Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid

Lefler, Scott R.; Peter, Shawn D. St.; Rodríguez-Dávalos, Manuel I.; Perumean, J. C.; Spence, N. A.; Moss, Adyr; Mulligan, David C.

doi:10.1016/s0041-1345(02)03616-3

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…IPA is well known for its hydroxyl radical and lipid peroxide scavenging activity. Lefler et al investigated the capacity of IPA to ameliorate liver damage following an ischemic event in rats [ 86 ]. They found that the pretreatment with IPA significantly reduced serum alanine aminotransferase, and aspartate aminotransferase during the reperfusion [ 86 ].…”

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…Lefler et al investigated the capacity of IPA to ameliorate liver damage following an ischemic event in rats [ 86 ]. They found that the pretreatment with IPA significantly reduced serum alanine aminotransferase, and aspartate aminotransferase during the reperfusion [ 86 ]. The hepatoprotective effects of IPA have also been reported in rodent studies focused on NAFLD and NASH and in vitro studies related to hepatocyte functioning [ 87 , 88 ].…”

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

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Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

et al. 2022

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An intricate relationship between gut microbiota, diet, and the human body has recently been extensively investigated. Gut microbiota and gut-derived metabolites, especially, tryptophan derivatives, modulate metabolic and immune functions in health and disease. One of the tryptophan derivatives, indolepropionic acid (IPA), is increasingly being studied as a marker for the onset and development of metabolic disorders, including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). The IPA levels heavily depend on the diet, particularly dietary fiber, and show huge variations among individuals. We suggest that these variations could partially be explained using genetic variants known to be associated with specific diseases such as T2D. In this narrative review, we elaborate on the beneficial effects of IPA in the mitigation of T2D and NAFLD, and further study the putative interactions between IPA and well-known genetic variants (TCF7L2, FTO, and PPARG), known to be associated with the risk of T2D. We have investigated the long-term preventive value of IPA in the development of T2D in the Finnish prediabetic population and the correlation of IPA with phytosterols in obese individuals from an ongoing Kuopio obesity surgery study. The diversity in IPA-linked mechanisms affecting glucose metabolism and liver fibrosis makes it a unique small metabolite and a promising candidate for the reversal or management of metabolic disorders, mainly T2D and NAFLD.

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Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

et al. 2022

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Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets

Ming,

Xu,

Jiang

et al. 2024

Animal Nutrition

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Indole-3-Propionic Acid Enhances Growth Performance and Reduces Diarrhea Via Modulating Redox Status and Intestinal Inflammation in Weaned Piglets

Ming,

Xu,

Jiang

et al. 2024

Preprint

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Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid

Cited by 3 publications

References 6 publications

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets

Indole-3-Propionic Acid Enhances Growth Performance and Reduces Diarrhea Via Modulating Redox Status and Intestinal Inflammation in Weaned Piglets

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