 families are used traditionally in management of arthritis. Some of the important natural compounds reported toexhibit anti-arthritic potential includes anthroquinone (Aloe barbadensis), with anolides (Withania somnifera), terpenes (Zingiber officinale, Boswellia serrata), polyphenols (Camellia sinensis), stilbene (Vitis vinifera, Tripterygium wilfordi). Although a number of herbal medicines are recommended for RA, further research is required to investigate their safety, efficacy, and potential drug interactions.

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Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. bark in Animal Models of Inflammation and Arthritis

Cited by 49 publications

References 64 publications

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation‐Mediated Degenerative Diseases

Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation‐Mediated Degenerative Diseases

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