“…Mulberry leaf tea has been recorded for diabetes treatment in “ Compendium of Materia Medica ,” which was booked by the pharmacist Shi‐Zhen Li of the Ming Dynasty in ancient China. Recently, our group has demonstrated that mulberry leaf water or ethanol extracts can improve lipid metabolism disorder, glucose homeostasis, inflammation, oxidative stress, insulin secretion, and gut microbiota imbalance in high‐fat diet and/or streptozotocin (STZ)‐induced obese or type 2 diabetic mice (Du, Li, Lu, Zhang, Zhao, et al, 2022; Du, Li, Lu, Zhang, Zheng, 2002; Du, Li, Lu, Zhang, Zhong, et al, 2022; Ji et al, 2021). However, studies about the impact of mulberry leaf on BCAAs metabolism and relative gut microbiota in T2DM are still limited.…”