Ameliorative effect of Leflunomide on lung injury following an aspiration

Abstract

Background: We aimed to investigate the therapeutic effectiveness of lefl unomide (LEF) in lung injury after an aspiration of unknown pathophysiology. Material and methods: Forty-two healthy Sprague Dawley rats were anesthetized and allocated to six experimental groups: saline (S) aspirated, S+LEF, hydrochloric acid (HCl) aspirated, HCl+LEF, formula aspirated (FOR), and FOR+LEF. The treatment groups (S+LEF, HCl+LEF, and FOR+LEF) received 20 mg/kg/day intraperitoneal (i.p.) injection of LEF for seven days. At the end of the seven days, blood and tissue samples were taken from the rats for histopathological, biochemical, and immunohistochemical examination. Results: There was a signifi cant increase in serum levels of YKL-40, a chitinase-like protein, in the HCl group after the aspiration (p < 0.01). The increase in serum YKL-40 levels decreased signifi cantly with LEF treatment (p <0.01). There was no signifi cant difference in serum YKL-40 levels in the FOR group compared to the control group at pretreatment and in the FOR+LEF group at post-treatment. There was a signifi cant increase in serum thiobarbituric acid-reactive species (TBARS) values in the HCl and FOR groups compared to the control group (p =0.001 and p<0.01, respectively). In both treatment groups, the serum TBARS values signifi cantly decreased after treatment with LEF (p = 0.001 and p < 0.05, respectively). There was a signifi cant improvement in the histopathological scores, which deteriorated after the aspiration, and in the number of inducible nitric oxide synthase (iNOS)-positive cells after treatment with LEF. Conclusions: LEF can be a useful agent in the treatment of gastric content aspiration-induced acute lung injury (ALI) (Tab. 1, Fig. 5, Ref. 43). Text in PDF www.elis.sk.

A Cholinergic Poisoning Case Shaded with Foreign Body Aspiration Story

“…2 Gelişmekte olan ülkelerde pestisitler daha çok kırsal kesimde, kaza ile ya da öz-kıyım amaçlı alınmaktadır. 3 Budhathoki ve ark. kaza ile alıma bağlı zehirlenme olgularının beş yaş altında daha fazla olduğunu bildirmişlerdir.…”

“…Ardından 10-20 mg/kg/saat'lik infüzyon tedavisine geçilebilir. 3 PAM'ın AChE enzimini reaktive etme etkisi organofosfatın türü ve plazma konsantrasyonu ile ilişkili olup klinik yanıt süresi değişebilmektedir. Olgumuzda yanıt ikinci günden sonra alınmıştır.…”