Ameliorative effect of biofabricated ZnO nanoparticles of <i>Trianthema portulacastrum</i> Linn. on dermal wounds <i>via</i> removal of oxidative stress and inflammation

Yadav, Ekta; Singh, Deepika; Yadav, Pallavi; Verma, Amita

doi:10.1039/c8ra03500h

Cited by 42 publications

(16 citation statements)

References 75 publications

(104 reference statements)

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“…Metal analysis by EDX spectra showed presence of strong peaks of zinc as well as oxygen atom. Images of ZnOTP (utilized in current work) characteristics can be found in our previous study 36 …”

Section: Resultsmentioning

confidence: 99%

“…TP has been explored for possessing various therapeutic properties against different ailments, that is, migraine, rheumatism, liver and kidney disease, inflammation, diabetes, wound healing and cognitive impairment 32‐35 . Numerous bioactive secondary metabolites are reported to exist in TP such as alkaloids, phenolic compounds, flavonoids, terpenes, steroidal saponins, etc 36 . Considering the neuroprotective potential of TP, the key objective of the current study was to biofabricate, evaluate and explore the effect of TP leaves extract mediated ZnO nanoparticles (ZnOTP) on spatial cognitive behavior and insights into the possible underlying mechanism of action by estimation of zinc content, oxidative stress as well as neurotransmitters level in mice brain.…”

Section: Introductionmentioning

confidence: 99%

“…34 The antioxidant effect of ZnOTP may be credited to formation of electrostatic bond between positively charged ZnONP, that is, ZnO = Zn 2+ + O 2− , and functional groups of negatively charged secondary metabolites, that is, COO − , O − . Thus, the surface adsorbed phytoconstituents onZnONP helps to synergize the antioxidant effect 36.…”

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confidence: 99%

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Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

Yadav

2020

Environmental Toxicology

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Current work was designed to explore the effect of ZnO nanoparticles (ZnONP) biofabricated by using Trianthema portulacastrum (TP) leaves extract on mice brain hippocampus. ZnO nanoparticles of TP leaves (ZnOTP) were synthesized by co‐precipitation method and further characterized by using various techniques such as UV‐Vis spectrophotometer, Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared (FTIR), and Energy Dispersive X‐ray (EDX). ZnOTP were evaluated for in vitro antioxidant activity, in vivo behavior models (for assessment of cognitive ability), acetylcholinesterase (AChE) activity along with other neurotransmitters content determination, estimation of various oxidative stress parameters and analysis of zinc content in the brain as well as plasma. Histopathological evaluation of the brain hippocampus of each group was performed to corroborate the statistical results. Spherical ZnOTP of 10 to 20 nm size embedded with different phytoconstituents of TP was confirmed. Results of our study revealed a significant memory deficit in mice treated with ZnOTP. Neuronal degeneration was also observed via a significant increase in AChE activity and oxidative stress levels in the brain of mice administered with ZnOTP. Exposure of ZnOTP was also found responsible for modulation of neurotransmission in hippocampus area. Further, ZnOTP disturbed the zinc homeostasis in hippocampus via elevation of zinc content in brain as well as plasma. Histopathology of hippocampus supported the damaging impact of ZnOTP by an increase in vacuolated cytoplasm and focal gliosis in groups treated with ZnOTP. Results demonstrated the neurotoxic effect of ZnOTP on brain hippocampus via cognitive impairment by alteration of neurotransmitter level, zinc content and oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

Yadav

2020

Environmental Toxicology

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“…These greener nanoparticles showed strong in vitro anti-inflammatory activity. Topical treatment with ZnOTP on injured skin tissue led to rapid closure and wound healing due to reduced collagen fibers, tissue granulation, antioxidant pressure, and inflammatory reactions [ 206 ].…”

Section: Various Metallic Nanocarriers In Drug Delivery Systemsmentioning

confidence: 99%

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

2022

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Over the past few years, nanotechnology has been attracting considerable research attention because of their outstanding mechanical, electromagnetic and optical properties. Nanotechnology is an interdisciplinary field comprising nanomaterials, nanoelectronics, and nanobiotechnology, as three areas which extensively overlap. The application of metal nanoparticles (MNPs) has drawn much attention offering significant advances, especially in the field of medicine by increasing the therapeutic index of drugs through site specificity preventing multidrug resistance and delivering therapeutic agents efficiently. Apart from drug delivery, some other applications of MNPs in medicine are also well known such as in vivo and in vitro diagnostics and production of enhanced biocompatible materials and nutraceuticals. The use of metallic nanoparticles for drug delivery systems has significant advantages, such as increased stability and half-life of drug carrier in circulation, required biodistribution, and passive or active targeting into the required target site. Green synthesis of MNPs is an emerging area in the field of bionanotechnology and provides economic and environmental benefits as an alternative to chemical and physical methods. Therefore, this review aims to provide up-to-date insights on the current challenges and perspectives of MNPs in drug delivery systems. The present review was mainly focused on the greener methods of metallic nanocarrier preparations and its surface modifications, applications of different MNPs like silver, gold, platinum, palladium, copper, zinc oxide, metal sulfide and nanometal organic frameworks in drug delivery systems.

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“…For the current study, we have selected Trianthema portulacastrum L (TP), a plant of Aizoaceae family, indigenous to Asia, tropical America and Southeast Africa. It grows like a weed, especially in areas with heavy rainfall and a good amount of irrigation in India, Sri Lanka, Pakistan and Bangladesh (Yadav et al, 2018a;Yadav et al, 2019). TP is also a well-known Indian traditional medicinal herb of the Ayurvedic system and it has been traditionally utilized for the treatment of broad-spectrum ailments such as jaundice, inflammation ulcer, anemia, liver disease and migraine.…”

Section: Introductionmentioning

confidence: 99%

In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential

Yadav

Verma

2021

Front. Pharmacol.

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Rich amount of phenolic compounds are available in Trianthema portulacastrum L. (TP) leaves and are traditionally utilized as a wound dressing material. Oxidative stress and inflammation affect the Wnt/β-catenin pathway by modulating the glycogen synthase kinase-3β (GSK) activity subjected to delay in wound healing. The objective of the current study was to explore the wound healing effect of ferric oxide nanoparticles biosynthesized with fractionated TP extract (FeTP). The ability of TP active components (polyphenols) to inhibit the GSK was explored by using molecular docking studies. FeTP were synthesized, characterized, utilized to prepare an ointment and its efficacy was investigated against full-thickness dermal wounds. Different wound healing parameters, level of enzymatic antioxidants, hydroxyproline content and tissue cytokines level were analyzed. Histopathology was performed to confirm the healing by newly formed tissue architecture. Rats treated with FeTP showed significantly swift healing with faster wound contraction rate, high tensile strength and hydroxyproline content along with the utilization of less time for epithelialization. Histopathological study also validated the potential wound healing effect of FeTP with complete re-epithelialization. The results of the present study cumulatively revealed that the green synthesized FeTP ointment approach may serve as a potential tool for dermal wound healing.

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Ameliorative effect of biofabricated ZnO nanoparticles of Trianthema portulacastrum Linn. on dermal wounds via removal of oxidative stress and inflammation

Abstract: The curative efficacy of a green synthesized zinc oxide nano-ointment on wound healing was investigated.

Cited by 42 publications

References 75 publications

Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential

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