Amelioration of PM2.5-induced lung toxicity in rats by nutritional supplementation with biochanin A

Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease

“…It was clearly showed that biochanin A could inhibit the number of total inflammatory cells, neutrophils, eosinophils, and levels of cytokines, including IL-2, IL-4, IL-5, and TNF- α , in BALF of the mice [ 36 ]. In a PM 2.5 -exposed rat model, Biochanin A decreased apoptosis and the levels of proinflammatory factors including TNF- α , IL-2, IL-6, and IL-8 [ 37 ].…”

Mechanism of biochanin A alleviating PM2.5-induced oxidative damage based on an XRCC1 knockout BEAS-2B cell model

“…27,28 The previous research of our group showed that oxidative stress, as the main enrichment pathway of differential proteins in response to PM 2.5 , is one of the key molecular mechanisms by which BCA attenuates PM 2.5 -induced lung injury; based on the results of bioinformatics and proteomics analysis, XRCC1 was selected as one of the potential targets of BCA in the prevention and treatment of PM 2.5 -induced lung injury. [15][16][17] XRCC1 is a core protein of the BER/DNA damage repair pathway, which is involved in repairing single-strand breaks of DNA, removing and repairing bases along with DNA polymerase. 18,29 The BER pathway proteins maintain genomic stability and reduce the risk of lung injury caused by environmental exposure, meanwhile improving human sensitivity to drugs.…”

“…34,35 Our previous research has also confirmed this. [15][16][17] Li et al 36 provide another interesting mechanism of PM 2.5 -induced lung injury from the perspective of lung microbiota and metabolites. The research on the mechanism of PM 2.5 -induced lung injury is deepening and expanding gradually.…”

“…Western blot results showed that the differential expression of XRCC1 protein was the most significant, so XRCC1 was initially identified as a potential target of BCA. 17 XRCC1 and its base excision repair (BER) pathway repair the most common forms of oxidative DNA damage. 18 Although previous studies have shown that XRCC1 is involved in PM 2.5 -induced lung injury, the mechanism of target regulation and the relationship between them need to be further explored.…”

Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19

“…It is considered a dietary anticancer prophylactic with antiapoptotic properties [ 5 ]. Biochanin A promotes apoptosis and cell cycle arrest in cancer cells [ 6 7 ]. Reportedly, biochanin A can be used in combination with radiation treatments, because it enhances radiotoxicity in colon tumor cells [ 8 ].…”