Amelioration of neurobehavioral and cognitive abilities of F1 progeny following dietary supplementation with Spirulina to protein malnourished mothers

Sinha, Shrstha; Patro, Nisha; Patro, Nisha

doi:10.1016/j.bbi.2019.08.181

Cited by 25 publications

(19 citation statements)

References 85 publications

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“…These cellular changes due to protein malnourishment also led to behavioral deficits in terms of hyperactivity and anti-anxiety like symptoms reflecting the direct consequence of protein restriction during crucial period of life. Such behavioral deficits have been variously reported following maternal protein malnourishment ( Chertoff, 2015 ; Naik et al, 2015 ; Sinha et al, 2020 ).…”

Section: Discussionmentioning

confidence: 85%

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Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology

Sarkar

Patro

2022

Biology Open

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Protein malnourishment and immune stress are potent perinatal stressors, encountered by children born under poor socioeconomic condition. Thus, it is necessary to investigate how such stressors synergistically contribute towards developing neurological disorders in affected individuals. Pups from Wistar females, maintained on normal (high protein:HP:20%) and low protein (LP:8%) diets were used. Single and combined exposures of Poly I:C (viral mimetic:5mg/kg body wt.) and LPS (bacterial endotoxin:0.3 mg/kg body wt.) were injected to both HP and LP pups at postnatal day (PND) 3 and 9 respectively, creating 8 groups: HP (control), HP+Poly I:C, HP+LPS, HP+Poly I:C+LPS, LP, LP+Poly I:C, LP+LPS, LP+Poly I:C+LPS (multi-hit). The effects of stressors on hippocampal cytoarchitecture and behavioral abilities were studied at PND 180. LP animals were found vulnerable to immune stressors then HP animals and symptoms like neuronal damage, spine loss, downregulation of Egr 1 and Arc proteins, gliogenesis and behavioral deficits were maximum in multi-hit group. Thus, from these findings it is outlined that cellular and behavioral changes that occur following multi-hit exposure may predispose individuals to develop Schizophrenia like pathologies during adulthood.

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Section: Discussionmentioning

confidence: 85%

“…shown deterioration of behavior as detected by EPM and OFT experiments (Meyer, 2014;Naik et al, 2015;Singh et al, 2017;Baghel et al, 2018;Sinha et al, 2019).…”

Section: Biology Open • Accepted Manuscriptmentioning

confidence: 99%

Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology

Sarkar

Patro

2022

Biology Open

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“…Nutrition is one of the most important environmental factors that influence brain development [ 58 , 59 ]; several studies showed that maternal malnutrition affects brain development and probably represents a leading factor in the pathogenesis of neurological and psychiatric disorders in an offspring [ 60 , 61 , 62 ]. A more recent article demonstrated that Spirulina supplementation to protein-deprived mothers intensifies reflex maturation, reduces mortality, and ameliorates behavioral and cognitive problems in the offspring; moreover, it attenuated protein malnutrition-induced microgliosis, which may provide for the restoration of neurocognitive outcomes [ 63 ]. In another study, Sinha et al observed that maternal dietary supplementation with Spirulina during pregnancy, and lactation to protein-malnourished (PMN) rats reduced astrocytic and microglial activation in F1 progeny.…”

Section: Role Of Spirulina In the Brainmentioning

confidence: 99%

Beneficial Effects of Spirulina Consumption on Brain Health

et al. 2022

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Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels of functional compounds, such as phycocyanins, phenols and polysaccharides, with anti-inflammatory, antioxidant, immunomodulating properties both in vivo and in vitro. Several scientific publications have suggested its positive effects in various pathologies such as cardiovascular diseases, hypercholesterolemia, hyperglycemia, obesity, hypertension, tumors and inflammatory diseases. Lately, different studies have demonstrated the neuroprotective role of Spirulina on the development of the neural system, senility and a number of pathological conditions, including neurological and neurodegenerative diseases. This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson’s disease, Alzheimer’s disease and Multiple Sclerosis; due to these properties, Spirulina could be considered a potential natural drug.

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“…In the physical dimension, studies have shown that improved uterine perfusion prevents various complications such as preeclampsia [ 3 , 4 ], premature birth [ 5 , 6 ], intrauterine growth restriction [ 7 , 8 ], and small fetus for gestational age [ 9 , 10 ]. The measures that improve mothers’ health during pregnancy can ameliorate uterine perfusion and reduce both maternal and fetal complications [ 11 , 12 ]. Yoga is considered one of the oldest alternative medicine interventions [ [13] , [14] , [15] ].…”

Section: Introductionmentioning

confidence: 99%

The effect of yoga on uterine artery Doppler indices, maternal and fetal complications in pregnant women: A quasi-experimental study

Bouya¹,

Keikhaie²,

Hosseini³

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background Today, the effect of yoga has been examined on various physical and psychological dimensions of pregnant women. However, there are still sparse studies on the effect of yoga on the uterine artery indices as well as maternal and fetal complications. Objective The aim was to determine the effect of yoga on uterine artery Doppler indices, maternal and fetal Complications. Materials and methods This quasi-experiential study was conducted, on 100 pregnant women. The participants were assigned to yoga and control groups. In the yoga group, the participants exercised yoga for 1 h. On the other hand, the control group received routine care. Results The results showed that in the yoga group, the functional indices of the uterine artery (S/D, PI, RI, and DN) improved more significantly compared to the control (p = 0.01). The results also showed that in the yoga group, maternal complications (diabetes and preeclampsia), as well as fetal complications (SAG, IUGR), were significantly lower compared to the control (p = 0.01). Conclusion This study revealed the positive effects of yoga on improving fetal development indices and reducing maternal and fetal complications following pregnancy. It can be used as a Complementary therapy alongside other treatments for mothers.

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Amelioration of neurobehavioral and cognitive abilities of F1 progeny following dietary supplementation with Spirulina to protein malnourished mothers

Cited by 25 publications

References 85 publications

Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology

Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology

Beneficial Effects of Spirulina Consumption on Brain Health

The effect of yoga on uterine artery Doppler indices, maternal and fetal complications in pregnant women: A quasi-experimental study

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