Ameliorative activity of Adansonia digitata fruit on high sugar/high fat diet-simulated Metabolic Syndrome model in male Wistar rats

Suliman, Hayat Mohamed; Osman, Bashier; Abdoon, Iman Hassan; Saad, Ahmed; Khalid, Hassan

doi:10.1016/j.biopha.2020.109968

Cited by 17 publications

(13 citation statements)

References 62 publications

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“…However, this finding in rodents is controversial. Studies using hypercaloric diets found induction of NAFLD whenever hepatomegaly is present (Parafati et al, 2015;Omagari et al, 2020;Suliman et al, 2020), while in other studies, accumulation of fat in the liver is confirmed without any change in the weight of the organ (Macedo et al, 2012;de Almeida et al, 2016;Wang et al, 2019). Thus, it is possible to assume that the presence of 13.8 6 1.9 22.4 6 6.4** Hepatic cholesterol (mg/g) 4.9 6 0.3 7.4 6 1.4*** Notes: Control is the group of animals that received standard lab chow (Nuvilab CR-1V R ) and water ad libitum; cafeteria is the group of animals that received cafeteria diet and water ad libitum.…”

Section: Discussionmentioning

confidence: 99%

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Gomes

Costa

Rocha-Gomes

et al. 2020

NFS

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Purpose The purpose of this paper is to evaluate the pathological, biochemical and redox state parameters of liver tissue in Wistar rats treated from birth to adulthood (119 days) with cafeteria diet. Design/methodology/approach During the lactation, 6 liters of Wistar rats (dam + 8 pups each) were fed one of two diets: control (CTRL; n = 3) or cafeteria (CAF; n = 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (CTRL or CAF; n = 18) until adulthood. The following parameters were evaluated: absolute and relative liver weight; blood, liver and feces biochemistry; liver histology; and redox state of the liver. Findings When assessing the relative and absolute organ weight, no significant differences were found between the groups. The Cafeteria group exhibited higher values of serum LDL-c (p = 0.008), VLDL-c (p = 0.03) and triglycerides (p = 0.01), as well as several micro and macrovacuoles of fat accumulation, higher hepatic lipid (p = 0.03) and cholesterol (p = 0.0001) levels regarding Control group. Cafeteria group showed greater expression of glutathione-s-transferase (p = 0.03) and superoxide dismutase (p = 0.005) enzymes compared to the control group. In the case of the markers of oxidative stress, there was no difference between the groups. Originality/value A simple and standardized cafeteria diet caused an accumulation of fatty acids in liver tissue, inducing a state of hepatic steatosis besides an increased expression of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 99%

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Gomes

Costa

Rocha-Gomes

et al. 2020

NFS

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“…Additionally, fatty acids such as linoleic, palmitic, and oleic acids were found in tree extracts [21,25]. Investigations have also shown that considerable amounts of amino acids were found, such as methionine, L. arginine, lysine, and proline [8,10,18,[23][24][25][26][27]29,30,[32][33][34][35][36][37]. With such components, it is no wonder that the tree has been known as "the chemist tree" as these compounds possess countless medicinal and pharmaceutical benefits.…”

Section: Review Mineral Contents and Chemical Composition Of The Ad Treementioning

confidence: 99%

“…Antioxidant [10,26,30,33,34,39,40], hypoglycemic and antidiabetic effects [13,24,[39][40][41]. Also enhances cognitive performance [31,42].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…Vitamin C, Ca, and Mg Anti-inflammatory effect (vitamin C) [10], and potentially improve anemia cases [28].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…The whole components of the tree (fruit, leaves, seeds, and cortex) have been traditionally used as a medicine for several diseases, such as fever, diarrhea, malaria, cough, dysentery, hemoptysis, tuberculosis, microbial infections, and worms [2,4,5,7], while the seeds and oil are used to treat muscle wounds, dandruff, and other skin diseases [7,9]. These therapeutic uses were justified lately in the literature and linked to the immunostimulant, antioxidant, analgesic, antiviral, antimicrobial, anticarcinogenic, anti-depressive, hepatoprotective, cardioprotective, antidiabetic, and anti-inflammatory potentials of the tree's components [2,5,7,[10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Potential Uses of Baobab Tree's Medicinal Effects in Dentistry: A Literature Review

Abuljadayel

2023

Cureus

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Adansonia digitata (Baobab) tree is an African tree with a long history in traditional medicine. The local inhabitants of Africa have been using the different tree components to treat medical diseases, such as fever, diarrhea, malaria, cough, dysentery, and microbial infections. Recently, the tree gained the attention of scientists due to its medical and pharmaceutical properties and nutritional values, which generated a myriad number of investigations regarding its phytochemical and macro-and micronutrient contents. The fruit pulp is especially rich in vitamin C, pectin, fibers, and minerals such as calcium, magnesium, potassium, phosphorus, zinc, iron, and copper. Additionally, the leaves contain high levels of calcium, while the seeds are considered a good source of protein and fat. Altogether, they contain a variety of polyphenols, fatty acids, and amino acids. The tree extracts possess potent antioxidant, cell-protective, and anti-inflammatory activities. However, no information was found in the literature about the use of Baobab tree products in the dental field. The aim of this review is to discuss the well-documented medical effects and chemical and mineral components of the different Baobab tree parts from a dental point of view to open more areas of research concerning its potential applications in the dental field. Antioxidants and vitamin C are known to help in maintaining healthy periodontal and gingival tissues. They also help in wound healing and alveolar bone integrity. Moreover, phytochemicals and phenolic compounds have been utilized in controlling dental plaque and manufacturing intracanal medications as they manifest antimicrobial and anti-inflammatory activities. Furthermore, calcium and phosphorus incorporation in dental biomaterials is commonly used in vital pulp therapy and repairing bone defects. After reviewing the reported medicinal and pharmaceutical activities of the Baobab tree, it can be inferred that the tree extracts possess potential uses in the dental field, which requires further investigation for validation.

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Adansonia digitata and its use in neuropathic pain: Prostaglandins and beyond

Oyewole

Alli-Oluwafuyi

Nafiu

et al. 2022

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

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Ameliorative activity of Adansonia digitata fruit on high sugar/high fat diet-simulated Metabolic Syndrome model in male Wistar rats

Cited by 17 publications

References 62 publications

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

The Potential Uses of Baobab Tree's Medicinal Effects in Dentistry: A Literature Review

Adansonia digitata and its use in neuropathic pain: Prostaglandins and beyond

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