Amelioration of Liver Ailments by Saffron (Crocus sativus) and Its Secondary Metabolites

Sumaiya, Sajida; Naved, Tanveer; Sharma, Archana; Sarwat, Maryam

doi:10.1016/b978-0-12-818462-2.00001-2

Cited by 5 publications

(5 citation statements)

References 58 publications

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“…It also confirms the hepatoprotective property of silymarin, a synthetic drug. Sumaiya et al 36 reported reduced occurrence of lesions in the liver, on treatment with ethanol and aqueous extracts of saffron. The hepatoprotective capacity of ethanol extract of C. dolichopentalum can be attributed to attenuation of radical formation from CCl4 by inhibition of activities of cytochrome P450 and enhanced radical scavenging by the plants bioactive compounds.…”

Section: Resultsmentioning

confidence: 99%

Investigating the Effect of Flavonoid, Saponin, Alkaloids and Tannins Extracted from Combretum dolichopentalum Diels in CCl4 –Induced Hepatotoxicity

2022

TJNPR

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Plant based drugs used in traditional medicine practice have become the model of current research because they are affordable, effective, and with minimal side effects.Research shows that C. dolichopentalum possess a very high content of minerals such as sodium, potassium, and vitamins such as vitamins A, thiamine and niacin. It also contains essential amino acids like leucine and arginine and acidic amino acids. 4,6 Combretum dolichopentalum leaves contain in varying concentration, flavonoids such as epicatechin, anthocyanin, rutin, and kaempferol and other bioactive compounds. 7,8,9 Furthermore, C. dolichopentalum is bactericidal as expressed against Salmonella typhi and Escherichia coli, 10 Staphylococcus aureaus, P. aeruginosa and C. albicans. 11 The use of plant extracts have been reported to normalize adverse biochemical changes in vivo. 2,12,13 However, there are scarce materials on specific phytochemical fractions involved in ameliorating adverse biochemical and physiological changes. Therefore, this study investigated the effect of flavonoids, alkaloids, saponins, and tannins extracted from Combretum dolichopentalum on CCl4-induced hepatotoxicity. The study desired to elucidate the effect of the crude extract vis-a vis the specific phytochemical fractions of C. dolichopentalum leaf responsible for the hepatoprotective potentials. Materials and Methods Collection and authentication of plant materialFresh plants of C.

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Section: Resultsmentioning

confidence: 99%

Investigating the Effect of Flavonoid, Saponin, Alkaloids and Tannins Extracted from Combretum dolichopentalum Diels in CCl4 –Induced Hepatotoxicity

2022

TJNPR

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“…The chemoprevention of hepatocellular carcinoma (HCC), the second most frequent cause of cancer-related deaths amongst males, is a promising approach against its development and metastasis (Bray et al, 2018). Natural herbs and plants, such as saffron, have received immense attention for their role as an antiproliferative and proapoptotic agent in different hepatocellular cancer cell lines (Sumaiya et al, 2020). Saffron treatment significantly restricted cell growth and induced cell apoptosis, and the G0/G1 phase cell cycle arrest QGY-7703 cell lines.…”

Section: Activities Against Cancersmentioning

confidence: 99%

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

Khan¹,

Muhamad²,

Taha³

et al. 2021

IFRJ

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Crocus sativus L., a medicinally important species of the Iridaceae family which produces the herb saffron, plays an effective role in combating various pathogenic disorders including cancers and cardiovascular diseases. Apart from its conventional colorant and aroma-inducing attributes, various phytochemical compounds associated with saffron are now being intensively studied. More than 300 phytochemical compounds, derived from saffron stigmas alone, belong to various classes of secondary metabolites such as carotenoids, terpenoids, flavonoids, and anthocyanins; and they have immense therapeutic applications. Furthermore, pharmacogenomic studies of saffron extracts have revealed promising biocompatible and anticancer potentials against various drug-resistant cell lines which reduce cellular division and proliferation of malignant cells. Keeping in view with the numerous pharmacological properties associated with saffron, the present review explicitly discusses the role of its elemental contents in the prevention and treatment of various cancers and cardiovascular ailments.

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“…Saffron is rich in carotenoids (Crocin), glycoside (Picrocrocin), and a volatile fatty substance (Safranal) ( 8 ). Recently, extensive studies have established this substance as a strong antioxidant ( 9 - 11 ) that protects tissues ( 12 - 14 ). Crocin extract was able to significantly ameliorate hyperlipidemia by inhibiting pancreatic lipase.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Saffron Intervention on NAFLD Status and Related Gene Expression in a Rat Model

Alipour

Aryaeian

Hajiluian

et al. 2023

MJIRI

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Amelioration of Liver Ailments by Saffron (Crocus sativus) and Its Secondary Metabolites

Cited by 5 publications

References 58 publications

Investigating the Effect of Flavonoid, Saponin, Alkaloids and Tannins Extracted from Combretum dolichopentalum Diels in CCl4 –Induced Hepatotoxicity

Investigating the Effect of Flavonoid, Saponin, Alkaloids and Tannins Extracted from Combretum dolichopentalum Diels in CCl4 –Induced Hepatotoxicity

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

The Effect of the Saffron Intervention on NAFLD Status and Related Gene Expression in a Rat Model

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