Amelioration of Uranyl Acetate Induced Toxicity on Male Rats by Using Hypericum Perforatum Herb

Abstract

The present study was performed to estimate the protective effect of hypericum perforatum (HCP) powder and its oil against uranyl acetate induced toxicity in male rats. Thirty male Albino rats were divided into two groups, group (1) (n=6) normal control. Group (2) (n=24) control positive were daily treated for 28 days with uranyl acetate 75 mg/kg/rats/day by oral intubation then divided into four groups: group (2) control positive (untreated)., group (3) HCP powder 5 mg\kg/diet., group (4) HCP oil 5 ml\kg/rats. Group (5) mixture HCP powder mg\kg/diet & oil 5 ml/kg/rats. The protective groups showed significant decrease in serum total cholesterol, triglycerides, LDL cholesterol, ALT, AST, urea, creatinine, uric acid, and MDA. While body weight gain (BWG), HDL cholesterol, SOD and GSH were significantly increased compared to (+ve) group. The HCP powder & oil are readily available supplier of polyphenols with great antioxidative are considered as functional food ingredients since they affect physiological and biochemical processes in rats and human beings, resulting in better health and improved the symptoms of uranyl acetate toxicity and prevent its complications. So, this research suggest that the anti-inflammatory and antioxidant properties of HCP are dependent on the flavonoid contents of the HCP.