Amelioration of Insulin, Leptin and Adiponectin Levels in Experimental Metabolic Syndrome Model by Some Drugs

Rasheed, Nadia; Abdelkarem, Hala M.; Laila, F M; Azza, M M; Nawal, M Al Rasheed; Bassiouni, Yieldez; Ali, H.M.; Abeer, H G

doi:10.4172/pharmaceutical-sciences.1000173

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…O n l i n e F i r s t O n l i n e F i r s t significantly reduced the increase in leptin levels, brought them to near-normal levels, and improved adiponectin levels. Our results are in agreement with previous research (Al-Rasheed et al, 2017;Stoica et al, 2021). Obesity is characterized by a wide range of circulating adipokine levels due to the aberrant accumulation and dysfunction of adipose tissues.…”

Section: Discussionsupporting

confidence: 94%

Goldenberry (Physalis peruviana) alleviates hepatic oxidative stress and metabolic syndrome in obese rats

Abdelmottaleb¹,

Ibrahim²,

Mohamed³

et al. 2022

j app pharm sci

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The objective of this study was to investigate the effect of goldenberry (GB) (Physalis peruviana) extract supplementation on fat accumulation, hepatic oxidative damage, hepatic fat deposition, inflammation, and hepatic scarring, as well as metabolic syndrome in obese rats. Obesity was induced by feeding rats a high-fat diet for 12 weeks. Female Wister rats were divided into four groups (eight each): control group, obese group, obese + a lowdose GB (200 mg/kg), and obese + a high-dose GB (400 mg/kg). Body mass index (BMI), adipose tissue hormones, lipid profile, liver enzymes, hepatic oxidative stress parameters, and hepatic histopathological changes were assessed. Treating obese rats with GB supplementation reduced their increased body weight, BMI, leptin level, cholesterol, triglycerides, glucose, and insulin resistance index (homeostatic model assessment for insulin resistance). Moreover, the GB regime significantly improved the antioxidant parameters in the liver. In addition, it has shown a significant antiobesity impact by lessening body weight, oxidative damage, BMI, lipids, and insulin insensitivity. Eventually, administration of GB extracts reduced markers of inflammation [tumor necrosis factor-alpha, interleukin (IL)-2, IL-6, and C-reactive protein], fat deposition, steatosis, and fibrosis in the liver of the obese rats. Moreover, GB intake can be used in coupling with a healthy diet to assist obese rats suffering from metabolic syndrome.

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Section: Discussionsupporting

confidence: 94%

Goldenberry (Physalis peruviana) alleviates hepatic oxidative stress and metabolic syndrome in obese rats

Abdelmottaleb¹,

Ibrahim²,

Mohamed³

et al. 2022

j app pharm sci

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“…The results of this investigation showed that when compared to the controls, rats overfed with fructose resulted in elevated plasma glucose and insulin levels, increased insulin/glucose ratio, and decreased liver and muscle glycogen stores, confirming the report of AL-Rasheed et al (2016). Such changes may be associated with glucose tolerance and insulin resistance when there is an excess fructose supply.…”

Section: Discussionsupporting

confidence: 86%

Effects of Pumpkin (Cucurbita pepo L.) Seed Protein on Blood Pressure, Plasma Lipids, Leptin, Adiponectin, and Oxidative Stress in Rats with Fructose-Induced Metabolic Syndrome

Chenni

Cherif

Chenni

et al. 2022

Prev. Nutr. Food Sci.

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This study evaluates the potential effects of pumpkin seeds protein on blood pressure (BP), plasma adiponectin, leptin levels, and oxidative stress in rats with fructose-induced metabolic syndrome. Twenty four male Wistar albino rats were divided into four groups and fed a 20% casein diet, 20% casein diet supplemented with pumpkin protein, 20% casein diet with 64% D-fructose, or 20% casein diet with pumpkin protein and 64% D-fructose for 8 weeks. Continuous fructose feeding induced an increase in plasma insulin/glucose ratio, BP, insulin and glucose, aspartate aminotransferase, alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, and uric acid levels, and a decrease in the liver and muscle glycogen stores. In addition, elevated levels of total cholesterol (TC), triglycerides (TG), and leptin and lowered adiponectin levels were observed in rats fed a fructose-enriched diet. These groups also exhibited lower plasma levels of ascorbic acid and glutathione, higher thiobarbituric acid-reactive substances, hydroperoxide, carbonyl, and nitric oxide in both the liver and kidneys than rats fed the control diet. Interestingly, pumpkin seed protein treatment significantly counteracted alterations induced by fructose improving glucose, insulin, BP, TG, TC, ALT, and ALP levels, increasing liver and muscle glycogen stores, adiponectin level, and adiponectin/leptin ratio, and reducing plasma leptin levels. In addition, rats fed pumpkin protein with a high-fructose diet improved oxidative stress in the liver and kidneys. In conclusion, proteins from Cucurbita pepo L. seeds effectively improve metabolic parameters and protect against oxidative stress induced by a high-fructose diet.

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Alagebrium Mitigates Metabolic Insults in High Carbohydrate and High Fat Diet Fed Wistar Rats

et al. 2020

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Background: Metabolic syndrome (MS) is characterized by sustained hyperglycemia that triggers advanced glycation end products (AGEs) generation. Alagebrium (ALA) is an advanced glycation end products (AGEs) cross-links breaker.Methods: 32 Wistar rats were divided into normal control (NC) group (8 rats) and MS groups (24 rats) received a high carbohydrate high fat diet (HCFD) for 10 weeks. Rats with established MS were equally divided into 3 subgroups remained on HCFD for further 6 weeks: MS control (MSC), ALA treated received 10 mg/kg/day ALA orally and metformin treated (MF) (a reference drug) received 50 mg/kg/day MF orally. The studied parameters were systolic blood pressure (SBP), body and liver weights (BW, LW), LW/BW% ratio, fasting blood glucose (FBG), serum insulin, lipid profile, liver enzymes, serum AGEs, hepatic Interleukin-17 (IL-17), adipokines, pAkt/Akt ratio, and liver histopathology. Results: HCFD elevated SBP, BW, LW and LW/BW% ratio, FBG, serum insulin, and AGEs. It also deteriorated lipid profile and liver enzymes, induced inflammation, insulin resistance and histopathological derangements. ALA ameliorated the elevated SBP, FBG, lipid profile, liver enzymes, mitigated insulin resistance, hepatic IL-17, serum AGEs, modulated adipokines levels and improved liver histopathology. However, MF had better effects than ALA in all studied parameters except AGEs. Conclusion: ALA is protective against dietary-induced MS via ameliorating the inflammatory process and serum AGEs that implicated in MS pathogenesis, which makes it a promising new tool in MS treatment.

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Amelioration of Insulin, Leptin and Adiponectin Levels in Experimental Metabolic Syndrome Model by Some Drugs

Cited by 4 publications

References 38 publications

Goldenberry (Physalis peruviana) alleviates hepatic oxidative stress and metabolic syndrome in obese rats

Goldenberry (Physalis peruviana) alleviates hepatic oxidative stress and metabolic syndrome in obese rats

Effects of Pumpkin (Cucurbita pepo L.) Seed Protein on Blood Pressure, Plasma Lipids, Leptin, Adiponectin, and Oxidative Stress in Rats with Fructose-Induced Metabolic Syndrome

Alagebrium Mitigates Metabolic Insults in High Carbohydrate and High Fat Diet Fed Wistar Rats

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