Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice

Choudhary, Kailash M.; Mishra, Awanish; Poroikov, Vladimir; Goel, Rajesh Kumar

doi:10.1016/j.ejphar.2013.02.012

Cited by 107 publications

(64 citation statements)

References 55 publications

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“…Curcumin protected cultured neurons against direct oxidative insults including exposure to copper , hydrogen peroxide (Ray et al, 2011), and tert-butyl hydroperoxide . In vivo studies in rats and mice demonstrated that curcumin treatment ameliorates learning and memory deficits caused by exposure to arsenic (Yadav et al, 2011), Ab (Ahmed et al, 2010, and severe epileptic seizures (Choudhary et al, 2013). In cell culture and mouse models of PD, curcumin protected dopaminergic neurons against glutathione depletion and protein oxidation (Jagatha et al, 2008).…”

Section: A Oxidative Stressmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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Section: A Oxidative Stressmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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“…Furthermore, the L-NAME, 7-NI, AG, or L-ARG was administered 15 min before curcumin was injected, and the curcumin was administered 20 min before PTZ was injected. The drug doses that were used in the present study were selected according to previous studies [16][17][18].…”

Section: Animalsmentioning

confidence: 99%

The involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats

Zhu

Liu

et al. 2015

BME

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Abstract. In this study, it was investigated whether a NO signaling pathway is involved in the anti-epileptic effect of curcumin on pentylenetetrazol (PTZ)-kindled rats. PTZ-kindled rats received different doses of curcumin that were administered intraperitoneally for 24 days. Either a non-selective inhibitor of nitric oxide synthase (NOS) (N-nitro-L-arginine methyl ester (L-NAME)), a selective inhibitor of neuronal NOS (7-Nitroindazole (7-NI)), a selective inhibitor of inducible NOS (aminoguanidine (AG)), or a NO precursor (L-arginine (L-ARG)) was administered chronically to evaluate the role of NO in curcumin's anti-seizure effect. A chronic administration of curcumin (200 mg/kg) was most effective for decreasing the mean frequency of epileptiform discharge. Furthermore, a pretreatment with L-NAME or 7-NI augmented the anti-epileptic effect of curcumin. In contrast, AG failed to significantly alter the anti-epileptic effect of curcumin. A pretreatment with L-ARG temporally reversed the anti-epileptic effect of curcumin in the early stage, but in the late stage, it potentiated curcumin's anti-epileptic effect. These findings suggest that the L-arginine-nitric oxide pathway may be involved in the anti-epileptic properties of curcumin, and that the role of nNOS (and not iNOS) is prominent in this neuroprotective feature.

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“…Recent preclinical studies demonstrated that curcumin may exhibit promising anticonvulsant effect [10,11] as well as potential antiepileptogenic effect [12,13] . It also has been shown to possess protective effects in ameliorating cognitive impairments and anxiety in epileptic animals [11,13,14] . These benefits highlighted curcumin as a potential antiepileptic agent for clinical management.…”

Section: Research Papermentioning

confidence: 99%

“…the neuroprotective effects of curcumin on behavioural changes in epileptic animal, different models of epilepsy (mainly pentylenetetrazol-induced epilepsy model) were employed in these studies [11,13,14] .…”

Section: The Effect Of Curcumin On Anxiety and Recognition Memory In mentioning

confidence: 99%

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

Yow

Ahmad²,

Azmi³

et al. 2017

Journal of Pharmaceutical Sciences

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Yow, et al.: Anxiety and Recognition Memory Alteration by CurcuminThe effect of curcumin had been studied on anxiety and recognition memory in kainic acid-induced epilepsy. A single dose of intraperitoneal kainic acid (10 mg/kg) was used to induce status epilepticus in female Wistar rats, followed by respective treatments (vehicle dimethyl sulfoxide 50%, curcumin 100 mg/kg/d or levetiracetam 100 mg/kg/d) on the next day for 7 d, with minimum of six rats per group. The behavioural tests were performed before seizure induction and after treatment. Vehicle-treated epileptic rats showed an increase in anxiety-like behaviours in the open field test, which less observed in the light/dark box test. Levetiracetam-treated epileptic rats exhibited anxiolytic behaviours in both the tests. Curcumin-treated epileptic rats exhibited not much difference in anxiety-like behaviour before and after the treatment in open field test, but exhibited anxiolytic behaviours in light/dark box test. Kainic acid impaired the both spatial and non-spatial recognition memories of the rats. Curcumin treatment showed reversal in the non-spatial recognition impaired by kainic acid. In conclusion, kainic acid increases anxiety-like behaviours and impaired recognition memories during the early phase of epileptogenesis and curcumin was potentially improved anxiety and non-spatial recognition memory impaired by kainic acid. These benefits highlighted the potential effect of curcumin to improve psychiatric disorders in epilepsy.

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Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice

Cited by 107 publications

References 55 publications

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

The involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

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