Ameliorative effect of Parinari curatellifolia seed extracts on sodium nitroprusside–induced cardiovascular toxicity in rats

Much emphasis has been placed on the biological activities of citrus peel's essential oils (CPEOs) against human ailments. This study investigated the effect of Citrus limon and Citrus reticulata peel's essential oils (EOs) on behavioral and neurochemical imbalance in transgenic and Harwish (Wild) fruit flies. Flies were divided into seven groups comprising of the control and those that were fed with 0.1, 0.5, and 1.0 µg/ ml of the dietary inclusions of study CPEOs for 7 days. Thereafter, behavioral profile was examined using lethality response and negative geotaxis assays. Effect of the EOs on cholinesterase and monoamine oxidase (MAO) activities, and antioxidative parameters were determined. The result showed a significant improvement of behavioral pattern and biochemical parameters of the flies fed with studied CPEOs inclusive diets. Conclusively, both EOs exert neuroprotective capability by reducing cholinesterases and monoamine activities, and also prevent oxidative stress, which are implicated in neuronal dysfunction in humans. Practical applications With the growing increase in the search for safer alternatives, having no side effects, for the management of neurodegenerative diseases, a large proportion of the populace is beginning to find solace in the use of natural products. Also, the wide array of similarities between the humans and the dipteran insects, fruit flies is a perfect organism for the study of neurodegenerative diseases. Therefore, this study presents the neuroprotective potentials of lemon and tangerine peels-derived EOs, and the possibility of their exploration as neuroactive agents and alternative in the management of Alzheimer's disease (AD).

show abstract

Section: Biochemical Assaysmentioning

confidence: 99%

“…Thiobarbituric reactive acid species (TBARS) level was carried out according to the report of Ohkawa et al (1979) as described by Josiah et al (2020), which involved tissue (50 µl) homogenate, 8.1% of sodium dodecyl sulfate (150 µl), and HCL/acetic acid (pH 3.4) solution. The mixture was incubated at 100°C for 1 hr.…”

Section: Biochemical Assaysmentioning

confidence: 99%

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, several side effects, including unchecked upregulation of rennin angiotensin system (RAS), angiotensin‐I enzyme (ACE) activity, and angiotensin‐1 receptor, reduce endothelia nitric oxide synthase (eNOS) activity and oxidative stress via increase production of radical species; the factors that are largely responsible for hypertension (Agunloye et al., 2019; Jabir et al., 2017; Oboh et al., 2016), erectile dysfunction (Adefegha, Oyeleye, Dada, Olasehinde, & Oboh, 2018; Ademiluyi, Oyeleye, Ogunsuyi, & Oboh, 2019), cognitive impairment (Tota et al., 2012), nephrotoxicity (Bekpinar et al., 2019), among others, have been reported. Interestingly, consumption of phenolic‐rich foods/plants have been reported to have good advantages toward the alleviation of these side effects and in the management of hypertension and cardiotoxicity (Agunloye et al., 2019; Bekpinar et al., 2019; Bingul, Olgac, Bekpinar, & Uysal, 2019; Josiah, Oyeleye, Crown, & Olaleye, 2020).…”

Section: Introductionmentioning

confidence: 99%

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

et al. 2020

View full text Add to dashboard Cite

We investigated the effect of extracts from the leaf (ALE) and stem bark (ABE) of Almond tree on activities of some crucial enzymes [angiotensin-1 converting enzyme (ACE), arginase, acetylcholinesterase (AChE), phosphodiesterase-5 (PDE-5), adenosine deaminase (ADA), superoxide dismutase (SOD), catalase], and thiobarbituric acid reactive species (TBARS) associated with hypertension in normal adult male Wistar albino rats and Cyclosporine A (CsA)-stressed rats. The result revealed that CsAstressed rats treated with captopril and extracts (ALE and ABE) had lowered ACE, arginase, AChE, PDE-5, ADA activities, and TBARS level, coupled with improved SOD and catalase activities compared with untreated CsA-stressed rats, which had reversed these biochemicals compared to normal rats. This suggests that the extracts could be explored to suppress hypertension and other cardiac injury known with CsA treatment; the potentials that could be linked with the constituent polyphenols. However, further studies including blood pressure should be determined to ascertain this claim. Practical applications Drug-induced cardiotoxicity, hypertension, and organ damage are among the most common side effects of pharmaceutics. Therefore, it becomes imperative to find natural, effective, and alternative therapy with little or no side effect to combat drug toxicity. The use of Almond (leaf and stem bark) in folklore for the treatment/management of hypertension and other heart-related diseases without full scientific basis is on the increase. Hence, this study provides some biochemical evidences on the effect of Almond leaf and stem back extracts on crucial enzymes and oxidative stress markers involve in the incidence of hypertension in the course of Cyclosporine A administration. The findings of this study indicated that the studied plant materials could be promoted as nutraceutical agents to neutralize drug-induced cardiac injury and hypertension.

show abstract

“…The effects of MHT on organ function markers and other biochemical indices suggest that it is without adverse effects in normal rats, and pharmacologically effective and without adverse side effects in hyperlipidemic rats with compromised cardiac, hepatic, and renal functions. Increased serum levels of creatinine, uric acid, and urea in triton‐toxified rats revealed renal damage (El‐Demerdash & Nasr, 2014; Josiah et al, 2019; Vinod et al, 2018). Like MHT, several plant and plant‐derived foods have been reported to afford protection against kidney damage (El‐Demerdash & Nasr, 2014; Yaribeygi, Simental‐Mendía, Butler, & Sahebkar, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore important to subject medicinal plants and naturally occurring bioactive compounds from medicinal plants to scientific investigations and validation. A large number of them remain unexplored for pharmacological potential which accounts for the scanty information that supports their folkloric use (Josiah, Oyeleye, Crown, & Olaleye, 2019). In addition, the increasing preponderance of phytopharmaceuticals and nutraceuticals with touted superlative heath benefits in the absence of stringent regulations that are in place for synthetic drugs calls for scientific scrutiny to safeguard public health.…”

Section: Introductionmentioning

confidence: 99%

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

et al. 2020

View full text Add to dashboard Cite

This study investigated the safety and therapeutic effect of a multiherbal tea (MHT) on Triton X-1339-induced hyperlipidemia and associated biochemical and tissue dysfunctions. An infusion of the MHT was assessed for phytoconstituents, proximate and mineral composition, and antioxidant activity. Wistar rats administered 200 mg/ kg Triton X-1399 were post-treated with MHT for 14 days followed by biochemical estimations in serum, heart, liver, and kidney of animals. Hematological and histopathological evaluations of the blood, and liver, respectively, were also performed. Different phytochemicals were detected in MHT, toxic metals were absent and antioxidant activity was appreciable. Disturbances in glucose level and redox homeostasis, alterations in liver, kidney, and heart function markers, and imbalances in hematological parameters precipitated by triton toxicity were mitigated by posttreatment with MHT. Multiherbal tea also ameliorated triton-induced hepatic histoarchitectural abnormalities. These results suggest that MHT is apparently an effective antilipemic tea with minimal or no side effects. Practical applications Hyperlipidemia is one of the core risk factors for arteriosclerosis and a major contributor to other adverse health conditions. The prevalence of hyperlipidemia has increased drastically in the last few decades. Plant and plant products have been extensively used in the management of dyslipidemia and many plant-based antilipemic products with poorly defined toxicity and pharmacological profiles abound in the market. The results of this study demonstrated the protective effects of a MHT against triton-induced hyperlipidemia, atherogenic tendency, and dysfunction of key organs in rats and lent credence to its therapeutic relevance in the management of hyperlipidemia and related diseases. K E Y W O R D S antilipemic, hyperlipidemia, multiherbal tea, multi-organ protection, oxidative stress 1999) radicals scavenging activities as well as cupric ion (Cu 2+) reducing capacity (Apak, Güçlü, Ozyürek, & Karademir, 2004). 2.4 | Determination of proximate and mineral composition of MHT The proximate and mineral compositions of MHT were determined following previously established protocols (Horwitz & Latimer, 2005). 2.5 | In vivo evaluation of MHT in Triton-induced hyperlipidemia 2.5.1 | Animal grouping and treatment Male Wistar rats weighing 180 ± 20 g were obtained from the

show abstract

Ameliorative effect of Parinari curatellifolia seed extracts on sodium nitroprusside–induced cardiovascular toxicity in rats

Cited by 9 publications

References 30 publications

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

Extracts from Almond ( Terminalia catappa ) leaf and stem bark mitigate the activities of crucial enzymes and oxidative stress associated with hypertension in cyclosporine A‐stressed rats

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

Contact Info

Product

Resources

About