Ameliorative effect of naringin against thiram-induced tibial dyschondroplasia in broiler chicken

Jiang, Xiong; Li, Aoyun; Wang, Yaping; Iqbal, Mudassar; Waqas, Muhammad; Yang, Hao; Li, Zhixing; Mehmood, Khalid; Qamar, Hammad; Li, Jiakui

doi:10.1007/s11356-020-07732-5

Cited by 17 publications

(9 citation statements)

References 56 publications

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“…The balance between calcium and phosphorus in the feed is vital to leg health of broilers (10)(11)(12). To effectively improve the metabolism of calcium and phosphorus and reduce the occurrence of TD in broilers, functional feed additives to prevent leg disease in broilers need to be studied (13,14).…”

Section: Introductionmentioning

confidence: 99%

Quercetin Regulates Calcium and Phosphorus Metabolism Through the Wnt Signaling Pathway in Broilers

Wang

Ding

et al. 2022

Front. Vet. Sci.

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This study intended to explore the effect and mechanism of different doses of dietary quercetin on calcium and phosphorus metabolism to provide an experimental basis for preventing leg disease in broilers. A total of 480 1-day-old healthy Arbor Acre broilers were randomly allotted into four groups (0, 0.02, 0.04, 0.06%) for 42 days. Compared with control, 0.06% quercetin significantly increased the unit weight and the relative weight of tibia in broilers (P < 0.05). Meanwhile, phosphorus content and bone mineral density (BMD) were significantly increased by 0.06% dietary quercetin supplementation in tibia (P < 0.05). Ash of tibia was significantly increased by 0.04 and 0.06% quercetin in broilers (P < 0.05). In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers. The content of serum parathyroid (PTH) was significantly decreased by 0.02 and 0.06% quercetin (P < 0.05) in broilers. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the Wnt signaling pathway was a key signaling pathway of calcium and phosphorus metabolism in broilers which was significantly regulated by quercetin. The differentially expressed genes (DEGs) from transcriptome sequencing were validated with real-time quantitative PCR (RT-qPCR). In conclusion, 0.06% dietary quercetin supplementation improved calcium and phosphorus metabolism by regulating the Wnt signaling pathway in broilers.

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Section: Introductionmentioning

confidence: 99%

Quercetin Regulates Calcium and Phosphorus Metabolism Through the Wnt Signaling Pathway in Broilers

Wang

Ding

et al. 2022

Front. Vet. Sci.

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“…Chicks were allocated into two groups, a control group (n=50) and a thiram group (n=100). Both groups were fed with standard basal diet but thiram group received additionally tetramethyl thiuram disulphide (thiram) @ 50 mg/kg for the induction of disease according to Jiang et al (2020) after three days post-hatch. On day 7, fifty birds were allocated as FK228 group separated from the thiram group and injected Fk228 (Shanghai Biochempartner Co., Ltd. Shanghai, China) intraperitoneally @ 0.5 mg/kg/day.…”

Section: Experimental Designmentioning

confidence: 99%

Pea Aphid (Hemiptera: Aphididae) Population Responses to Selected Pea Cultivars and High Temperatures

Mastoi¹

2022

PJZ

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“…Birds with severe collisions are likely to be more susceptible to fractures during handling and ultimately lead to increased costs (Pines & Reshef, 2015). Symptoms of this disease include the appearance of a cartilaginous mass devoid of blood vessels, minerals, and opaque white in the growth plates of long bones that extends into the anterior metaphyseal region of the tibiotarsus and in some cases tarsometatarsus (Huang et al, 2019; Jiang et al, 2020; Waqas et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Also, various dithiocarbamates such as thiram have been used successfully to induce TD. In most recent studies, TD in chickens has been induced using thiram (Iqbal et al, 2018; Jiang et al, 2020; Li et al, 2007; Mehmood et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of cold stress on growth performance, carcass traits and tibia attributes in broiler chickens with thiram‐induced dyschondroplasia

Saeedi

Hassanabadi

Zaeemi

2022

Animal Physiology Nutrition

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The objective of this study was to investigate the effect of cold stress (CS) on growth performance and tibia attributes in broiler chickens with thiram‐induced dyschondroplasia (TD). Four hundred 10‐day‐old male broilers were randomly allocated into four groups including, NT0: normal temperature (NT) without thiram; NT50: NT + thiram; CS0: CS without thiram; and CS50: CS + thiram in a completely randomised. The birds in CS groups were placed at a constant temperature of 15 ± 1°C during 11–20 days. Thiram (50 mg/kg) was added to the diet during 11–14 days to induce TD. Results showed that main effects of CS and thiram significantly decreased body weight and daily weight gain during 11–42 days (p < 0.05). Feed intake in the thiram50 group was significantly lower than the group thiram0 during 25–42 days (p < 0.05). Feed conversion ratio in CS birds was significantly more than NT group during 25–42 days (p < 0.05). On day 16, tibia width (TW) and TW to tibia length (TL) ratio were significantly higher in CS chicks compared to the NT group. TW was significantly higher in thiram50 group than thiram0 group (p < 0.05). On day 19, TL in CS chicks was significantly shorter than NT (p < 0.05). On day 23, growth plate width (GPW) in thiram50 group was significantly higher than thiram0 birds. In general, thiram increased tibial GPW and CS decreased TD severity as well as decreased growth performance in broilers.

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Ameliorative effect of naringin against thiram-induced tibial dyschondroplasia in broiler chicken

Cited by 17 publications

References 56 publications

Quercetin Regulates Calcium and Phosphorus Metabolism Through the Wnt Signaling Pathway in Broilers

Quercetin Regulates Calcium and Phosphorus Metabolism Through the Wnt Signaling Pathway in Broilers

Pea Aphid (Hemiptera: Aphididae) Population Responses to Selected Pea Cultivars and High Temperatures

Effects of cold stress on growth performance, carcass traits and tibia attributes in broiler chickens with thiram‐induced dyschondroplasia

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