Ameliorative effect of Ananus comosus peel on 7, 12 dimethylbenz(α)anthracene induced mammary carcinogenesis with reference to oxidative stress

Kalaiselvi, M.; Gomathi, D.; Ravikumar, Ganesan; Devaki, Kanakasabapathi; Uma, C.

doi:10.1016/s2221-6189(13)60089-x

Cited by 16 publications

(14 citation statements)

References 32 publications

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“…CAT is another key enzyme due to its ability to convert H 2 O 2 into H 2 O and molecular O 2 . GPx protects the membrane lipids from oxidative damage and catalyzes the reaction of hydroperoxides with reduced glutathione to form disulphide glutathione (GSSG) 44,45 . While, GST plays a critical role in the detoxification process of xenobiotic to non‐toxic products, protecting against electrophiles and oxidative stress 46 .…”

Section: Discussionmentioning

confidence: 99%

Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats

El‐Demerdash

El-Magd

El‐Sayed

2021

Environmental Toxicology

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Silicon dioxide nanoparticles (SiO2NPs) are extensively used in cosmetics, food, and drug delivery. The main mechanism of SiO2NPs toxicities depends on oxidative stress. Ginseng (Panax ginseng Meyer) is used in various medicinal applications because of its antioxidant efficiency. Therefore, the present study was carried out to investigate the possible combated role of ginseng against SiO2NPs toxicity in rat liver. Thirty‐five male rats (160–180 g) were allocated into five groups of seven rats each, randomly. The first group was used as a control while groups 2, 3, 4, and 5 were treated orally with ginseng (Gin; 75 mg/kg, 1/10 LD50), SiO2NPs, (200 mg/kg, 1/10 LD50), Gin + SiO2NPs (protection group), and SiO2NPs + Gin (therapeutic group) for 5 weeks, respectively. Treatment with SiO2NPs increased lipid peroxidation, liver function enzymes, and decreased antioxidant enzymes (SOD, CAT, GPx, GST) activity and non‐enzymatic antioxidant (GSH) level. SiO2NPs administration motivated liver apoptosis as revealed by the upregulation of the apoptotic genes, Bcl2‐associated x protein (Bax), and Beclin 1 and downregulation of the anti‐apoptotic gene, B‐cell lymphoma 2 (Bcl2) as well as increase in DNA damage. Also, SiO2NPs administration caused inflammation as indicated by upregulation of the inflammation‐related genes (interleukin 1 beta [IL1β], tumor necrosis factor‐alpha [TNFα], nuclear factor kappa B [NFκB], cyclooxygenase 2 [Cox2], transforming growth factor‐beta 1 [TGFβ1]) as well as cell cycle arrest in the G0/G1 phase of liver cells. Moreover, histopathological examination proved the biochemical and molecular perturbations occurred due to SiO2NPs toxicity. On the other hand, ginseng caused a significant modulation on the deleterious effects induced by SiO2NPs in rat liver. In conclusion, ginseng has a potent preventive effect than the therapeutic one and might be used in the treatment of SiO2NPs hepatotoxicity.

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Section: Discussionmentioning

confidence: 99%

Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats

El‐Demerdash

El-Magd

El‐Sayed

2021

Environmental Toxicology

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“…Glutathione Peroxidase (GPx) is a cytoplasmic enzyme that catalyzes the detoxification of H 2 O 2 to H 2 O using the reducing equivalents of glutathione. Both, two third of GPx found in liver cytosol and one third in mitochondria, work together with glutathione in breaking down H 2 O 2 or other organic hydroperoxides to nontoxic products at the expenditure of GSH, which is vital in fighting ROS‐evoked cellular abnormalities (Kalaiselvi, Gomathi, Ravikumar, Devaki, & Uma, ). The decline in SOD activity leads to down regulation of H 2 O 2 production.…”

Section: Discussionmentioning

confidence: 99%

Dose‐dependent chemopreventive effects of citronellol in DMBA‐induced breast cancer among rats

Jayaganesh

Pugalendhi

Subramaniyan

2019

Drug Development Research

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Breast cancer is one of the most common cancers among women world wide and its incidence is on tremendous increase. The present study is aimed to analyze the dose‐dependent chemopreventive efficacy of citronellol on 7,12‐dimethylbenz(a)anthracene (DMBA)‐induced rat mammary carcinogenesis. The mammary tumor was induced through a single dose of DMBA (25 mg/rat) injected subcutaneously near the mammary gland of rats. In DMBA‐injected rats, 100% tumor incidence, increased tumor volume, and tumor burden along with loss of body weight were observed. Biochemical analysis revealed the increased levels of phase I detoxification proteins (cytochrome P450 and b5) and decreased activities of phase II detoxification enzymes (glutathione‐S‐transferase and glutathione reductase) in hepatic and mammary tissues. The levels of enzymatic and non‐enzymatic antioxidants (superoxidedismutase, catalase, glutathione peroxidase, and (GPx) and reduced glutathione) were decreased and lipid peroxidation by‐products (thiobarbituric acid reactive substance and lipid hydroperoxide) got increased in plasma and mammary tissues. Oral administration of different doses of citronellol (25, 50, and 100 mg/kg body weight) to DMBA‐treated rats for 16 weeks absolutely inhibited the tumor incidence and restored the biochemical parameters near to normal level in 50 and 100 mg doses whereas the histopathological studies also supported the biochemical findings. Hence, the result suggests that the citronellol of 50 mg/kg body weight exerted significant chemopreventive effects and can be considered as a minimum optimum dose in the prevention of mammary carcinogenesis.

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“…loss [26]. The weight loss indicates poor diagnosis and tinier survival time for cancer patients [27].…”

Section: Discussionmentioning

confidence: 99%

Anticancer Effect of Methanolic Extract of Annona Squamosa on Mammary Carcinoma in Rats With Reference to Glycoprotein Components, Lysosomal, and Marker Enzymes

Nandhakumar¹,

Parameswaran²,

Panchanatham

2017

Asian J Pharm Clin Res

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Objectives:The aim is to evaluate the anticancer potential of Annona squamosa (AS) against 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats. Methods:The tumor was induced in Sprague-Dawley rats by gastric intubation of 25 mg DMBA in 1 ml olive oil. After 3 months of induction period, the methanolic extract of AS at different doses of 100, 150, 200, 250, and 300 mg/kg body weight were administered orally a dose per day to mammary carcinoma-bearing rats for 45 days. The serum and tissue levels of glycoprotein components as well as the activities of marker enzymes and lysosomal enzymes were measured in DMBA-induced mammary carcinoma-bearing rats.Results: Administration of AS resulted in decrease in the levels of marker and lysosomal enzymes and also alterations in the body weight and tumor volume were also restored to near normalcy in a dose-dependent manner. The results of the present study indicate that AS has anticancer effect and it exhibits its potential effect at the dosage of 200 mg/kg body weight in mammary carcinoma-bearing rats. Conclusions:Based on the results obtained, it can be concluded that the methanol extract of AS possesses anticancer properties. Further study is needed to isolate the active principle of this extract responsible for anticancer activity to develop the future pharmaceuticals.

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Ameliorative effect of Ananus comosus peel on 7, 12 dimethylbenz(α)anthracene induced mammary carcinogenesis with reference to oxidative stress

Cited by 16 publications

References 32 publications

Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats

Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats

Dose‐dependent chemopreventive effects of citronellol in DMBA‐induced breast cancer among rats

Anticancer Effect of Methanolic Extract of Annona Squamosa on Mammary Carcinoma in Rats With Reference to Glycoprotein Components, Lysosomal, and Marker Enzymes

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