Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate

Dattani, J. J.; Rajput, Dhrupadsinh K; Moid, N.; Highland, Hyacinth; George, Linz-Buoy; Desai, Ketaki R.

doi:10.1016/j.etap.2010.04.001

Cited by 34 publications

(22 citation statements)

References 47 publications

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“…The high MDA concentrations of the pituitary and the testicular tissues in the CPF group are indications of the level of lipoperoxidative changes, reflecting alteration in structural and perhaps functional status of these organs. Lipid peroxidation involves the formation and propagation of lipid radicals, the uptake of oxygen and rearrangement of the double and unsaturated lipids, resulting in a variety of degraded products that eventually cause destruction of membrane lipids [37] . However, pretreatment with melatonin has been shown by the present study to decrease the testicular and pituitary MDA concentrations, indicating its anti-lipoperoxidative effect.…”

Section: Discussionmentioning

confidence: 99%

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen

Ambali

Ayo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Umosen

Ambali

Ayo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…The administration of curcumin, an herbal antioxidant obtained from Curcuma longa , prevented hepatotoxicity in rats treated with chloroquine [154]. Likewise, the administration of glutathione promoted reduced parasitemia and increased survival of mice infected with P. berghei [155].…”

Section: Potential Benefit Of Adjuvant Antioxidant Therapy For Malmentioning

confidence: 99%

Oxidative Stress in Malaria

Percário

Moreira

Gomes

et al. 2012

IJMS

269

197

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Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year. Despite the significant effort to eradicate this dangerous disease, lack of complete knowledge of its physiopathology compromises the success in this enterprise. In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.

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“…Curcumin/tetrahydrocurcumin (THC) exhibits a wide range of pharmacological activities, including anti‐oxidant, anti‐toxic, anti‐inflammatory, and having potentially chemotherapeutic properties (Anand et al, ; Tyagi et al, ). The use of THC has been reported as a therapeutic agent to mitigate various kinds of toxicity including cardiotoxicity (Swamy, Gulliaya, Thippeswamy, Koti, & Manjula, ), nephrotoxicity (Ueki, Ueno, Morishita, & Maekawa, ), hepatotoxicity (Dattani et al, ), and neurotoxicity (Sharma, Suhalka, Sukhwal, Jaiswal, & Bhatnagar, ). Treatment with THC was found to modulate mitochondrial dysfunction and its property as an antioxidant and widely thought to be responsible for its protective effects in mitochondria (Zhu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Tetrahydrocurcumin ameliorates homocysteine‐mediated mitochondrial remodeling in brain endothelial cells

Vacek

Behera

George

et al. 2017

Journal Cellular Physiology

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Homocysteine (Hcy) causes endothelial dysfunction by inducing oxidative stress in most neurodegenerative disorders. This dysfunction is highly correlated with mitochondrial dynamics such as fusion and fission. However, there are no strategies to prevent Hcy-induced mitochondrial remodeling. Tetrahydrocurcumin (THC) is an anti-inflammatory and anti-oxidant compound. We hypothesized that THC may ameliorates Hcy-induced mitochondria remodeling in mouse brain endothelial cells (bEnd3) cells. bEnd3 cells were exposed to Hcy treatment in the presence or absence of THC. Cell viability and autophagic cell death were measured with MTT and MDC staining assay. Reactive oxygen species (ROS) production was determined using DCFH-DA staining by confocal microscopy. Autophagy flux was assessed using a conventional GFP-microtubule-associated protein 1 light chain 3 (LC3) dot assay. Interaction of phagophore marker LC-3 with mitochondrial receptor NIX was observed by confocal imaging. Mitochondrial fusion and fission were evaluated by western blot and RT-PCR. Our results demonstrated that Hcy resulted in cell toxicity in a dose-dependent manner and supplementation of THC prevented the detrimental effects of Hcy on cell survival. Furthermore, Hcy also upregulated fission marker (DRP-1), fusion marker (Mfn2), and autophagy marker (LC-3). Finally, we observed that Hcy activated mitochondrial specific phagophore marker (LC-3) and co-localized with the mitochondrial receptor NIX, as viewed by confocal microscopy. Pretreatment of bEnd3 with THC (15 μM) ameliorated Hcy-induced oxidative damage, mitochondrial fission/fusion, and mitophagy. Our studies strongly suggest that THC has beneficial effects on mitochondrial remodeling and could be developed as a potential therapeutic agent against hyperhomocysteinemia (HHcy) induced mitochondrial dysfunction.

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Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate

Cited by 34 publications

References 47 publications

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

Oxidative Stress in Malaria

Tetrahydrocurcumin ameliorates homocysteine‐mediated mitochondrial remodeling in brain endothelial cells

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