Ameliorative effect of <i>Vernonia cinerea</i> in vincristine-induced painful neuropathy in rats

Thiagarajan, Venkata Rathina Kumar; Shanmugam, Palanichamy; Krishnan, Uma Maheswari; Muthuraman, Arunachalam

doi:10.1177/0748233712463779

Cited by 17 publications

(11 citation statements)

References 48 publications

(62 reference statements)

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“…Vincristine-injected mice also displayed functional (SFI) loss and oxidative stress in sciatic nerve in the present study. Pregabalin, a selective Ca v 2.2 (a2 -d subunit) channel antagonist, was used as a standard and protected the vincristine-induced hyperalgesic response in this study, which is in accord with previous report (Thiagarajan et al, 2012). In the present study, treatment with curcumin in vincristine-injected mice significantly increased the nociceptive threshold, decreased the oxidative stress and total calcium levels, and improved functional index in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 80%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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Section: Discussionsupporting

confidence: 80%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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“…16,50,51 Earlier reported data suggest that neuropathic pain has been linked with rise in neuronal calcium levels followed by enhance in the oxidative stress markers (free radicals) and inflammatory cytokines, etc. 50,52 Moreover, other mechanism which could be a possible reason behind vincristine-induced neuropathy are as follows: mitochondrial changes 53 ; increase in sodium ion current in DRG predisposing to paraesthesia and fasciculations 54 ; activation of calcium activated proteases calpains and caspases in DRG neurons 55 ; increase in 5-HT2A receptors on dorsal horn and DRG neurons 56 ; and dysfunction of the spinal NO/cGMP pathway. 57 In the present study, treatment with FA and GBA-attenuated vincristine induced alterations in nociceptive threshold (mechanical hyperalgesia, heat hyperalgesia, mechanical dynamic allodynia, and cold allodynia), electrophysiological changes (MNCV and SNCV), and histopathological analysis, suggesting its antinociceptive potential in vincristineinduced neuropathy.…”

Section: Discussionmentioning

confidence: 98%

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Vashistha

Sharma

Jain

2016

Nutritional Neuroscience

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The present study was designed to investigate the effect of ferulic acid (FA) in vincristine-induced neuropathic pain in rats. Vincristine (50 µg/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats. Various pain sensitive tests, viz., pinprick, hot plate, paint-brush, and acetone test were performed on different days (1, 6, 14, and 21) to assess the degree of mechanical hyperalgesia, heat hyperalgesia, mechanical dynamic allodynia, and cold allodynia, respectively. The electrophysiological and histopathological evaluations were also investigated. The tissue thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and total calcium were measured as the markers of inflammation and oxidative stress. FA (50 and 100 mg/kg, i.p.) and gabapentin (10 mg/kg, p.o.) were administered for 11 days. Administration of FA attenuated the vincristine-induced behavioral alteration along with electrophysiological and histopathological changes significantly (P < 0.05). FA also attenuated the vincristine-induced oxidative stress (TBARS, GSH, and total calcium levels) and inflammation (MPO, TNF-alpha, IL-6, and IL-10). It may be concluded that FA has ameliorative potential in mitigation of the painful states associated with vincristine-induced painful neuropathy that may further be attributed to anti-inflammatory actions with subsequent reduction in oxidative stress.

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“…Actually, neuropathic pain has been linked with a rise in neuronal calcium levels followed by enhancement of the oxidative stress markers (free radicals) and inflammatory cytokines, etc. 53 , 54 . This suggested that the inhibitory effect of MT on neuropathic pain might also be mediated by the calcium channels.…”

Section: Discussionmentioning

confidence: 99%

Matrine inhibits itching by lowering the activity of calcium channel

Geng

Shi

Fan

et al. 2018

Sci Rep

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Sophorae Flavescentis Radix (SFR) is a medicinal herb with many functions that are involved in anti-inflammation, antinociception, and anticancer. SFR is also used to treat a variety of itching diseases. Matrine (MT) is one of the main constituents in SFR and also has the effect of relieving itching, but the antipruritic mechanism is still unclear. Here, we investigated the effect of MT on anti-pruritus. In acute and chronic itch models, MT significantly inhibited the scratching behavior not only in acute itching induced by histamine (His), chloroquine (CQ) and compound 48/80 with a dose-depended manner, but also in the chronic pruritus models of atopic dermatitis (AD) and acetone-ether-water (AEW) in mice. Furthermore, MT could be detected in the blood after intraperitoneal injection (i.p.) and subcutaneous injection (s.c.). Finally, electrophysiological and calcium imaging results showed that MT inhibited the excitatory synaptic transmission from dorsal root ganglion (DRG) to the dorsal horn of the spinal cord by suppressing the presynaptic N-type calcium channel. Taken together, we believe that MT is a novel drug candidate in treating pruritus diseases, especially for histamine-independent and chronic pruritus, which might be attributed to inhibition of the presynaptic N-type calcium channel.

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Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats

Cited by 17 publications

References 48 publications

Effect of curcumin in mice model of vincristine-induced neuropathy

Effect of curcumin in mice model of vincristine-induced neuropathy

Ameliorative potential of ferulic acid in vincristine-induced painful neuropathy in rats: An evidence of behavioral and biochemical examination

Matrine inhibits itching by lowering the activity of calcium channel

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