Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet

Manoppo, Jeanette Irene Christiene; Nurkolis, Fahrul; Pramono, Adriyan; Ardiaria, Martha; Murbawani, Etisa Adi; Yusuf, Muhammad; Qhabibi, Faqrizal Ria; Yusuf, Vincentius Mario; Amar, Nasim; Karim, Muhammad Rico Abdul; Subali, Anita Dominique; Natanael, Hans; Rompies, Ronald; Halim, Rifrita Fransisca; Bolang, Alexander S. L.; Joey, Gregory; Novianto, Christian Agung; Permatasari, Happy Kurnia

doi:10.3389/fnut.2022.1010867

Cited by 11 publications

(5 citation statements)

References 52 publications

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“…Caulerpa lentillifera originated in tropical areas around India and the Pacific Ocean, such as Indonesia, but today it can also be found in the Korean Peninsula due to changes in global temperatures. The genus Caulerpa is famous as an edible species that has a high nutritional content, such as minerals, dietary fibers, vitamin A, vitamin C, and several essential unsaturated fatty acids [ 14 , 15 ]. The genus Caulerpa has also been used to treat a wide variety of diseases.…”

Section: Introductionmentioning

confidence: 99%

Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

et al. 2023

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Marine algae have excellent bioresource properties with potential nutritional and bioactive therapeutic benefits, but studies regarding Caulerpa lentillifera are limited. This study aims to explore the metabolites profile and the antioxidant, anticancer, anti-obesity, and in vitro cytotoxicity properties of fractionated ethanolic extract of C. lentillifera using two maceration and soxhlet extraction methods. Dried simplicia of C. lentillifera was mashed and extracted in ethanol solvent, concentrated and evaporated, then sequentially partitioned with equal volumes of ethyl acetate and n-hexane. Six samples were used in this study, consisting of ME (Maceration—Ethanol), MEA (Maceration—Ethyl Acetate), MH (Maceration—n-Hexane), SE (Soxhletation—Ethanol), SEA (Soxhletation—Ethyl Acetate), and SH (Soxhletation—n-Hexane). Non-targeted metabolomic profiling was determined using LC-HRMS, while antioxidant, anti-obesity, and anticancer cytotoxicity were determined using DPPH and ABTS, lipase inhibition, and MTT assay, respectively. This study demonstrates that C. lentillifera has several functional metabolites, antioxidant capacity (EC50 MH is very close to EC50 of Trolox), as well as anti-obesity properties (EC50 MH < EC50 orlistat, an inhibitor of lipid hydrolyzing enzymes), which are useful as precursors for new therapeutic approaches in improving obesity-related diseases. More interestingly, ME, MH, and SE are novel bioresource agents for anticancer drugs, especially for hepatoma, breast, colorectal, and leukemia cancers. Finally, C. lentillifera can be a nutraceutical with great therapeutic benefits.

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Section: Introductionmentioning

confidence: 99%

Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

et al. 2023

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“…This weight-loss potential is in line with other studies involving other species of Caulerpa ( Caulerpa sertularioides and Caulerpa prolifera ), which showed a significant inhibitory effect on adipogenesis of preadipocytes in vitro , with reductions of lipogenic transcription factors such as PPARγ, C/EBPβ, and C/EBPα mRNA [ 30 ]. Applying a similar study model, Caulerpa lentillifera intervention on CFED rats resulted in lower body weight post-treatment (although the results were not significant), as well as a lower FER compared to the other groups [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

et al. 2023

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This study evaluated the effects of an aqueous extract of Caulerpa racemosa (AEC) on cardiometabolic syndrome markers, and the modulation of the gut microbiome in mice administered a cholesterol- and fat-enriched diet (CFED). Four groups of mice received different treatments: normal diet, CFED, and CFED added with AEC extract at 65 and 130 mg/kg body weight (BW). The effective concentration (EC50) values of AEC for 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and lipase inhibition were lower than those of the controls in vitro. In the mice model, the administration of high-dose AEC showed improved lipid and blood glucose profiles and a reduction in endothelial dysfunction markers (PRMT-1 and ADMA). Furthermore, a correlation between specific gut microbiomes and biomarkers associated with cardiometabolic diseases was also observed. In vitro studies highlighted the antioxidant properties of AEC, while in vivo data demonstrated that AEC plays a role in the management of cardiometabolic syndrome via regulation of oxidative stress, inflammation, endothelial function (PRMT-1/DDAH/ADMA pathway), and gut microbiota.

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“…Based on the existence of photosynthetic pigments, green algae are members of the Chlorophyta phylum of the Plantae kingdom (15). As stated above, seaweed has several health-benefiting potentials (16)(17)(18). Numerous sulfated and carboxylated polysaccharides, including alginate, ulvan, and fucoidan, as well as carotenoids, phenolic compounds, tocopherols, and peptides, are among the many bioactive substances found in seaweed (19).…”

Section: Green Seaweeds and Anticancer Propertiesmentioning

confidence: 99%

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

et al. 2023

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Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet

Abstract: Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet.

Cited by 11 publications

References 52 publications

Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

Dietary Supplementation of Caulerpa racemosa Ameliorates Cardiometabolic Syndrome via Regulation of PRMT-1/DDAH/ADMA Pathway and Gut Microbiome in Mice

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

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