Ameliorative effect of black raspberry anthocyanins on diabetes retinopathy by inhibiting axis protein tyrosine phosphatase 1B-endoplasmic reticulum stress

Xiao, Ting; Yuan, Zhi Min; Tian, Fei; Huang, Feilong; Cheng, Xingyan; Wu, Aiping; Tao, Ling; Guo, Zhenghong; Shen, Xiangchun

doi:10.1016/j.jff.2023.105696

Cited by 1 publication

(2 citation statements)

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“…Anthocyanins are natural water-soluble pigments found inside the vacuoles in the cytosol and they contribute to the reddish-blue color of many fruits and vegetables. Black raspberry-derived anthocyanins (BRAs) have been extensively studied and demonstrated to regulate Nrf2 gene expression, attenuate ROS levels, reduce caspase-1-induced inflammation, and lower VEGFA levels, resulting in the melioration of blood glucose, lipid dysmetabolism, and retinopathy in diabetic rats [ 104 , 105 ]. Cyanidin-3-glucoside (C3G), also called chrysanthemin, is one of the most widely distributed anthocyanins found in nature.…”

Section: Nutraceuticalsmentioning

confidence: 99%

“…Similar to BRAs, C3G showed protective effects in in vivo and in vitro models of DR but gained more attention for its relative stability and easier absorbance [ 106 , 107 , 108 ]. Molecular docking analysis revealed that C3G could combine well with 78-kDa glucose-regulated protein (GRP78), a major endoplasmic reticulum (ER) chaperone protein, hence regulating ER stress [ 105 , 109 ]. In a recent open-label clinical trial, oral supplementation of 320 mg/day of anthocyanins for 4 weeks significantly reduced the pro-inflammatory biomarkers (IL-6, IL-18, and TNF-α) in T2DM patients [ 110 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

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Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.

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Section: Nutraceuticalsmentioning

confidence: 99%