Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

Nojiri, Hiroshi; Ishida, Koichi; Yao, Xueqiu; Wei, Liu; Imokawa, Genji

doi:10.1007/s00403-018-1833-9

Cited by 17 publications

(25 citation statements)

References 42 publications

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“…Fan Linna et al found that sebum secretion in the sensitive skin (SS) group was lower than that in the nonsensitive skin (NS) group, suggesting that the development of SS might be associated with sebum secretion and its specific components . Nojiri H et al found that stimulating the barrier function and improving the ceramide profile could improve the lactic acid sensitivity in sensitive skin . We found in oily skin groups the correlation between skin sensitivity and eating spicy food as well as sleeping time in the past week was statistically significant ( P < .01), while in neutral skin groups there were significant correlations between the sleeping time and sleeping quality with skin sensitivity ( P < .01).…”

Section: Discussionmentioning

confidence: 60%

Skin sensitivity evaluation: What could impact the assessment results?

Chen

Sulian

et al. 2019

J of Cosmetic Dermatology

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Background: For the evaluation results of skin sensitivity, such as clinical parameters, stinging test records and biophysical assessments dates might be impacted by many factors, the influence factors need to be further explored, and the skin sensitivity evaluation process and methodology needed distinction and normalization. In this study, we investigated the changes of sensitive skin indexes and lactic acid stinging test results in different seasons, facial regions, skin photo-type, and living habits.Methods: Twenty-four healthy subjects had completed this study. Lactic acid stinging test was performed in different seasons. Transepidermal water loss (TEWL), skin hydration, sebum secretion, and pH were measured in an environment-controlled room. Correlations between stinging responses, skin biophysical parameters, and sensitive skin inducements in different seasons were statistically analyzed.Results: Skin TEWL, hydration, sebum secretion, and pH values on different facial parts were various. Two-way correlation analysis between the results of lactic acid stinging test in different seasons and the sensitivity factors showed differences between summer, autumn, and winter. The mean scores of lactic acid stinging test increased in autumn. Linear regression analysis of skin sensitivity factors in type III and type IV photobiology skin found that the frequency of sleeping time and eating spicy food in the past of week could infect the sensitive skin evaluation dates statistically (P < .05).Discussion/Conclusions: Skin sensitivity assessment results were impacted by seasonal transformation, living habits and customs, and facial regions. These indicted that we should consider above interfering factors when evaluated the skin sensitivity for getting more precise dates. K E Y W O R D Sassessment, lactic acid stinging test, sensitive skin, skin index

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Section: Discussionmentioning

confidence: 60%

Skin sensitivity evaluation: What could impact the assessment results?

Chen

Sulian

et al. 2019

J of Cosmetic Dermatology

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“…Sensitive skin is an abnormal subclinical sensory response that includes tingling, tightness, burning or prickling, and possibly pain or itching that may be caused by medications, cosmetics, and toiletries, but without obvious symptoms [20]. In fact, people of different ages and genders have different levels of exposure to such irritants in different working or living environments, which may affect the development of sensitive skin symptoms [21].…”

Section: Discussionmentioning

confidence: 99%

Will Repeated Low‐Energy 1064‐nm Q‐Switched Nd:YAG Laser Treatment Sessions Affect Facial Skin Sensitivity? Results of a 12‐Month, Prospective, Randomized Split‐Face Study

et al. 2021

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Background and Objective To compare changes in skin sensitivity before and after treatment with a 1064‐nm Q‐switched Nd:YAG laser in healthy individuals, and to provide a reference for clinicians to use this laser reasonably. Study Design/Materials and Methods Nineteen healthy female volunteers underwent 10 random unilateral 1064‐nm Q‐switched Nd:YAG laser treatments. The skin transepidermal water loss rate (TEWL), skin glossiness, epidermal and dermal thickness and density, current perception threshold (CPT) value, facial blood perfusion were determined before and after treatment at different time points. Moreover, the changes in skin barrier function, blood vessels, and sensory nerve reaction in the treated and untreated sides of the face were recorded before and after treatment. Results Seventeen volunteers completed the 12‐month follow‐up study after 1064‐nm Q‐switched Nd:YAG laser treatment. At D3, M3, and M6, skin TEWL was decreased on the treated side of the face. Skin glossiness was significantly improved in the early post‐treatment period (D1–D7) and M3, M6, and M12 compared with the untreated side of the face. There was no significant change in dermal and epidermal thickness or density at all time points before and after treatment. There were no significant differences in sensory nerve CPT values and local blood flow volume or velocity between the treated side of the face and the untreated side before and after treatment. Conclusion Multiple low‐energy 1064‐nm Q‐switched Nd:YAG laser treatments will not affect the barrier function of facial skin, skin nerve sensitivity, or local microcirculation of healthy skin over the long term. Therefore, 1064‐nm Q‐switched Nd:YAG laser treatment is safe, and does not alter skin sensitivity. Lasers Surg. Med. © 2021 Wiley Periodicals LLC

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“…“Sensitive skin (SS)” is defined by a special interest group, the International Forum for the Study of Itch1, 1 as skin that develops an uncomfortable sensation in reaction to stimuli that skin should not normally react to various pathophysiological mechanisms are thought to be implicated in sensitive skin development 2 . Neuropathy‐like discomfort sensations, such as burning, stinging, pain, and itching, are characteristic features of sensitive skin; therefore, it is postulated that a neurosensory disorder accompanied by epidermal barrier dysfunction plays a significant role in the pathogenesis of SS 3,4 …”

Section: Introductionmentioning

confidence: 99%

Association between biophysical properties and anxiety in patients with sensitive skin

Manav

Karaali

Erdem

et al. 2022

Skin Research and Technology

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Background: Sensitive skin (SS) is a syndrome in which neurosensory disorders accompany epidermal barrier dysfunction. However, it is not yet clear how high anxiety levels affect the biophysical parameters of the skin in patients with SS. Objectives:We aimed to investigate the relationship between anxiety levels and facial neurosensitivity, the erythema index, sebum content, and sensitive skin scale scores in individuals with sensitive skin. Methods:The study was carried out on 35 individuals with SS and 40 without SS over three months. In the study, a questionnaire to detect the presence of sensitive skin, the sensitive skin scale for sensitive skin severity, the lactic acid sting test (LAST) to show facial neurosensitivity, a Mexameter for erythema index measurement, and a Sebumeter for sebum content measurement were used. In addition, the anxiety levels of the patient and control groups were measured using the hospital anxiety and depression scale (HADS).Results: While the HADS-Anxiety scores were found to be significantly higher in patients with sensitive skin, there was no significant difference in the HADS-Depression scores. Moreover, a strong positive correlation was found between the HADS-Anxiety scores and the erythema index in patients with sensitive skin. Conclusions:Sensitive skin is a disorder that can sometimes occur without any dermatological examination findings. In particular, the sensations of the patients, along with their anxiety levels, are essential parameters that should be evaluated in the approach to patients with sensitive skin.

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Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

Cited by 17 publications

References 42 publications

Skin sensitivity evaluation: What could impact the assessment results?

Skin sensitivity evaluation: What could impact the assessment results?

Will Repeated Low‐Energy 1064‐nm Q‐Switched Nd:YAG Laser Treatment Sessions Affect Facial Skin Sensitivity? Results of a 12‐Month, Prospective, Randomized Split‐Face Study

Association between biophysical properties and anxiety in patients with sensitive skin

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