Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

Badr, Osama; Abd-Eltawab, Hala M.; Sakr, Saber A.

doi:10.21608/jbaar.2016.106941

Cited by 19 publications

(9 citation statements)

References 29 publications

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“…Besides that, the decline in the level of albumin produced by the liver’s hepatocytes in EST–bearing mice, valuable markers for liver function, refers to the harmful effect of EAC that causes the decrease in the biosynthetic capacity of the liver to synthesize plasma protein. Also, EAC proliferation induced renal tissue injury and raised kidney function . Our results are matched with a recent study .…”

Section: Discussionsupporting

confidence: 91%

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Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

et al. 2022

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Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.

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Section: Discussionsupporting

confidence: 91%

“…Also, EAC proliferation induced renal tissue injury and raised kidney function. 67 Our results are matched with a recent study. 68 The changes in liver and kidney functions could be due to the generation of ROS that induces tissue damage by destroying cellular homeostasis.…”

Section: Discussionsupporting

confidence: 90%

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

et al. 2022

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“…Hepatic toxicity induced through tumor growth may be due to the extreme production of ROS that leads to oxidative stress and damage [ 46 , 64 , 65 ]. The present data indicated that treatment with APAN improved liver biomarkers, and when ETO was used, improvement also occurred.…”

Section: Discussionmentioning

confidence: 99%

Impact of Synthesized Indoloquinoline Analog to Isolates from Cryptolepis sanguinolenta on Tumor Growth Inhibition and Hepatotoxicity in Ehrlich Solid Tumor-Bearing Female Mice

Nofal

Elmongy

Hassan

et al. 2023

Cells

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The study evaluated the antitumor efficacy of APAN, “synthesized indoloquinoline analog derived from the parent neocryptolepine isolated from the roots of Cryptolepis sanguinolenta”, versus the chemotherapeutic drug etoposide (ETO) in Ehrlich solid tumor (EST)-bearing female mice as well as its protective effect against etoposide-triggered hepatic disorders. APAN showed an ameliorative activity against Ehrlich solid tumor and hepatic toxicity, and the greatest improvement was found in the combined treatment of APAN with ETO. The results indicated that EST altered the levels of tumor markers (AFP, CEA, and anti-dsDNA) and liver biomarker function (ALT, AST, ALP, ALB, and T. protein). Furthermore, EST elevated CD68 and anti-survivin proteins immuno-expressions in the solid tumor and liver tissue. Molecular docking studies were demonstrated to investigate their affinity for both TNF-α and topoisomerase II as target proteins, as etoposide is based on the inhibition of topoisomerase II, and TNF-α is quite highly expressed in the solid tumor and liver tissues of EST-bearing animals, which prompted the authors’ interest to explore APAN affinity to its binding site. Treatment of mice bearing EST with APAN and ETO nearly regularized serum levels of the altered parameters and ameliorated the impact of EST on the tissue structure of the liver better than that by treatment with each of them separately.

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“…Similarly, Badawy et al [66] indicated that ginger extract (200 mg/kg) ameliorates the histopathological and ultrastructure changes in the hepatocytes of the fetuses maternally injected with the antiepileptic drug gabapentin. Also, Badr et al [67] showed that ginger extracts at a dose of 120 mg/kg caused some ameliorations in the liver structure after solid tumor formation in mice. Gholampour et al [68] reported that ginger hydroalcoholic extract exerts a protective effect against ferrous sulfate-induced pathological changes in both rat liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

Modulatory effect of ginger on skeletal malformations, cell cycle, apoptosis and structural changes in the liver of rat fetuses prenatally exposed to labetalol

El–Borm

Gobara

Badawy

2023

Beni-Suef Univ J Basic Appl Sci

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Background Drug-induced liver damage with clinical symptoms has been related to labetalol in a number of instances. In addition to having a wide range of anti-inflammatory and antioxidant qualities, ginger also includes biotrace that are crucial in the fight against disease and skeletal deformity. In this study, we hypothesized that prenatal supplementation of ginger (200 mg/kg) attenuates skeletal malformation and hepatotoxicity mediated by labetalol during the organogenesis period. The tested dams were divided into four groups: control, ginger (200 mg/kg), labetalol (300 mg/kg) and combined group (labetalol and ginger at the same doses). Results The labetalol group showed various skeletal abnormalities represented by mandibular hypoplasia, costal separation and retardation in the ossification. Histological and ultrastructural examination of the fetal liver tissue revealed multiple pathological changes. DNA damage, G0/G1 cell cycle arrest and a high percentage of apoptosis were also detected in the fetal hepatocytes from labetalol groups through gel electrophoresis and flow cytometry using PI and annexin V/PI methods, respectively. Administration of ginger after labetalol caused an evident decrease in these skeletal malformations, structural changes, DNA damage, apoptosis and G0/G1 cell cycle arrest. Conclusions It can be concluded that ginger has great potential in attenuating the skeletal malformation, structural changes and cyto-genotoxicity of fetal hepatocytes upon prenatal exposure to labetalol.

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Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

Cited by 19 publications

References 29 publications

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

Impact of Synthesized Indoloquinoline Analog to Isolates from Cryptolepis sanguinolenta on Tumor Growth Inhibition and Hepatotoxicity in Ehrlich Solid Tumor-Bearing Female Mice

Modulatory effect of ginger on skeletal malformations, cell cycle, apoptosis and structural changes in the liver of rat fetuses prenatally exposed to labetalol

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