Amelioration of Painful Crises in Sickle Cell Disease by Venesections

Iron deficiency decreases hemolysis in sickle cell anemia

“…8,[10][11][12] An RBC count rise above 40% (over non-iron deficiency values), as seen in our patient, may turn out be a useful predictor of the partial iron deficiency state, in which hemolysis decreases without substantial marrow suppression.…”

Adhesion molecules and high‐sensitivity C‐reactive protein levels in patients with sickle cell beta‐thalassaemia

“…Following the therapeutic phlebotomy protocol, they presented a significant amelioration in the number and the severity of crises. Previously, in these patients were reported significant reduction in crises requiring hospitalization ( P = 0·00003); in crises treated on an outpatient basis ( P = 0·02) and in crises treated at home ( P = 0·01) [18]. The study by Bouchaïr [19] and the case report of Markham reached relative conclusions [20].…”

Hemoglobin sickle cell disease complications: a clinical study of 179 cases

“…Phlebotomy efficacy has been previously reported in a few case reports. [37][38][39][40] In our series, so far phlebotomy has been performed in approximately one-third of the patients. Although this study was not designed to assess the efficacy of phlebotomy, our data support the view that this procedure is safe, easy-to-perform and effective in preventing recurrence of acute events.…”