Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats

Elshazly, Shimaa M.

doi:10.1016/j.ejphar.2014.12.017

Cited by 30 publications

(27 citation statements)

References 57 publications

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“…Our results were in accordance with previous studies that chronic HFD administration in rats would cause vacuolization and infiltration of inflammatory cells in the liver 28, 29. It was found that CARD9 resulted in pathological immune cell activation, causing inflammatory or other diseases 30.…”

Section: Discussionsupporting

confidence: 93%

The essential function of CARD9 in diet‐induced inflammation and metabolic disorders in mice

Zeng

Zhang

et al. 2018

J Cellular Molecular Medi

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Inflammation and metabolic disorder are common pathophysiological conditions, which play a vital role in the development of obesity and type 2 diabetes. The purpose of this study was to explore the effects of caspase recruitment domain (CARD) 9 in the high fat diet (HFD)‐treated mice and attempt to find a molecular therapeutic target for obesity development and treatment. Sixteen male CARD9−/− and corresponding male WT mice were fed with normal diet or high fat diet, respectively, for 12 weeks. Glucose tolerance, insulin resistance, oxygen consumption and heat production of the mice were detected. The CARD9/MAPK pathway‐related gene and protein were determined in insulin‐responsive organs using Western blotting and quantitative PCR. The results showed that HFD‐induced insulin resistance and impairment of glucose tolerance were more severe in WT mice than that in the CARD9−/− mice. CARD9 absence significantly modified O2 consumption, CO 2 production and heat production. CARD9−/− mice displayed the lower expression of p38 MAPK, JNK and ERK when compared to the WT mice in both HFD‐ and ND‐treated groups. HFD induced the increase of p38 MAPK, JNK and ERK in WT mice but not in the CARD9−/− mice. The results indicated that CARD9 absence could be a vital protective factor in diet‐induced obesity via the CARD9/MAPK pathway, which may provide new insights into the development of gene knockout to improving diet‐induced obesity and metabolism disorder.

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Section: Discussionsupporting

confidence: 93%

The essential function of CARD9 in diet‐induced inflammation and metabolic disorders in mice

Zeng

Zhang

et al. 2018

J Cellular Molecular Medi

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“…In the development of NAFLD, lipid accumulation in the liver can be traced by increased free fatty acid uptake and de novo lipogenesis for increased TG synthesis, as well as impaired fatty acid beta oxidation [ 24 ]. In particular, elevated serum levels of TG lead to intrahepatic lipid accumulation [ 25 , 26 ], as well as increased LDL-C and decreased HDL-C levels in OVX animals [ 21 ]. In the present study, the OVX group displayed elevated TC, LDL-C, and TG levels and reduced HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice

Hur

Jeong

Lee

et al. 2020

Life

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Nonalcoholic fatty liver disease (NAFLD) is associated with progressive metabolic diseases. Estrogen deficiency increases the NAFLD risk among postmenopausal women. Thus, effective agents to prevent and treat NAFLD in postmenopausal women are required. Quercitrin (Quer) is a natural glycosylated flavonoid with antimicrobial, anti-inflammatory, and hypolipidemic effects. This study investigated whether Quer improves dysregulated lipid metabolism and suppresses hepatic steatosis in ovariectomized (OVX) mice as an experimental model mimicking postmenopausal women. Mice were assigned to the following four groups: SHAM, OVX, OVX + β-estradiol (0.4 mg/kg diet), and OVX + Quer (500 mg/kg diet). Mice were administered a diet with or without Quer for three months. OVX mice displayed significantly higher body mass, epidermal fat, and liver weights than those of SHAM mice. However, these levels were reduced in Quer-treated mice. Quer treatment reduced the levels of serum lipid metabolites, including triglycerides, total cholesterol, and low-density lipoprotein cholesterol. Furthermore, Quer reduced liver lipid steatosis and inhibited the expression of proinflammatory cytokines, such as tumor necrosis factor-α, IL-6, and IL-1β. The results of the present study indicate that Quer improves dysregulated lipid metabolism and reduces hepatic steatosis and inflammation by compensating for estrogen deficiency, suggesting that Quer may potentially exert protective effects during hepatic steatosis in postmenopausal women.

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“…Most patients with NAFLD have one or more risk factors, including hypertension, insulin resistance, obesity, and abnormalities in lipid metabolism, including elevated LDL-C and reduced HDL-C, which may be factors related to NASH development [ 24 ]. Circulating serum TG and FFA are stored in adipose tissue and liver [ 25 , 26 , 27 ]. The current findings showed that OVX mice experienced a marked increase in TG and LDL-C and a reduction in HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

Honokiol Improves Liver Steatosis in Ovariectomized Mice

et al. 2018

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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, and is associated with the development of metabolic syndrome. Postmenopausal women with estrogen deficiency are at a higher risk of progression to NAFLD. Estrogen has a protective effect against the progression of the disease. Currently, there are no safe and effective treatments for these liver diseases in postmenopausal women. Honokiol (Ho), a bioactive natural product derived from Magnolia spp, has anti-inflammatory, anti-angiogenic, and anti-oxidative properties. In our study, we investigated the beneficial effects of Ho on NAFLD in ovariectomized (OVX) mice. We divided the mice into four groups, as follows: SHAM, OVX, OVX+β-estradiol (0.4 mg/kg of bodyweight), and OVX+Ho (50 mg/kg of diet). Mice were fed diets with/without Ho for 12 weeks. The bodyweight, epidermal fat, and weights of liver tissue were lower in the OVX group than in the other groups. Ho improved hepatic steatosis and reduced proinflammatory cytokine levels. Moreover, Ho markedly downregulated plasma lipid levels. Our results indicate that Ho ameliorated OVX-induced fatty liver and inflammation, as well as associated lipid metabolism. These findings suggest that Ho may be hepatoprotective against NAFLD in postmenopausal women.

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Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats

Cited by 30 publications

References 57 publications

The essential function of CARD9 in diet‐induced inflammation and metabolic disorders in mice

The essential function of CARD9 in diet‐induced inflammation and metabolic disorders in mice

Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice

Honokiol Improves Liver Steatosis in Ovariectomized Mice

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