Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment

Awadalla, Eatemad A.

doi:10.1016/j.bionut.2012.08.005

Cited by 27 publications

(29 citation statements)

References 37 publications

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“…Lead is known to induce malfunctioning of the reproductive organs by directly affecting its morphological structure, thereby also causing decreased sperm quality [30,31]. The ameliorative effects of NS against several toxic compounds have been reported in literature [10,13-15,32]. Al-Masri [33] had reported that LA caused significant decreases in sperm motility, count and viability of sperm, while there was in an increase in sperm abnormality.…”

Section: Discussionmentioning

confidence: 99%

“…Both the seed and oil of NS have been shown to exhibit different therapeutic properties which include antiparasitic, antifungal, anticancer, antimicrobial, anti-inflammatory, and effects against toxicity [8,9]. The ameliorative effects of NS against sodium valproate [10], heat stress [11], LA [12], isoproterenol [13], tramadol [14], and cisplatin toxicity [15] have been reported in literature.…”

Section: Introductionmentioning

confidence: 99%

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Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats

et al. 2016

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Aim:This study was designed to evaluate the prophylactic effect of Nigella sativa (NS) treatment on toxic effects induced by lead acetate (LA) on the reproductive hormones, spermiogram and gonadal histology of rats.Materials and Methods:A total of 20 Sprague-Dawley rats were divided into four groups of five rats each. Group 1 (negative control [NC]) was the NC and was given distilled water, Group 2 served as the positive control (PC) and was administered 10 mg/kg/day of LA per overall survival (OS), Group 3 (T1) was administered 200 mg/kg/daily of NS per OS for a month, and Group 4 (T2) was pretreated with 200 mg/kg/daily of NS per OS for 1 month, followed by 10 mg/kg/daily of LA alone per OS for another. The rats were euthanized at the end of the experimental period for collection of blood and the right caudal epididymis and testis. Serum was used for determination of reproductive hormones by using radioimmunoassay kits. The epididymal segment was cut and homogenized in phosphate-buffered saline, and the homogenate was used for determination of the spermiogram parameters such as sperm concentration, sperm viability, percentage of live sperm, motility and abnormality. Both the epididymis and testis were fixed in 10% buffered formalin for histological processing.Results:The sperm concentration, general, and individual motilities were higher (p<0.05) in the NC and T1 animals, while the T2 had intermediate and the PC had lower (p<0.05) values of each parameter. The percentage sperm viability was higher (p<0.05) in the T1 and lower (p<0.05) in the PC group. However, percentage abnormality was lower in T1, comparable in NC and T2, and higher (p<0.05) in PC. Spermatogenic cell population and epididymal sperm reserve (ESR) were optimal in control and pretreated animals, while the PC had lower spermatids and ESR. The concentration of estradiol (EST) was lower (p<0.05) in the PC and T2, while leuteinizing hormone (LH) concentration was lower (p<0.05) in the PC, and comparable (p>0.05) between control and T2. The concentration of follicle-stimulating hormone (FSH) was comparable (p>0.05) in all groups, while testosterone (TS) hormone concentration was lower (p<0.05) in the PC and higher in the control and T1 groups.Conclusion:This study showed the preventive effects of NS administration against alterations in reproductive hormnes, sperm parameters and gonadal histology caused by LA in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats

et al. 2016

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“…This dose was given orally by gastric intubation daily for 30 day. The chosen dose of Nigella sativa oil (NSO) extract was 0.5 ml/kg b.wt (Awadalla, 2012). This dose was given orally by gastric intubation daily for 30 days.…”

Section: Doses and Treatmentmentioning

confidence: 99%

“…Group (2): administered sodium valproate (VPA) orally at dose of (500 mg/kg b.wt) (Niaraki et al, 2013) daily for 30 days. Group (3): administered Nigella sativa oil (NSO) extract was given orally at dose of (0.5 ml/kg b.wt) (Awadalla, 2012) daily for 30 days. Group (4): rats of this group were administered sodium valproate (VPA) orally at dose of (500 mg/kg b.wt) (Niaraki et al, 2013) daily for 30 days, then treated with Nigella sativa oil (NSO) extract was given orally at dose of (0.5 ml/kg b.wt) (Awadalla, 2012) daily for 30 days.…”

Section: Experimental Designmentioning

confidence: 99%

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

Safwat

Hussein

Samy

2017

IJB

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Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa oil (NSO) extract on the neurotoxic and hepatotoxic potentials from valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study's case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the enzymatic antioxidant, brain and liver catalase (CAT) activity and the non-enzymatic antioxidant, brain and liver glutathione (GSH) and lipid peroxidation (LPO) concentrations.

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“…Besides, antibacterial and anti-inflammatory properties of honey prevents delay in wound healing process 7 . Nigella sativa (N. sativa), an annual flowering plant native to the South and Southeast Asia has been found to have antioxidative, anti-inflammatory, antibacterial and wound healing properties [8][9][10][11][12] . However, toxicity has been reported with chronic and large surface area use of N. sativa 13,14 .…”

Section: ■ Introductionmentioning

confidence: 99%

Synergistic effect of honey and Nigella sativa on wound healing in rats

et al. 2018

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1 AbstractPurpose: To investigate the therapeutic potential of honey, Nigella sativa (N. sativa) and their combination in rat model of excisional wound healing. Methods: A circular excision wound was established in the back region of 50 Wistar rats. Subsequently, they were divided into 5 groups and daily topical administration of lanolin in the control group, honey in the honey group, cold-pressed N. sativa seed oil in the N. sativa groups, mix of 1:1 ratio of honey and N. sativa seed oil in the mix group, and phenytoin cream in the phenytoin group were used. Then, wound surface areas were evaluated using digital camera immediately after the injury and at post excision days 5, 10, 15 and 20. Results: Significant reduction in wound surface area was observed within and between the groups (P < 0.001). In the post excision days 5, 10, 15 and 20 the wound surface areas in the mix group were significantly lower than the other groups followed by the phenytoin, honey, N. sativa, and control groups. Conclusion:The wound healing may be improved and accelerated by using topical solutions of honey, N. sativa seed oil and especially their mixture.

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Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment

Cited by 27 publications

References 37 publications

Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats

Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

Synergistic effect of honey and Nigella sativa on wound healing in rats

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